Table of Contents: December 2007


1,000 year old yew

Image Credit: Photograph by C. Patrick Doncaster, University of Southampton, UK
Issue Image

This healthy yew has stood for at least 1,000 years in St. Nicholas churchyard near Brockenhurst, UK. New analyses of life-history evolution show how any such sessile organism can postpone indefinitely the onset of senescent aging. Simulations further demonstrate for the first time the possibility of evolved immortality (see Seymour and Doncaster, e256).

Message from ISCB


Computational Biology in Argentina

Sebastian Bassi, Virginia González, Gustavo Parisi

Research Articles

Social Interactions in Myxobacterial Swarming

Yilin Wu, Yi Jiang, Dale Kaiser, Mark Alber

Analysis of Sequence Conservation at Nucleotide Resolution

Saurabh Asthana, Mikhail Roytberg, John Stamatoyannopoulos, Shamil Sunyaev

Determination of the Processes Driving the Acquisition of Immunity to Malaria Using a Mathematical Transmission Model

João A. N Filipe, Eleanor M Riley, Christopher J Drakeley, Colin J Sutherland, Azra C Ghani

Operating Regimes of Signaling Cycles: Statics, Dynamics, and Noise Filtering

Carlos Gomez-Uribe, George C Verghese, Leonid A Mirny

Comparative Genomics Search for Losses of Long-Established Genes on the Human Lineage

Jingchun Zhu, J. Zachary Sanborn, Mark Diekhans, Craig B Lowe, Tom H Pringle, David Haussler

Animal Cell Differentiation Patterns Suppress Somatic Evolution

John W Pepper, Kathleen Sprouffske, Carlo C Maley

Stereochemical Criteria for Prediction of the Effects of Proline Mutations on Protein Stability

Kanika Bajaj, M. S Madhusudhan, Bharat V Adkar, Purbani Chakrabarti, C Ramakrishnan, Andrej Sali, Raghavan Varadarajan