Table of Contents | May 2009

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DNA damage induces phase advances in the circadian clock.

DNA damage in mammalian cells leads to activation of the cell cycle regulator Chk2, which triggers downstream degradations of a core clock component, PER (i.e., PER1 in mice). This, in turn, creates unique phase shifts (mostly advances) in the circadian clock. Computational analyses from Hong et al. (doi:10.1371/journal.pcbi.1000384) recapitulate a phase advance (dashed curve) when DNA damage occurs around the peak of PER abundance, but minimum phase shifts around the trough (dots). The model proposes a molecular mechanism behind this phenomenon: differential degradation of PER in the presence of an essential positive feedback loop in the circadian system.

Image Credit: Judit Zámborszky (CoSBi, Microsoft Research-University of Trento Centre for Computational and Systems Biology, Italy).

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Table of Contents | May 2009

About This Image

Messages from ISCB

Getting Started in Computational Mass Spectrometry–Based Proteomics

BioLINK Special Interest Group Session on the Future of Scientific Publishing

Perspective

Hypergraphs and Cellular Networks

Review

What Is Stochastic Resonance? Definitions, Misconceptions, Debates, and Its Relevance to Biology

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A Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its Family

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