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Table of Contents: July 2012

COVER

Visualization of an ant trail pattern.

Image Credit: Andrea Perna, Department of Mathematics, Uppsala University.
Issue Image

The pattern in the figure was produced by a colony of Argentine ants after one hour of exploration of an empty arena. Many ant species form similar dendritic patterns around their nests, but the patterns are invisible to the human eye as they are composed of extremely low concentrations of chemicals (pheromones). In this image, the structure of the trails and the intensity of pheromone marking are made visible from the positions of the ants. See Perna et al., doi:10.1371/journal.pcbi.1002592.

Education

Perspectives

Bioinformatics Meets User-Centred Design: A Perspective

Katrina Pavelin, Jennifer A. Cham, Paula de Matos, Cath Brooksbank, Graham Cameron, Christoph Steinbeck

Review

Digital Epidemiology

Marcel Salathé, Linus Bengtsson, Todd J. Bodnar, Devon D. Brewer, John S. Brownstein, Caroline Buckee, Ellsworth M. Campbell, Ciro Cattuto, Shashank Khandelwal, Patricia L. Mabry, Alessandro Vespignani

Research Articles

Shaping the Dynamics of a Bidirectional Neural Interface

Alessandro Vato, Marianna Semprini, Emma Maggiolini, Francois D. Szymanski, Luciano Fadiga, Stefano Panzeri, Ferdinando A. Mussa-Ivaldi

Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity

Miles Miller, Marc Hafner, Eduardo Sontag, Noah Davidsohn, Sairam Subramanian, Priscilla E. M. Purnick, Douglas Lauffenburger, Ron Weiss

Individual Rules for Trail Pattern Formation in Argentine Ants (Linepithema humile)

Andrea Perna, Boris Granovskiy, Simon Garnier, Stamatios C. Nicolis, Marjorie Labédan, Guy Theraulaz, Vincent Fourcassié, David J. T. Sumpter

Suppressed Expression of T-Box Transcription Factors Is Involved in Senescence in Chronic Obstructive Pulmonary Disease

George K. Acquaah-Mensah, Deepti Malhotra, Madhulika Vulimiri, Jason E. McDermott, Shyam Biswal

Location-Dependent Excitatory Synaptic Interactions in Pyramidal Neuron Dendrites

Bardia F. Behabadi, Alon Polsky, Monika Jadi, Jackie Schiller, Bartlett W. Mel

Excitatory Local Interneurons Enhance Tuning of Sensory Information

Collins Assisi, Mark Stopfer, Maxim Bazhenov

Coding Conspecific Identity and Motion in the Electric Sense

Na Yu, Ginette Hupé, Charles Garfinkle, John E. Lewis, André Longtin

Adaptive Temperature Compensation in Circadian Oscillations

Paul François, Nicolas Despierre, Eric D. Siggia

Efficient Reverse-Engineering of a Developmental Gene Regulatory Network

Anton Crombach, Karl R. Wotton, Damjan Cicin-Sain, Maksat Ashyraliyev, Johannes Jaeger

Efficiency and Power as a Function of Sequence Coverage, SNP Array Density, and Imputation

Jason Flannick, Joshua M. Korn, Pierre Fontanillas, George B. Grant, Eric Banks, Mark A. Depristo, David Altshuler

Microbial Co-occurrence Relationships in the Human Microbiome

Karoline Faust, J. Fah Sathirapongsasuti, Jacques Izard, Nicola Segata, Dirk Gevers, Jeroen Raes, Curtis Huttenhower

Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis

Jae-Seong Yang, Sang Woo Seo, Sungho Jang, Gyoo Yeol Jung, Sanguk Kim

Prediction of Microbial Growth Rate versus Biomass Yield by a Metabolic Network with Kinetic Parameters

Roi Adadi, Benjamin Volkmer, Ron Milo, Matthias Heinemann, Tomer Shlomi

Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia

Peilin Jia, Lily Wang, Ayman H. Fanous, Carlos N. Pato, Todd L. Edwards, Zhongming Zhao , The International Schizophrenia Consortium

Automated Tracking of Whiskers in Videos of Head Fixed Rodents

Nathan G. Clack, Daniel H. O'Connor, Daniel Huber, Leopoldo Petreanu, Andrew Hires, Simon Peron, Karel Svoboda, Eugene W. Myers