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Open Access
Peer-reviewed
Research Article
Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays
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Rameen Beroukhim ,
Contributed equally to this work with: Rameen Beroukhim, Ming Lin
Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
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Ming Lin ,
Contributed equally to this work with: Rameen Beroukhim, Ming Lin
Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
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Yuhyun Park,
Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
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Ke Hao,
Affiliation Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
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Xiaojun Zhao,
Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
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Levi A Garraway,
Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
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Edward A Fox,
Affiliation Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
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Ephraim P Hochberg,
Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America , Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
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Ingo K Mellinghoff,
Affiliation Departments of Medicine and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
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Matthias D Hofer,
Affiliations Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
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Aurelien Descazeaud,
Affiliations Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
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Mark A Rubin,
Affiliations Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
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Matthew Meyerson,
Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America , Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Wing Hung Wong,
Affiliation Department of Statistics, Stanford University, Stanford, California, United States of America
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William R Sellers ,
*To whom correspondence should be addressed. E-mail: william.sellers@novartis.com (WRS); cli@hsph.harvard.edu (CL)
¤ Current address: Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America
Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America , Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Cheng Li
*To whom correspondence should be addressed. E-mail: william.sellers@novartis.com (WRS); cli@hsph.harvard.edu (CL)
Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
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Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays
- Rameen Beroukhim,
- Ming Lin,
- Yuhyun Park,
- Ke Hao,
- Xiaojun Zhao,
- Levi A Garraway,
- Edward A Fox,
- Ephraim P Hochberg,
- Ingo K Mellinghoff,
- Matthias D Hofer
- Published: May 12, 2006
- https://doi.org/10.1371/journal.pcbi.0020041