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Research Article

Synonymous Substitution Rates Predict HIV Disease Progression as a Result of Underlying Replication Dynamics

  • Philippe Lemey mail,

    To whom correspondence should be addressed. E-mail: philippe.lemey@zoo.ox.ac.uk

    Affiliation: Department of Zoology, University of Oxford, Oxford, United Kingdom

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  • Sergei L Kosakovsky Pond,

    Affiliation: Department of Pathology, University of California San Diego, La Jolla, United States of America

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  • Alexei J Drummond,

    Affiliation: Department of Computer Science, University of Auckland, Auckland, New Zealand

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  • Oliver G Pybus,

    Affiliation: Department of Zoology, University of Oxford, Oxford, United Kingdom

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  • Beth Shapiro,

    Affiliation: Department of Zoology, University of Oxford, Oxford, United Kingdom

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  • Helena Barroso,

    Affiliations: Centro de Patogénese Molecular, Faculdade de Farmácia de Lisboa, Lisbon, Portugal, Instituto Superior de Ciências da Saúde Egas Moniz, Lisbon, Portugal

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  • Nuno Taveira,

    Affiliations: Centro de Patogénese Molecular, Faculdade de Farmácia de Lisboa, Lisbon, Portugal, Instituto Superior de Ciências da Saúde Egas Moniz, Lisbon, Portugal

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  • Andrew Rambaut

    Affiliation: Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: February 16, 2007
  • DOI: 10.1371/journal.pcbi.0030029

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