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Research Article

Modeling Cancer Progression via Pathway Dependencies

  • Elena J Edelman,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Computational Biology and Bioinformatics Program, Duke University, Durham, North Carolina, United States of America

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  • Justin Guinney,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Computational Biology and Bioinformatics Program, Duke University, Durham, North Carolina, United States of America

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  • Jen-Tsan Chi,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina

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  • Phillip G Febbo equal contributor,

    equal contributor Contributed equally to this work with: Phillip G Febbo, Sayan Mukherjee

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, Department of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Sayan Mukherjee equal contributor mail

    equal contributor Contributed equally to this work with: Phillip G Febbo, Sayan Mukherjee

    To whom correspondence should be addressed. E-mail: sayan@stat.duke.edu

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Statistical Science, Duke University, Durham, North Carolina, United States of America, Department of Computer Science, Duke University, Durham, North Carolina, United States of America

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  • Published: February 15, 2008
  • DOI: 10.1371/journal.pcbi.0040028

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