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Research Article

Numerical Analysis of Ca2+ Signaling in Rat Ventricular Myocytes with Realistic Transverse-Axial Tubular Geometry and Inhibited Sarcoplasmic Reticulum

  • Yuhui Cheng,

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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  • Zeyun Yu,

    Affiliation: Department of Computer Science, University of Wisconsin, Milwaukee, Wisconsin, United States of America

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  • Masahiko Hoshijima,

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Michael J. Holst,

    Affiliation: Department of Mathematics, University of California San Diego, La Jolla, California, United States of America

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  • Andrew D. McCulloch,

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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  • J. Andrew McCammon,

    Affiliations: Department of Chemistry and Biochemistry, Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America, Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America

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  • Anushka P. Michailova mail

    amihaylo@bioeng.ucsd.edu

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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  • Published: October 28, 2010
  • DOI: 10.1371/journal.pcbi.1000972

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