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Research Article

A Whole-Body Model for Glycogen Regulation Reveals a Critical Role for Substrate Cycling in Maintaining Blood Glucose Homeostasis

  • Ke Xu,

    Affiliations: Department of Biomedical Engineering, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America, Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

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  • Kevin T. Morgan,

    Affiliation: Old Dogs in Training, Carrboro, North Carolina, United States of America

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  • Abby Todd Gehris,

    Affiliation: Department of Mathematics, Broome Community College, Binghamton, New York, United States of America

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  • Timothy C. Elston mail,

    telston@amath.unc.edu (TCE); smgomez@unc.edu (SMG)

    Affiliation: Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • Shawn M. Gomez mail

    telston@amath.unc.edu (TCE); smgomez@unc.edu (SMG)

    Affiliations: Department of Biomedical Engineering, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America, Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America, Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Published: December 01, 2011
  • DOI: 10.1371/journal.pcbi.1002272

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