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Research Article

Exploring the Evolution of Novel Enzyme Functions within Structurally Defined Protein Superfamilies

  • Nicholas Furnham mail,

    nickf@ebi.ac.uk

    Affiliation: EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Ian Sillitoe,

    Affiliation: Institute of Structural and Molecular Biology, University College London, Darwin Building, London, United Kingdom

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  • Gemma L. Holliday,

    Affiliation: EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Alison L. Cuff,

    Affiliation: Institute of Structural and Molecular Biology, University College London, Darwin Building, London, United Kingdom

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  • Roman A. Laskowski,

    Affiliation: EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Christine A. Orengo,

    Affiliation: Institute of Structural and Molecular Biology, University College London, Darwin Building, London, United Kingdom

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  • Janet M. Thornton

    Affiliation: EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Published: March 01, 2012
  • DOI: 10.1371/journal.pcbi.1002403

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