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Research Article

A Two-Dimensional Model of the Colonic Crypt Accounting for the Role of the Basement Membrane and Pericryptal Fibroblast Sheath

  • Sara-Jane Dunn mail,

    sara-jane.dunn@microsoft.com

    Affiliations: Department of Computer Science, University of Oxford, Oxford, United Kingdom, Microsoft Research Ltd., Cambridge, United Kingdom

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  • Paul L. Appleton,

    Affiliation: College of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • Scott A. Nelson,

    Affiliation: College of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • Inke S. Näthke,

    Affiliation: College of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • David J. Gavaghan,

    Affiliations: Department of Computer Science, University of Oxford, Oxford, United Kingdom, Oxford Centre for Integrative Systems Biology, Department of Biochemistry, Oxford, United Kingdom

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  • James M. Osborne

    Affiliations: Department of Computer Science, University of Oxford, Oxford, United Kingdom, Oxford Centre for Integrative Systems Biology, Department of Biochemistry, Oxford, United Kingdom

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  • Published: May 24, 2012
  • DOI: 10.1371/journal.pcbi.1002515

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