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Research Article

Charge Profile Analysis Reveals That Activation of Pro-apoptotic Regulators Bax and Bak Relies on Charge Transfer Mediated Allosteric Regulation

  • Crina-Maria Ionescu,

    Affiliations: CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic, National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic

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  • Radka Svobodová Vařeková,

    Affiliations: CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic, National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic

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  • Jochen H. M. Prehn,

    Affiliations: Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

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  • Heinrich J. Huber,

    Affiliations: Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

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  • Jaroslav Koča mail

    jkoca@ceitec.muni.cz

    Affiliations: CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic, National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic

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  • Published: June 14, 2012
  • DOI: 10.1371/journal.pcbi.1002565

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