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Research Article

Multistationary and Oscillatory Modes of Free Radicals Generation by the Mitochondrial Respiratory Chain Revealed by a Bifurcation Analysis

  • Vitaly A. Selivanov mail,

    selivanov@ub.edu (VAS); martacascante@ub.edu (MC)

    Affiliations: Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain, Institute of Biomedicine of Universitat de Barcelona (IBUB) and CSIC-Associated Unit, Barcelona, Spain, A.N.Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia

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  • Marta Cascante mail,

    selivanov@ub.edu (VAS); martacascante@ub.edu (MC)

    Affiliations: Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain, Institute of Biomedicine of Universitat de Barcelona (IBUB) and CSIC-Associated Unit, Barcelona, Spain

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  • Mark Friedman,

    Affiliation: Mathematical Sciences Department, University of Alabama Huntsville, Huntsville, Alabama, United States of America

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  • Mark F. Schumaker,

    Affiliation: Department of Mathematics, Washington State University, Pullman, Washington, United States of America

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  • Massimo Trucco,

    Affiliation: Department of Pediatrics, The University of Pittsburgh School of Medicine and The Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Tatyana V. Votyakova

    Affiliation: Department of Pediatrics, The University of Pittsburgh School of Medicine and The Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Published: September 20, 2012
  • DOI: 10.1371/journal.pcbi.1002700

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