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Research Article

Dynamic Control of Selectivity in the Ubiquitination Pathway Revealed by an ASP to GLU Substitution in an Intra-Molecular Salt-Bridge Network

  • Sjoerd J. L. van Wijk equal contributor,

    equal contributor Contributed equally to this work with: Sjoerd J. L. van Wijk, Adrien S. J. Melquiond

    Affiliation: Department of Molecular Cancer Research, Division of Biomedical Genetics and Netherlands Proteomics Center, University Medical Center Utrecht, Utrecht, The Netherlands

    Current address: Institute of Biochemistry II and Buchman Institute for Molecular Life Sciences (FMLS), Goethe University School of Medicine, University Hospital, Frankfurt am Main, Germany.

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  • Adrien S. J. Melquiond equal contributor,

    equal contributor Contributed equally to this work with: Sjoerd J. L. van Wijk, Adrien S. J. Melquiond

    Affiliation: Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands

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  • Sjoerd J. de Vries,

    Affiliation: Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands

    Current address: Biomolecular Dynamics, Department of Physics T38, Technical University M√ľnchen, Garching, Germany.

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  • H. Th. Marc Timmers,

    Affiliation: Department of Molecular Cancer Research, Division of Biomedical Genetics and Netherlands Proteomics Center, University Medical Center Utrecht, Utrecht, The Netherlands

    X
  • Alexandre M. J. J. Bonvin mail

    A.M.J.J.Bonvin@uu.nl

    Affiliation: Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands

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  • Published: November 01, 2012
  • DOI: 10.1371/journal.pcbi.1002754

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