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Research Article

Computational Biomarker Pipeline from Discovery to Clinical Implementation: Plasma Proteomic Biomarkers for Cardiac Transplantation

  • Gabriela V. Cohen Freue,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada

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  • Anna Meredith,

    Affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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  • Derek Smith,

    Affiliation: University of Victoria Genome BC Proteomics Centre, Victoria, British Columbia, Canada

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  • Axel Bergman,

    Affiliation: Immunity and Infection Research Centre, Vancouver, British Columbia, Canada

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  • Mayu Sasaki,

    Affiliation: Immunity and Infection Research Centre, Vancouver, British Columbia, Canada

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  • Karen K. Y. Lam,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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  • Zsuzsanna Hollander,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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  • Nina Opushneva,

    Affiliation: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada

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  • Mandeep Takhar,

    Affiliation: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada

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  • David Lin,

    Affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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  • Janet Wilson-McManus,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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  • Robert Balshaw,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada

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  • Paul A. Keown,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada, Immunology Laboratory, Vancouver General Hospital, Vancouver, British Columbia, Canada

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  • Christoph H. Borchers,

    Affiliation: University of Victoria Genome BC Proteomics Centre, Victoria, British Columbia, Canada

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  • Bruce McManus,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada, UBC James Hogg Research Centre, Vancouver, British Columbia, Canada

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  • Raymond T. Ng mail,

    rmcmaster@exchange.ubc.ca

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Department of Computer Science, University of British Columbia, Vancouver, British Columbia, Canada

    RTN and WRM are joint senior authors on this work.

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  • W. Robert McMaster ,

    Affiliations: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada, Immunity and Infection Research Centre, Vancouver, British Columbia, Canada, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada

    RTN and WRM are joint senior authors on this work.

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  • for the Biomarkers in Transplantation and the NCE CECR Prevention of Organ Failure Centre of Excellence Teams

    Affiliation: NCE CECR Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada

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  • Published: April 04, 2013
  • DOI: 10.1371/journal.pcbi.1002963

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