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Table S3. Summary of experimental data on the effect of bacteria/mouse knockout mutations on bacterial clearance. This information was used to test the models outcomes in the corresponding simulated knockouts. For comparison the timing of the wild type infections is also given.
MutantSpeciesTiming of bacterial clearance (days post inoculation)ReferenceWild typeBb
Bp70
50 ADDIN EN.CITE Kirimanjeswara200319019126547847142003AprRole of antibodies in immunity to Bordetella infections1719-24Pathobiology Graduate Program, Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA.Kirimanjeswara, G. S.Mann, P. B.Harvill, E. T.Infect ImmunAnimalsAntibodies, Bacterial/*blood/*immunologyB-Lymphocytes/immunologyBordetella/*immunologyBordetella Infections/*immunology/microbiologyBordetella bronchiseptica/immunologyBordetella pertussis/immunologyDisease Models, AnimalHumansImmune Sera/immunologyImmunityMiceMice, Inbred BALB CResearch Support, U.S. Gov't, Non-P.H.S.Respiratory System/immunology/microbiologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12654784[1]Deletion of TTSSBb27 ADDIN EN.CITE Pilione200646046164287517422006FebThe Bordetella bronchiseptica type III secretion system inhibits gamma interferon production that is required for efficient antibody-mediated bacterial clearance1043-9Department of Veterinary and Biomedical Science, The Pennsylvania State University, 115 Henning, University Park, PA 16802, USA.Pilione, M. R.Harvill, E. T.Infect ImmunAnimalsAntibodies, Bacterial/blood/*immunologyBacterial Proteins/*secretionBordetella Infections/*immunology/microbiologyBordetella bronchiseptica/growth & development/immunology/*pathogenicityColony Count, MicrobialHumansInterferon Type II/*antagonists &inhibitors/deficiency/genetics/metabolismInterleukin-10/deficiency/genetics/metabolismLung/microbiologyMiceMice, Inbred C57BLResearch Support, N.I.H., ExtramuralSpleen/cytology/immunologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16428751[2]Deletion of PTXBp50 ADDIN EN.CITE Kirimanjeswara20053003016294220115122005DecPertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance of Bordetella pertussis3594-601Department of Veterinary and Biomedical Sciences and Department of Entomology, The Pennsylvania State University, University Park, Pennsylvania, USA.Kirimanjeswara, G. S.Agosto, L. M.Kennett, M. J.Bjornstad, O. N.Harvill, E. T.J Clin Investhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16294220[3]B cell deletionBb/BpBacterial persistence ADDIN EN.CITE Kirimanjeswara200319019126547847142003AprRole of antibodies in immunity to Bordetella infections1719-24Pathobiology Graduate Program, Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA.Kirimanjeswara, G. S.Mann, P. B.Harvill, E. T.Infect ImmunAnimalsAntibodies, Bacterial/*blood/*immunologyB-Lymphocytes/immunologyBordetella/*immunologyBordetella Infections/*immunology/microbiologyBordetella bronchiseptica/immunologyBordetella pertussis/immunologyDisease Models, AnimalHumansImmune Sera/immunologyImmunityMiceMice, Inbred BALB CResearch Support, U.S. Gov't, Non-P.H.S.Respiratory System/immunology/microbiologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12654784[1]Absence of adaptive immunityBb/BpBacterial persistence ADDIN EN.CITE Harvill1999260261053127467111999NovPregenomic comparative analysis between bordetella bronchiseptica RB50 and Bordetella pertussis tohama I in murine models of respiratory tract infection6109-18Department of Microbiology, University of California at Los Angeles School of Medicine, Los Angeles, California 90095-1747, USA.Harvill, E. T.Cotter, P. A.Miller, J. F.Infect ImmunAnimalsAntibodies, Bacterial/bloodApoptosisBlood Bactericidal ActivityBordetella Infections/*immunologyBordetella bronchiseptica/genetics/*immunology/pathogenicityBordetella pertussis/genetics/*immunology/pathogenicityCells, CulturedComparative StudyFemaleGenome, BacterialLung/pathologyLymphocytes/physiologyMacrophages/immunologyMiceMice, Inbred BALB CNeutrophils/physiologyRabbitsRespiratory Tract Infections/*complicationsVirulencehttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10531274[4]Antibody treatmentBb
Bp3
50 ADDIN EN.CITE Kirimanjeswara200319019126547847142003AprRole of antibodies in immunity to Bordetella infections1719-24Pathobiology Graduate Program, Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA.Kirimanjeswara, G. S.Mann, P. B.Harvill, E. T.Infect ImmunAnimalsAntibodies, Bacterial/*blood/*immunologyB-Lymphocytes/immunologyBordetella/*immunologyBordetella Infections/*immunology/microbiologyBordetella bronchiseptica/immunologyBordetella pertussis/immunologyDisease Models, AnimalHumansImmune Sera/immunologyImmunityMiceMice, Inbred BALB CResearch Support, U.S. Gov't, Non-P.H.S.Respiratory System/immunology/microbiologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12654784[1]
References
ADDIN EN.REFLIST 1. Kirimanjeswara GS, Mann PB, Harvill ET (2003) Role of antibodies in immunity to Bordetella infections. Infect Immun 71: 1719-1724.
2. Pilione MR, Harvill ET (2006) The Bordetella bronchiseptica type III secretion system inhibits gamma interferon production that is required for efficient antibody-mediated bacterial clearance. Infect Immun 74: 1043-1049.
3. Kirimanjeswara GS, Agosto LM, Kennett MJ, Bjornstad ON, Harvill ET (2005) Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance of Bordetella pertussis. J Clin Invest 115: 3594-3601.
4. Harvill ET, Cotter PA, Miller JF (1999) Pregenomic comparative analysis between bordetella bronchiseptica RB50 and Bordetella pertussis tohama I in murine models of respiratory tract infection. Infect Immun 67: 6109-6118.
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