Pathway Number Perou Sotiriou Vijver Wang Naderi MillerB West Sotiriou_JNCI OhiraNB HummelLYMPH ChenCG 41bbPathway 18 10 13 18 16 10 5 12 17 3 18 14 ace2Pathway 12 5 3 12 12 9 4 6 12 1 12 10 acetaminophenPathway 6 3 2 5 5 1 0 3 5 0 5 4 achPathway 15 10 7 15 15 4 6 9 14 4 14 12 actinYPathway 19 11 11 18 18 13 3 10 18 6 18 15 agpcrPathway 13 9 10 12 12 7 5 9 12 4 12 12 ahspPathway 13 9 8 12 12 8 1 6 12 2 12 10 aifPathway 4 2 1 2 3 3 2 1 3 1 3 3 akap13Pathway 11 6 7 10 10 4 4 4 10 3 10 10 akap96Pathway 12 10 11 12 12 4 5 7 12 6 12 9 akapCentrosomePathway 15 8 11 12 13 6 6 6 12 5 13 11 aktPathway 19 14 13 19 19 10 7 13 18 6 18 16 alkPathway 37 19 22 32 31 15 11 24 32 5 32 27 alternativePathway 9 7 3 9 9 6 1 7 9 0 9 4 amiPathway 24 18 15 24 23 16 6 18 23 6 23 21 anthraxPathway 2 2 2 2 2 1 1 2 2 0 2 2 appPathway 4 2 2 3 3 2 2 3 3 1 3 3 arapPathway 22 16 10 20 20 13 8 8 20 6 20 20 arenrf2Pathway 14 11 10 14 14 8 3 9 14 4 14 14 arfPathway 16 11 10 14 14 9 3 11 15 7 15 13 argininecPathway 6 4 5 6 6 4 0 2 6 2 6 4 asbcellPathway 12 5 4 12 12 7 1 7 8 0 8 5 at1rPathway 34 30 25 34 33 17 13 25 34 12 34 33 atmPathway 20 15 16 20 20 13 9 15 19 8 19 18 atrbrcaPathway 22 10 12 20 21 15 8 9 20 3 20 18 badPathway 22 18 16 22 22 10 10 18 22 5 22 20 bbcellPathway 8 5 4 8 8 3 1 4 4 0 4 4 bcl2family_and_reg_network 24 16 17 22 23 13 8 17 22 6 22 20 bcrPathway 35 26 28 35 33 17 10 25 34 13 34 33 betaoxidationPathway 6 3 5 6 6 3 0 3 6 3 6 5 biopeptidesPathway 39 28 25 38 38 16 10 27 38 13 38 33 blymphocytePathway 11 8 10 11 10 8 2 9 10 2 10 8 botulinPathway 5 2 1 5 4 2 1 3 4 3 4 3 breast_cancer_estrogen_signalling 101 76 68 100 98 65 23 67 95 22 95 86 ca_nf_at_signalling 100 54 57 96 95 43 29 64 90 21 93 80 cacamPathway 14 8 7 13 13 7 4 8 13 4 13 12 calcineurinPathway 19 15 12 19 18 11 8 17 18 10 18 18 cardiacegfPathway 18 13 12 17 17 11 6 9 17 4 17 16 carm1Pathway 13 11 11 13 13 7 4 10 13 4 13 13 carm-erPathway 30 20 16 27 26 18 8 17 25 4 25 26 caspase_activity 8 6 5 8 7 5 3 6 7 1 7 5 caspasePathway 23 14 15 21 19 15 7 14 22 3 22 20 cblPathway 13 10 9 13 12 5 5 8 12 0 12 11 ccr3Pathway 23 17 11 22 22 15 6 12 22 6 22 19 ccr5Pathway 18 14 10 18 18 11 3 13 18 7 18 17 cd40Pathway 15 10 12 15 14 10 6 8 13 4 13 13 cdc25Pathway 9 6 7 8 9 7 3 7 9 4 9 9 cdc42racPathway 15 11 12 14 14 8 5 10 14 6 14 12 cdk5Pathway 13 12 9 13 13 6 2 11 13 3 13 11 cdmacPathway 16 14 12 15 16 10 4 10 16 3 16 15 cell_adhesion 201 119 96 184 179 85 48 120 170 36 173 143 cell_adhesion_molecule_activity 120 71 54 109 107 58 35 71 103 23 104 94 cell_adhesion_receptor_activity 38 27 23 33 32 17 10 23 32 4 33 31 Cell_Cycle 84 55 52 80 74 55 23 51 74 27 76 70 cell_cycle_arrest 35 21 20 32 31 22 8 22 32 11 32 30 cell_cycle_checkpoint 26 17 16 25 26 17 7 18 24 7 24 22 cell_cycle_checkpointII 10 8 8 10 10 9 3 6 9 2 9 9 cell_cycle_regulator 26 20 19 25 25 20 6 18 24 10 24 22 cell_death 13 7 6 12 13 12 4 11 13 4 13 9 cell_growth_and_or_maintenance 71 40 27 65 64 39 20 38 60 15 59 55 cell_motility 118 69 57 111 106 60 30 66 104 24 105 86 cell_proliferation 232 114 98 215 212 111 58 129 204 37 206 164 cell_surface_receptor_linked_signal_transduction 145 64 61 135 135 66 34 77 130 16 130 104 cell2cellPathway 13 10 8 13 12 7 5 10 12 7 12 12 cellcyclePathway 23 20 19 23 22 16 7 20 23 10 23 21 ceramidePathway 22 17 17 21 21 11 10 17 22 8 22 20 cftrPathway 12 10 8 12 12 6 6 8 12 4 12 11 chemicalPathway 22 18 16 20 21 14 8 12 21 8 21 20 chrebpPathway 20 13 13 18 18 10 9 11 17 6 18 16 circadianPathway 6 4 3 6 6 4 2 4 6 0 6 6 ck1Pathway 17 12 12 16 16 6 6 12 16 6 16 13 classicPathway 14 10 3 12 12 10 2 6 12 2 12 10 Complement_Activation_Classical 16 11 3 14 15 11 2 7 13 2 14 11 compPathway 19 13 6 17 17 13 3 9 17 2 17 13 cptPathway 4 2 1 4 3 0 0 1 3 1 3 3 CR_ANGIOG 10 7 8 10 10 5 3 6 10 1 10 10 CR_CAM 95 70 64 93 91 49 28 76 91 17 91 85 CR_CANCER_TESTIS 12 2 1 10 10 2 1 3 11 1 11 4 CR_CELL_CYCLE 86 62 62 82 80 49 26 60 80 29 81 71 CR_CYTOSKELETON 25 19 18 23 23 14 9 17 23 7 23 21 CR_DEATH 76 41 42 73 74 43 20 49 71 15 71 65 CR_DNA_MET_AND_MOD 24 19 15 24 24 13 4 16 23 7 23 21 CR_HORMONAL_FUNCTIONS 12 2 4 12 12 7 4 10 12 2 12 9 CR_IMMUNE_FUNCTION 54 29 34 51 51 32 9 31 52 9 53 38 CR_PROTEIN_MOD 150 108 118 146 146 79 43 116 144 37 144 131 CR_REPAIR 41 23 28 39 39 22 8 27 38 15 37 33 CR_SIGNALLING 198 132 134 186 181 92 66 129 179 40 180 161 CR_TRANSCRIPTION_FACTORS 71 45 43 69 69 37 19 56 66 7 66 59 CR_TRANSPORT 7 6 6 6 6 2 2 5 6 1 6 6 CR_TRANSPORT_OF_VESICLES 26 13 13 24 23 12 8 19 23 10 23 21 crebPathway 27 23 20 27 27 11 8 20 27 7 27 26 cremPathway 7 4 2 7 7 3 3 4 7 2 7 5 cskPathway 24 18 15 24 23 16 6 18 23 6 23 21 ctla4Pathway 21 11 11 20 20 13 4 13 19 2 19 16 ctlPathway 15 8 8 15 12 9 1 11 12 3 12 10 cxcr4Pathway 24 20 15 24 23 13 6 20 23 9 23 22 cytokinePathway 22 4 6 20 20 6 1 12 20 1 21 11 d4gdiPathway 13 9 10 11 10 9 2 7 12 2 12 12 dbpbPathway 4 3 4 4 4 2 0 3 3 0 3 3 dcPathway 22 3 8 20 20 11 4 10 19 0 20 11 deathPathway 33 24 26 31 30 20 12 21 32 8 32 29 DNA_DAMAGE_SIGNALLING 95 59 58 93 91 56 25 58 89 25 89 81 dnafragmentPathway 10 8 5 10 10 8 4 6 10 3 10 9 dreamPathway 14 12 12 14 13 8 4 9 13 6 13 12 drug_resistance_and_metabolism 100 74 65 97 97 57 33 74 96 20 96 92 ecmPathway 23 19 16 21 20 10 5 13 21 8 21 20 edg1Pathway 26 22 16 25 25 8 8 19 25 8 25 23 eea1Pathway 7 6 5 7 7 6 3 6 7 1 7 7 EGF_receptor_signaling_pathway 14 8 8 12 12 6 3 8 12 2 12 13 egfPathway 27 22 21 27 26 16 8 19 27 10 27 25 egfr_smrtePathway 11 6 7 10 9 6 4 9 10 0 10 10 Eicosanoid_Synthesis 15 9 6 14 15 7 3 10 15 0 15 12 eif2Pathway 11 10 8 11 10 5 3 6 8 1 8 9 eif4Pathway 24 18 18 24 24 16 9 22 24 7 24 23 electron_transport 87 47 27 73 75 32 16 41 72 6 71 62 Electron_Transport_Chain 95 58 31 85 85 72 22 39 82 18 82 73 electron_transporter_activity 128 68 46 119 116 74 29 69 108 22 107 93 eosinophilsPathway 8 4 3 8 8 5 1 5 8 0 8 5 ephA4Pathway 10 8 7 9 9 5 5 5 9 5 9 9 eponfkbPathway 11 10 9 11 11 7 4 9 11 3 11 11 epoPathway 19 15 14 19 19 8 2 11 19 7 19 17 erbb3Pathway 5 4 2 5 5 2 3 4 5 2 5 5 erbb4Pathway 7 5 4 6 6 4 4 5 6 0 6 7 erk5Pathway 17 15 13 17 17 5 4 13 17 6 17 15 erkPathway 30 26 21 30 30 15 8 19 30 6 30 29 erythPathway 15 7 8 15 15 6 3 9 15 0 15 12 etcPathway 10 6 4 8 9 6 2 5 9 2 9 8 etsPathway 18 12 9 18 15 8 3 10 16 4 16 17 extrinsicPathway 13 10 8 13 13 5 2 8 13 0 13 13 fasPathway 30 22 24 29 27 14 9 20 27 8 27 24 Fatty_Acid_Degradation 25 14 14 19 19 11 4 14 19 5 18 18 fatty_acid_metabolism 26 18 14 25 25 15 10 14 25 4 25 21 Fatty_Acid_Synthesis 16 12 10 16 15 8 9 9 15 4 15 14 fbw7Pathway 9 8 5 9 9 8 3 8 9 4 9 8 fcer1Pathway 38 28 28 38 36 18 13 28 37 14 37 35 feederPathway 9 7 4 9 9 4 1 6 9 0 9 8 fibrinolysisPathway 12 12 10 12 12 4 2 6 12 4 12 12 flumazenilPathway 9 3 4 9 9 1 3 7 9 0 9 5 fmlppathway 37 29 25 37 35 15 13 29 36 12 36 33 fosbPathway 5 5 4 4 4 4 3 4 4 2 4 3 freePathway 10 6 8 10 10 6 4 8 10 2 10 9 fxrPathway 6 5 3 5 6 4 1 5 6 2 6 5 G13_Signaling_Pathway 34 22 18 28 28 19 16 21 28 8 28 29 g1Pathway 28 21 22 26 26 20 8 22 26 11 26 25 g1pPathway 3 1 1 3 3 2 1 2 3 1 3 3 g2Pathway 24 18 18 22 23 17 7 19 23 10 23 22 gabaPathway 12 6 5 12 11 2 5 5 11 1 11 8 gata3Pathway 16 11 12 16 15 6 5 13 15 5 15 13 gcrPathway 19 15 11 18 18 10 8 15 18 10 18 15 ghPathway 27 20 17 26 27 12 5 19 27 4 27 22 gleevecPathway 22 20 19 22 21 12 7 15 22 7 22 19 Glycogen_Metabolism 36 28 26 36 35 18 8 28 33 12 34 33 glycolysisPathway 10 7 6 10 10 6 4 8 9 4 9 9 gpcrPathway 35 28 24 35 34 19 14 28 34 16 34 33 GPCRs_Class_A_Rhodopsin-like 151 33 35 131 133 54 23 65 135 5 135 72 GPCRs_Class_A_Rhodopsin-like_2 13 2 4 8 10 2 5 1 9 1 9 8 GPCRs_Class_B_Secretin-like 24 5 2 23 23 8 5 16 23 3 24 15 GPCRs_Class_C_Metabotropic_glutamate_pheromone 14 4 2 14 14 3 4 6 13 0 13 9 gsk3Pathway 27 18 15 26 26 9 9 15 25 7 25 24 gsPathway 6 5 3 6 6 4 3 5 6 2 6 6 hbxPathway 8 7 5 8 8 3 2 3 8 2 8 8 hcmvPathway 16 15 15 16 15 6 5 15 16 6 16 15 hdacPathway 30 23 19 29 29 16 11 21 29 7 29 26 hifPathway 15 13 10 15 15 9 4 12 15 4 15 13 hivnefPathway 58 42 47 55 54 28 24 39 55 15 54 50 hsp27Pathway 16 8 10 13 14 7 4 8 15 2 15 14 huntingtonPathway 4 3 4 4 4 3 0 4 4 2 4 4 ifnaPathway 9 6 6 8 9 5 5 4 9 2 9 6 ifngPathway 6 5 3 6 5 5 3 2 5 2 6 6 igf1mtorPathway 20 16 17 20 20 10 7 16 20 6 20 20 igf1Pathway 20 19 18 20 20 11 6 15 20 7 20 19 igf1rPathway 15 15 12 15 15 6 5 11 15 4 15 14 il10Pathway 13 8 8 13 13 8 5 8 13 2 13 11 Il12Pathway 23 12 12 23 21 13 2 16 21 2 22 17 il17Pathway 17 10 9 17 16 7 2 13 16 2 16 13 il18Pathway 6 1 1 6 5 4 0 5 5 1 6 4 il1rPathway 33 22 24 32 31 12 10 18 32 5 32 30 il22bpPathway 13 7 6 12 12 8 7 6 12 1 12 10 il2Pathway 22 18 15 22 22 10 5 16 22 5 22 19 il2rbPathway 37 28 22 37 37 12 13 28 35 8 35 30 il3Pathway 15 12 10 15 15 6 1 8 15 3 15 11 il4Pathway 11 8 8 11 11 7 5 10 11 3 11 10 il5Pathway 10 6 4 10 10 6 2 6 10 0 10 7 il6Pathway 21 15 16 21 21 12 7 13 21 4 21 20 il7Pathway 16 14 13 16 16 9 7 15 16 3 16 15 Inflammatory_Response_Pathway 27 14 13 27 24 19 7 17 25 4 26 21 inflamPathway 29 10 14 28 28 11 5 16 28 1 29 20 insulin_signalling 103 70 62 102 101 52 33 68 97 18 98 82 insulinPathway 21 18 17 21 21 10 6 15 21 7 21 19 integrinPathway 38 28 26 34 33 18 15 21 32 12 32 30 intrinsicPathway 23 15 11 21 22 9 5 13 22 0 22 21 ionPathway 5 4 4 5 5 3 0 5 5 1 5 5 keratinocytePathway 46 34 36 46 45 19 15 33 44 10 44 40 ketonebodiesPathway 4 2 2 4 4 2 1 3 3 1 4 2 krebPathway 8 7 6 8 8 4 3 6 8 5 8 8 Krebs-TCA_Cycle 29 21 16 28 27 15 8 17 28 8 28 24 lairPathway 17 11 9 16 15 8 2 11 16 4 16 14 ldlPathway 6 4 3 6 6 3 1 3 6 1 6 5 lechtinPathway 12 7 4 11 11 6 2 5 11 0 11 9 leptinPathway 10 6 4 10 10 4 6 6 10 2 10 8 longevityPathway 14 12 10 14 14 10 5 9 14 5 14 13 lymphocytePathway 9 9 8 9 8 6 1 7 9 3 9 8 malatePathway 4 4 3 4 4 2 1 3 4 1 4 3 malatexPathway 8 7 7 8 8 4 2 5 8 2 8 7 MAP_kinase_activity 8 6 6 8 7 3 1 6 8 0 8 7 MAP_kinase_kinase_activity 8 7 7 8 8 1 2 6 8 1 8 8 MAP00010_Glycolysis_Gluconeogenesis 55 33 31 54 50 34 13 30 49 15 49 40 MAP00020_Citrate_cycle_TCA_cycle 18 15 13 18 17 12 4 11 18 6 18 17 MAP00030_Pentose_phosphate_pathway 19 11 9 18 16 10 8 10 16 7 16 16 MAP00051_Fructose_and_mannose_metabolism 25 14 11 24 23 13 7 13 23 4 23 19 MAP00052_Galactose_metabolism 24 9 11 24 23 12 4 15 23 4 23 17 MAP00062_Fatty_acid_biosynthesis_path_2 7 3 5 7 7 5 1 6 7 4 7 5 MAP00071_Fatty_acid_metabolism 50 28 29 46 45 21 5 29 45 11 43 34 MAP00100_Sterol_biosynthesis 10 7 7 10 10 4 2 9 10 5 10 9 MAP00120_Bile_acid_biosynthesis 23 12 13 23 22 10 4 17 22 5 21 16 MAP00140_C21_Steroid_hormone_metabolism 10 5 2 10 9 3 0 5 10 1 10 7 MAP00150_Androgen_and_estrogen_metabolism 18 10 4 17 16 7 3 12 17 0 17 15 MAP00190_Oxidative_phosphorylation 46 27 10 40 44 34 12 28 43 7 43 36 MAP00193_ATP_synthesis 19 10 0 16 18 13 6 8 18 5 18 16 MAP00195_Photosynthesis 20 10 0 17 19 13 6 8 19 5 19 17 MAP00220_Urea_cycle_and_metabolism_of_amino_groups 19 11 10 18 18 17 2 11 17 3 17 14 MAP00230_Purine_metabolism 84 48 43 82 81 50 24 50 82 16 82 73 MAP00240_Pyrimidine_metabolism 45 31 26 42 42 30 11 27 42 8 42 37 MAP00251_Glutamate_metabolism 21 13 11 21 20 11 6 18 20 4 20 18 MAP00252_Alanine_and_aspartate_metabolism 21 13 10 21 21 13 4 19 21 7 21 19 MAP00260_Glycine_serine_and_threonine_metabolism 24 20 18 24 22 13 7 16 22 5 22 20 MAP00271_Methionine_metabolism 8 6 6 8 8 4 2 8 8 1 8 8 MAP00272_Cysteine_metabolism 9 7 6 8 9 5 0 8 9 3 9 8 MAP00280_Valine_leucine_and_isoleucine_degradation 27 16 21 25 25 15 5 19 26 9 26 24 MAP00310_Lysine_degradation 17 10 10 17 16 11 2 8 16 7 16 12 MAP00330_Arginine_and_proline_metabolism 39 26 24 38 39 27 7 25 38 7 38 31 MAP00340_Histidine_metabolism 20 16 18 20 20 12 5 15 20 4 20 16 MAP00350_Tyrosine_metabolism 30 21 21 30 29 15 6 23 29 5 28 23 MAP00360_Phenylalanine_metabolism 16 12 13 16 16 8 3 15 16 2 16 13 MAP00361_gamma_Hexachlorocyclohexane_degradation 29 16 15 27 28 10 3 17 28 1 27 22 MAP00380_Tryptophan_metabolism 46 29 28 44 44 22 8 32 45 9 44 36 MAP00400_Phenylalanine_tyrosine_and_tryptophan_biosynthesis 8 5 4 8 8 5 2 6 8 4 8 6 MAP00410_beta_Alanine_metabolism 17 12 13 17 17 11 1 13 17 4 17 14 MAP00430_Taurine_and_hypotaurine_metabolism 4 2 0 4 4 0 2 3 4 0 4 3 MAP00450_Selenoamino_acid_metabolism 6 3 3 6 6 2 2 5 6 1 6 6 MAP00460_Cyanoamino_acid_metabolism 4 2 2 4 4 1 2 1 4 1 4 3 MAP00480_Glutathione_metabolism 22 16 18 22 21 12 7 14 21 1 20 19 MAP00500_Starch_and_sucrose_metabolism 23 15 10 23 22 11 5 16 22 3 22 18 MAP00510_N_Glycans_biosynthesis 18 13 9 17 17 9 6 10 16 5 16 14 MAP00512_O_Glycans_biosynthesis 10 1 1 8 8 7 5 3 8 2 7 5 MAP00530_Aminosugars_metabolism 14 6 4 14 14 9 2 6 13 1 13 9 MAP00531_Glycosaminoglycan_degradation 10 4 4 10 10 5 5 7 10 1 10 9 MAP00532_Chondroitin_Heparan_sulfate_biosynthesis 7 2 1 6 7 3 1 0 7 0 7 6 MAP00533_Keratan_sulfate_biosynthesis 8 5 4 8 7 2 1 4 6 1 6 5 MAP00561_Glycerolipid_metabolism 50 21 22 46 46 20 6 28 46 3 45 36 MAP00562_Inositol_phosphate_metabolism 20 12 10 20 19 11 4 15 19 2 18 17 MAP00590_Prostaglandin_and_leukotriene_metabolism 19 11 7 18 19 9 3 14 19 0 19 16 MAP00600_Sphingoglycolipid_metabolism 14 6 4 13 13 6 4 8 13 2 13 11 MAP00601_Blood_group_glycolipid_biosynthesis_lact_series 6 0 0 6 6 1 2 5 6 0 6 3 MAP00602_Blood_group_glycolipid_biosynthesis_neolact_series 14 4 3 14 14 4 4 8 13 1 13 9 MAP00603_Globoside_metabolism 11 2 4 10 10 4 3 6 10 1 9 6 MAP00620_Pyruvate_metabolism 31 18 16 31 30 20 5 15 30 9 31 26 MAP00630_Glyoxylate_and_dicarboxylate_metabolism 10 8 7 10 9 6 3 5 10 4 10 10 MAP00632_Benzoate_degradation 7 3 2 7 6 5 0 5 6 3 7 6 MAP00640_Propanoate_metabolism 20 12 13 19 19 12 1 12 20 8 20 17 MAP00650_Butanoate_metabolism 21 11 13 20 20 13 2 13 19 4 20 14 MAP00670_One_carbon_pool_by_folate 12 9 8 12 12 7 4 5 11 5 11 10 MAP00680_Methane_metabolism 7 5 5 7 7 3 2 3 7 3 7 5 MAP00710_Carbon_fixation 17 11 7 16 16 9 5 8 16 7 16 15 MAP00720_Reductive_carboxylate_cycle_CO2_fixation 7 5 5 7 7 7 1 6 7 4 7 7 MAP00740_Riboflavin_metabolism 6 4 4 5 5 3 1 3 5 0 5 5 MAP00760_Nicotinate_and_nicotinamide_metabolism 6 2 3 4 4 3 4 2 4 1 4 5 MAP00790_Folate_biosynthesis 12 7 7 11 12 5 3 7 12 4 12 11 MAP00860_Porphyrin_and_chlorophyll_metabolism 19 14 12 17 17 12 5 14 17 3 17 16 MAP00910_Nitrogen_metabolism 22 9 5 22 21 6 5 14 21 3 21 18 MAP00970_Aminoacyl_tRNA_biosynthesis 19 14 8 19 17 11 2 14 17 9 17 16 MAP03020_RNA_polymerase 17 11 6 16 16 11 5 8 17 3 17 13 MAP03070_Type_III_secretion_system 19 10 0 16 18 13 6 8 18 5 18 16 MAPK_Cascade 23 15 17 22 20 8 6 17 21 5 21 19 MAPKKK_cascade 9 7 7 8 9 2 2 8 9 1 9 6 mapkPathway 87 68 66 84 84 36 32 59 85 19 85 82 Matrix_Metalloproteinases 26 16 16 23 26 10 4 16 26 5 26 21 mcalpainPathway 25 19 16 23 23 13 11 17 23 6 23 22 mef2dPathway 21 16 12 20 18 14 7 16 18 8 18 19 methioninePathway 5 4 4 5 5 2 1 4 5 2 5 5 metPathway 36 31 31 34 34 17 15 23 34 11 34 31 mitochondriaPathway 21 14 12 20 20 12 8 10 21 2 21 18 mitrPathway 9 6 5 9 9 6 3 5 9 0 9 8 monocytePathway 11 10 9 11 10 7 1 9 11 3 11 10 mprPathway 23 18 14 22 23 9 10 18 23 8 23 20 mRNA_binding_activity 9 8 5 9 9 9 2 8 9 3 9 9 mRNA_processing 47 34 22 46 43 33 21 26 42 20 42 43 mRNA_splicing 58 37 22 52 50 36 15 29 49 15 48 45 mrpPathway 6 5 4 6 6 2 3 3 6 2 6 4 mspPathway 6 4 4 6 6 3 1 1 6 0 6 6 mta3Pathway 16 7 5 14 15 10 4 4 14 2 14 12 mtorPathway 23 16 15 23 22 15 7 17 23 11 23 22 muscle_myosin 15 5 3 15 15 10 0 10 14 1 14 8 myosinPathway 15 11 9 14 13 7 3 10 14 4 14 14 ndkDynaminPathway 19 14 11 17 18 13 6 13 18 9 18 16 neurotransmittersPathway 6 3 1 6 5 1 1 3 6 2 6 3 neutrophilPathway 8 8 8 8 7 6 1 7 8 2 8 7 nfatPathway 53 40 39 52 52 25 19 41 51 16 51 46 nfkbPathway 23 14 18 23 22 10 8 15 23 4 23 22 ngfPathway 19 16 14 19 19 9 3 13 19 8 19 18 nkcellsPathway 20 11 15 19 18 7 4 15 19 5 19 18 nktPathway 29 11 11 29 28 17 4 19 27 2 28 18 no1Pathway 31 21 16 29 29 16 11 24 29 10 29 26 no2il12Pathway 17 6 8 17 16 10 1 11 16 0 17 11 nos1Pathway 22 17 14 21 22 14 8 19 22 9 22 22 notchPathway 6 4 3 6 5 3 3 3 5 1 5 6 nthiPathway 24 16 20 22 22 13 7 14 22 5 22 22 ox40Pathway 3 0 1 3 3 2 0 2 3 0 3 0 p27Pathway 13 12 7 13 13 10 2 10 13 6 13 12 p35alzheimersPathway 11 8 9 10 10 4 6 9 10 5 10 9 p38mapkPathway 40 28 30 38 38 19 9 25 39 8 39 36 p53_signalling 101 68 61 94 95 64 34 62 93 23 93 86 p53hypoxiaPathway 20 14 13 19 20 10 7 14 20 11 20 17 p53Pathway 16 14 11 16 16 12 4 12 16 9 16 15 par1Pathway 21 16 12 20 20 7 6 13 20 6 20 20 parkinPathway 12 6 7 10 9 5 4 2 8 4 8 9 parkinsonsPathway 2 1 0 2 2 1 1 0 2 0 2 2 pdgfPathway 27 23 22 27 26 15 8 18 27 10 27 24 pelp1Pathway 7 7 4 6 7 3 3 5 7 0 7 6 Pentose_Phosphate_Pathway 7 5 2 7 6 5 4 4 7 2 7 6 pentosePathway 4 3 2 4 4 3 1 2 4 1 4 3 pepiPathway 8 3 4 7 7 4 1 6 7 2 7 5 pgc1aPathway 24 16 13 23 23 13 10 16 23 5 23 22 pitx2Pathway 16 9 7 16 16 5 4 10 16 4 16 14 pkcPathway 7 7 5 7 7 5 5 6 7 2 7 7 plcdPathway 5 3 3 5 5 3 0 4 5 0 5 4 plcePathway 12 8 7 11 12 6 7 7 12 4 12 11 plcPathway 8 6 6 8 8 3 2 7 8 3 8 8 plk3Pathway 8 6 6 7 7 5 3 3 7 1 7 7 pmlPathway 17 11 11 15 15 8 4 11 13 7 13 12 pparaPathway 57 47 39 54 54 31 19 41 54 13 53 48 ppargPathway 9 8 6 8 8 7 4 8 8 2 8 8 pparPathway 4 3 2 4 4 3 3 4 4 0 4 4 Proteasome_Degradation 32 17 12 32 30 25 5 24 31 8 32 29 proteasomePathway 21 14 10 21 20 18 4 18 20 6 21 20 ps1Pathway 14 8 5 13 13 4 7 7 13 2 13 11 ptc1Pathway 11 9 10 11 11 7 6 10 11 5 11 9 ptdinsPathway 23 13 17 20 20 12 11 17 20 11 20 20 ptenPathway 18 15 14 18 17 8 5 10 16 9 16 16 pyk2Pathway 29 24 20 29 27 11 8 21 28 12 28 27 rabPathway 12 9 7 11 11 7 2 9 11 6 11 11 rac1Pathway 22 19 17 22 20 14 7 19 22 7 22 20 raccycdPathway 23 22 18 22 22 12 7 19 22 12 22 20 radiation_sensitivity 27 22 21 27 27 17 11 21 24 9 24 23 ranklPathway 14 11 12 14 14 6 9 8 13 5 13 12 ranPathway 5 4 4 5 5 3 1 2 4 2 4 4 rarPathway 3 3 2 3 3 2 1 3 3 0 3 3 rarrxrPathway 15 14 10 15 14 10 6 11 15 2 15 15 rasPathway 23 18 17 22 22 9 8 18 22 8 22 21 rbPathway 13 10 10 12 13 10 3 9 13 8 13 13 reckPathway 9 7 6 9 9 5 1 5 9 4 9 9 reelinPathway 7 5 5 7 7 4 2 5 7 2 7 5 relaPathway 16 10 14 16 15 10 7 11 16 4 16 15 rhoPathway 31 22 18 30 29 16 10 17 30 7 30 27 rnaPathway 10 8 10 10 10 5 4 6 9 3 9 9 S1P_Signaling 25 16 10 21 21 9 6 16 23 6 23 20 s1pPathway 8 5 5 8 8 6 4 6 8 2 8 7 SA_B_CELL_RECEPTOR_COMPLEXES 24 19 19 24 23 11 8 14 24 5 24 23 SA_BONE_MORPHOGENETIC 7 2 6 4 4 3 2 4 4 2 4 4 SA_CASPASE_CASCADE 19 12 14 18 16 11 7 12 16 1 16 15 SA_DAG1 10 6 3 10 10 4 3 8 10 0 10 10 SA_FAS_SIGNALLING 9 7 7 9 9 4 4 8 7 2 7 7 SA_G1_AND_S_PHASES 15 10 8 15 15 11 4 9 15 9 15 12 SA_G2_AND_M_PHASES 8 6 8 8 8 8 2 6 8 5 8 8 SA_MMP_CYTOKINE_CONNECTION 15 10 11 14 15 5 6 11 14 2 15 13 SA_PROGRAMMED_CELL_DEATH 12 7 5 12 12 6 5 6 12 2 12 12 SA_PTEN_PATHWAY 17 14 10 17 17 8 6 13 17 6 17 16 SA_REG_CASCADE_OF_CYCLIN_EXPR 13 9 7 13 13 10 1 9 13 5 13 11 SA_TRKA_RECEPTOR 17 13 12 16 16 6 4 12 16 6 16 15 salmonellaPathway 12 9 9 12 12 9 4 7 12 4 12 10 sarsPathway 10 6 6 10 9 8 1 5 9 3 10 5 setPathway 11 7 4 11 10 8 2 7 11 2 11 10 shhPathway 16 9 9 15 15 8 8 11 14 5 14 13 SIG_BCR_Signaling_Pathway 46 35 36 44 45 22 15 36 45 11 45 44 SIG_CD40PATHWAYMAP 34 23 21 33 33 14 11 22 33 10 33 32 SIG_CHEMOTAXIS 45 28 22 43 42 23 20 25 42 13 42 37 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 27 20 18 26 27 11 13 21 27 6 27 26 SIG_InsulinReceptorPathwayInCardiacMyocytes 51 38 32 50 49 28 20 34 49 12 50 47 SIG_PIP3_signaling_in_B_lymphocytes 36 25 24 34 34 21 14 24 34 6 34 35 SIG_PIP3SIGINCARDIACMYOCTES 67 50 39 65 63 33 29 42 64 19 64 64 SIG_Regulation_of_the_actin_cytoskeleton_by_Rho_GTPases 35 19 15 34 33 19 14 15 33 13 33 26 skp2e2fPathway 10 8 6 10 10 8 2 10 10 4 10 9 slrp2Pathway 4 3 3 4 4 3 2 4 4 0 4 4 slrpPathway 6 4 4 6 6 4 2 4 6 1 6 6 soddPathway 10 7 9 10 9 5 5 7 10 2 10 9 sppaPathway 22 18 13 21 21 10 6 14 21 5 21 19 spryPathway 18 13 10 16 16 7 6 10 17 3 17 17 srcRPTPPathway 11 9 10 10 10 6 3 9 11 3 11 10 ST_ADRENERGIC 37 28 20 37 37 20 9 30 36 8 35 29 ST_B_Cell_Antigen_Receptor 40 27 29 38 39 16 12 27 39 9 39 39 ST_Dictyostelium_discoideum_cAMP_Chemotaxis_Pathway 33 20 16 32 31 15 9 21 31 6 31 28 ST_Dictyostelium_discoideum_cAMP_Receptor_G_Protein_Independent_Pathways 4 2 2 4 4 2 0 3 3 2 3 3 ST_Differentiation_Pathway_in_PC12_Cells 47 31 26 46 45 19 15 30 44 16 44 40 ST_ERK1_ERK2_MAPK_Pathway 32 27 25 31 31 14 12 25 29 5 29 27 ST_Fas_Signaling_Pathway 66 40 39 61 62 31 23 33 62 15 62 60 ST_G_alpha_5_Pathway 16 11 6 14 14 8 3 9 13 5 13 12 ST_G_alpha_i_Pathway_ 36 23 18 35 35 16 10 24 36 7 36 32 ST_G_Protein_Independent_7_Transmembrane 4 3 4 4 4 2 2 4 4 0 4 4 ST_G_Protein_Independent_7_Transmembrane_Receptor_Signaling 4 3 4 4 4 2 2 4 4 0 4 4 ST_Ga12_Pathway 23 17 17 23 23 11 8 13 23 4 23 21 ST_Ga13_Pathway 37 26 23 35 35 20 17 23 36 14 36 34 ST_Gaq_Pathway 28 19 13 27 28 16 11 21 28 7 28 26 ST_GRANULE_CELL_SURVIVAL_PATHWAY 28 20 17 27 27 15 9 20 27 8 27 26 ST_IL_13_PATHWAY 7 6 5 7 7 5 2 5 7 1 7 6 ST_Integrin_Signaling_Pathway 82 60 52 77 76 38 27 48 75 27 75 69 ST_Interferon_gamma_Pathway 10 9 6 10 8 7 5 3 7 2 9 10 ST_Interleukin_13_Pathway 7 6 5 7 7 5 2 5 7 1 7 6 ST_Interleukin_4_Pathway 26 20 16 24 26 17 10 16 25 5 26 24 ST_Jak_STAT_Pathway 9 7 5 9 9 5 4 5 8 0 9 8 ST_JNK_MAPK_Pathway 40 33 26 38 39 20 19 24 40 12 40 38 ST_MONOCYTE_AD_PATHWAY 28 16 14 27 27 14 5 20 26 7 26 18 ST_p38_MAPK_Pathway 37 28 24 36 35 17 11 25 36 9 36 37 ST_PAC1_RECEPTOR_PATHWAY 8 5 3 8 8 6 2 6 7 3 7 7 ST_Phosphoinositide_3_Kinase_Pathway 38 25 24 35 34 21 14 23 34 11 34 34 ST_STAT3_Pathway 11 7 7 11 11 6 7 5 10 0 11 10 ST_T_Cell_Signal_Transduction 45 22 23 41 42 19 14 23 42 9 43 40 ST_Tumor_Necrosis_Factor_Pathway 29 19 22 28 28 15 12 20 29 6 29 28 ST_Type_I_Interferon_Pathway 9 7 7 9 9 5 4 5 9 2 9 7 ST_Wnt_beta_catenin_Pathway 34 16 10 29 28 10 14 16 28 6 28 25 ST_Wnt_Ca2_cyclic_GMP_Pathway 20 10 9 20 20 9 3 14 20 1 20 18 stat3Pathway 8 5 4 8 8 4 3 6 8 0 8 6 stemPathway 15 4 7 15 15 6 2 9 15 1 15 10 stressPathway 25 15 22 25 24 12 8 16 25 5 25 24 tall1Pathway 15 9 12 14 13 6 6 8 13 3 13 13 tcapoptosisPathway 11 5 4 11 10 5 0 7 8 1 8 7 tcraPathway 13 9 7 13 12 9 2 9 12 3 12 10 tcrMoleculePathway 6 3 2 6 5 4 0 4 5 1 5 4 tcrPathway 46 33 34 46 43 25 14 34 44 18 44 41 tcytotoxicPathway 14 9 9 14 12 11 0 9 13 3 13 11 telPathway 18 15 15 18 18 12 4 13 17 8 16 14 tercPathway 6 5 5 6 6 1 1 6 6 4 6 6 tertPathway 8 7 7 8 8 2 0 5 8 3 8 7 TGF_Beta_Signaling_Pathway 45 24 24 36 33 22 18 22 34 11 35 33 tgfbPathway 19 13 13 14 14 10 3 11 14 1 14 13 th1th2Pathway 19 7 7 19 18 11 4 13 16 2 17 13 thelperPathway 14 9 8 14 12 11 0 10 13 3 13 11 tidPathway 19 13 12 18 17 12 6 8 17 5 18 16 tnf_and_fas_network 22 15 18 21 21 12 5 18 19 6 19 15 tnfr1Pathway 29 20 24 28 26 16 12 20 28 7 28 26 tnfr2Pathway 18 12 16 18 17 10 7 11 18 3 18 18 tob1Pathway 21 9 8 19 17 14 6 14 17 2 18 15 tollPathway 37 21 22 33 32 17 11 16 32 7 32 33 torPathway 3 2 2 3 3 3 0 3 3 1 3 3 tpoPathway 23 20 18 23 23 13 4 13 23 8 23 20 trkaPathway 14 11 9 14 14 6 2 9 14 5 14 13 tRNA_Synthetases 20 15 8 20 18 10 5 16 17 11 18 18 tsp1Pathway 7 7 7 7 7 5 3 5 7 4 7 7 tubbyPathway 7 3 1 7 6 2 4 5 6 2 6 6 tumor_supressor 26 20 18 25 22 14 7 16 22 8 22 22 ucalpainPathway 18 12 11 15 15 9 10 10 15 6 15 15 ureacyclePathway 7 5 4 7 7 5 1 5 7 0 7 7 vegfPathway 28 22 19 26 26 16 8 20 27 7 27 26 vifPathway 3 3 2 3 3 2 1 2 3 0 3 3 vipPathway 27 19 19 27 25 14 12 22 26 11 26 26 vitcbPathway 11 6 4 11 10 7 7 8 10 4 10 10 vobesityPathway 8 6 5 7 7 5 2 4 7 0 7 6 VOXPHOS 87 55 29 79 84 67 19 34 81 13 81 71 Wnt_Signaling 56 34 30 45 51 27 20 31 53 10 53 44 wntPathway 26 15 14 24 25 11 7 16 25 8 25 20 FA 23 16 18 21 22 14 4 14 20 5 19 17 GLUCO 32 18 14 31 31 19 10 17 30 11 30 26 GLYCOGEN 21 14 14 20 20 7 4 12 19 5 20 19 GLYCOL 22 13 8 21 21 11 6 10 20 8 20 18 GO_0005739 170 113 81 162 161 98 37 94 156 45 156 137 GO_ROS 28 18 13 27 28 15 8 17 26 3 26 26 human_mitoDB_6_2002 428 243 171 386 399 257 102 196 395 84 396 334 INS 28 19 17 25 25 13 10 17 25 5 25 23 KET 8 4 5 7 7 3 2 5 6 2 7 5 mitochondr 447 245 164 399 419 272 102 197 412 96 413 349 PGC 425 245 165 367 380 241 81 173 358 106 362 315 PYR 8 5 3 8 8 3 3 4 8 1 8 6 ROS 7 6 3 6 5 2 0 5 7 0 7 6 TCA 15 11 8 15 15 7 3 9 15 6 15 14 shh_lisa 18 11 12 18 16 7 6 17 16 9 17 15 MYC_WT 10 4 1 9 9 3 3 2 9 3 9 8 MYC_MUT 5 4 4 5 5 2 2 3 5 1 5 5 INSULIN_2F_DOWN 36 16 18 31 31 11 13 12 27 5 28 24 INSULIN_2F_UP 235 145 92 202 194 148 81 112 180 96 182 176 NFKB_INDUCED 111 79 67 108 107 53 28 78 106 28 106 95 NFKB_REDUCED 21 14 8 21 20 8 5 12 19 3 20 18 EMT_UP 57 39 34 55 56 39 16 37 55 19 55 50 EMT_DOWN 40 32 28 40 38 25 9 32 40 7 40 37 HTERT_DOWN 67 54 44 66 64 42 12 64 64 23 65 57 HTERT_UP 117 85 65 110 110 66 33 109 105 32 106 95 ANTI_CD44_UP 25 17 14 25 24 10 5 16 24 4 24 22 ANTI_CD44_DOWN 12 10 10 12 12 4 5 11 12 1 12 10 HOXA9_DOWN 39 33 29 38 36 23 12 25 33 14 34 36 P53_UP 40 31 24 40 40 25 4 39 37 9 36 35 P53_DOWN 19 12 12 17 15 13 10 16 16 4 17 16 RAP_UP 190 105 89 169 170 98 52 99 164 42 168 135 RAP_DOWN 229 140 103 213 209 129 54 140 196 82 201 174 GLUT_UP 296 169 136 265 259 149 83 146 247 89 250 215 GLUT_DOWN 313 195 143 284 287 182 66 174 268 101 269 234 LEU_UP 125 73 52 113 113 68 31 72 109 32 109 97 LEU_DOWN 180 120 94 165 166 107 46 109 153 67 155 130 GLUCOSE_UP 43 26 22 37 37 17 12 25 35 10 35 32 GLUCOSE_DOWN 157 98 77 148 147 92 37 91 140 64 140 117 BRCA_UP 42 36 28 40 40 29 16 36 40 17 40 40 BRCA_DOWN 13 8 4 12 12 10 1 11 12 2 12 9 FRASOR_ER_UP 32 18 15 30 30 22 10 14 30 6 30 27 FRASOR_ER_DOWN 74 46 36 69 65 45 17 41 65 15 64 56 ANDROGEN_UP_GENES 60 42 36 59 58 35 28 40 58 22 59 56 ANDROGEN_GENES_FROM_NETAFFX 62 31 17 54 56 21 14 27 55 9 55 46 AR_ORTHOS_MAPPED_TO_U133_VIA_NETAFFX 46 27 20 45 45 25 16 24 43 5 43 38 AR_MOUSE 46 27 20 45 45 25 16 24 43 5 43 38 AR_MOUSE_PLUS_TESTO_FROM_NETAFFX 62 34 25 58 61 33 19 31 58 5 58 48 XINACT_MERGED 21 10 5 20 19 10 7 13 21 7 21 19 TESTIS_GENES_FROM_XHX_AND_NETAFFX 73 26 17 61 72 34 11 21 66 6 67 46 GNF_FEMALE_GENES 85 47 38 85 83 56 32 56 83 29 84 70 GATA1_WEISS 24 17 13 24 23 13 5 11 24 3 24 21 HEMO_TF_LIST_JP 86 58 51 82 85 35 23 58 85 9 85 70 HOX_LIST_JP 56 23 13 48 55 25 17 26 53 6 53 35 HUMAN_CD34_ENRICHED_TF_JP 202 138 118 197 198 105 58 121 188 38 191 172 PROLIF_GENES 394 217 183 379 386 207 105 224 373 63 376 296 DOWNREG_BY_HOXA9 32 26 27 32 32 18 10 23 29 13 30 30 UPREG_BY_HOXA9 35 31 25 32 34 23 9 24 32 16 33 31 KRAS_TOP100_CONTROL 66 36 31 59 65 35 15 35 59 13 60 48 KRAS_TOP100_KNOCKDOWN 84 50 29 79 82 51 23 39 80 17 80 74 RAR_UP 35 25 19 35 35 28 13 20 34 13 34 32 ADULT_LIVER_vs_FETAL_LIVER_GNF2 80 47 34 73 76 38 10 35 73 5 73 54 FETAL_LIVER_HS_ENRICHED_TF_JP 81 51 36 78 81 31 22 47 78 17 78 64 CBF_LEUKEMIA_DOWNING_AML 75 44 37 66 74 36 15 40 67 13 68 62 MYCpathway 192 82 60 134 144 84 58 57 129 38 130 120 RASpathway 245 126 105 183 185 117 75 104 177 46 177 169 E2FApathway 233 94 58 157 161 96 73 57 151 42 154 158 SRCpathway 57 25 18 40 40 22 16 21 40 18 40 39 betaCATENINpathway 76 35 22 56 54 36 29 23 55 17 57 52 EGFR1-pathway 281 187 134 253 249 160 76 176 265 72 268 244 Hedgehog 25 14 11 18 18 13 9 11 20 5 20 19 Wnt-pathway 110 73 48 102 99 62 38 66 102 38 104 96 Delta-Notch 106 73 60 96 93 60 34 61 96 20 96 87 TNF-alpha-NF-kB 863 511 380 762 754 449 267 466 814 168 824 741 Androgen-Receptor 586 361 247 493 479 310 215 299 521 129 527 534 TGF-beta-receptor 1303 792 592 1177 1170 686 404 708 1238 266 1246 1143 Alpha6-Beta4-Integrin 31 29 24 30 30 17 8 25 31 9 30 24 Kit-receptor 76 55 50 71 72 44 14 54 73 12 73 64