HornbergInitialMaxScale6outputs.txt 0000444000076500007650000001246610653731147020305 0ustar apgarapgar00000000000000Num Concentration Scale Input Name EGFR2* Shc* Ras-GTP Raf* MEK-PP ERK-PP 1 8.00E-09 8.00E-09 1 EGF 0 0 0 0 0 0 2 5.00E+04 5.00E+04 0 EGFR 0 0 0 0 0 0 3 0.00E+00 4.30E+03 0 EGF-EGFR 0 0 0 0 0 0 4 0.00E+00 4.91E+02 0 (EGF-EGFR)2 2 0 0 0 0 0 5 0.00E+00 1.85E+04 0 (EGF-EGFR*)2 2 0 0 0 0 0 6 0.00E+00 8.99E+01 0 EGFRi 0 0 0 0 0 0 7 0.00E+00 5.42E+01 0 (EGF-EGFR*)2-GAP-Grb2-Prot 2 0 0 0 0 0 8 0.00E+00 2.20E+03 0 (EGF-EGFRi*)2 2 0 0 0 0 0 9 0.00E+00 4.34E-03 0 Proti 0 0 0 0 0 0 10 0.00E+00 3.49E+02 0 EGF-EGFRi 0 0 0 0 0 0 11 0.00E+00 2.16E+01 0 (EGF-EGFRi)2 2 0 0 0 0 0 12 8.10E+04 8.10E+04 0 Prot 0 0 0 0 0 0 14 1.20E+04 1.20E+04 0 GAP 0 0 0 0 0 0 15 0.00E+00 4.04E+02 0 (EGF-EGFR*)2-GAP 2 0 0 0 0 0 16 0.00E+00 1.99E+01 0 EGFi 0 0 0 0 0 0 17 0.00E+00 1.71E+02 0 (EGF-EGFRi*)2-GAP 2 0 0 0 0 0 18 0.00E+00 4.64E+01 0 (EGF-EGFRi*)2-GAP-Grb2 2 0 0 0 0 0 19 0.00E+00 2.35E+02 0 (EGF-EGFRi*)2-GAP-Grb2-Sos 2 0 0 0 0 0 20 0.00E+00 3.18E+01 0 (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP 2 0 0 0 0 0 21 0.00E+00 2.06E+01 0 (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP 2 0 0 0 0 0 22 1.10E+04 1.10E+04 0 Grb2 0 0 0 0 0 0 23 0.00E+00 6.63E+01 0 (EGF-EGFR*)2-GAP-Grb2 2 0 0 0 0 0 24 2.63E+04 2.63E+04 0 Sos 0 0 0 0 0 0 25 0.00E+00 4.63E+02 0 (EGF-EGFR*)2-GAP-Grb2-Sos 2 0 0 0 0 0 26 7.20E+04 7.20E+04 0 Ras-GDP 0 0 0 0 0 0 27 0.00E+00 2.47E+02 0 (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP 2 0 0 0 0 0 28 0.00E+00 1.41E+04 0 Ras-GTP 0 0 1 0 0 0 29 0.00E+00 1.42E+02 0 (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP 2 0 0 0 0 0 30 4.00E+04 4.55E+04 0 Grb2-Sos 0 0 0 0 0 0 31 1.01E+05 1.01E+05 0 Shc 0 0 0 0 0 0 32 0.00E+00 7.43E+01 0 (EGF-EGFR*)2-GAP-SHC 2 0 0 0 0 0 33 0.00E+00 5.28E+02 0 (EGF-EGFR*)2-GAP-SHC* 2 1 0 0 0 0 34 0.00E+00 6.00E+01 0 (EGF-EGFR*)2-GAP-SHC*-Grb2 2 1 0 0 0 0 35 0.00E+00 2.65E+03 0 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos 2 1 0 0 0 0 36 0.00E+00 1.58E+03 0 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP 2 1 0 0 0 0 37 0.00E+00 7.75E+02 0 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP 2 1 0 0 0 0 38 0.00E+00 3.47E+04 0 Shc*-Grb2-Sos 0 1 0 0 0 0 39 0.00E+00 3.69E+03 0 Shc*-Grb2 0 1 0 0 0 0 40 0.00E+00 4.51E+04 0 Shc* 0 1 0 0 0 0 41 4.00E+04 4.00E+04 0 Raf 0 0 0 0 0 0 42 0.00E+00 6.36E+02 0 Raf-Ras-GTP 0 0 1 0 0 0 43 0.00E+00 5.67E+04 0 Ras-GTP* 0 0 0 0 0 0 44 4.00E+04 4.00E+04 0 Phosphatase1 0 0 0 0 0 0 45 0.00E+00 1.24E+02 0 Raf* 0 0 0 1 0 0 46 0.00E+00 4.81E+02 0 Raf*-phosphatase1 0 0 0 1 0 0 47 2.10E+07 2.10E+07 0 MEK 0 0 0 0 0 0 48 0.00E+00 1.30E+04 0 MEK-Raf* 0 0 0 1 0 0 49 0.00E+00 4.47E+06 0 MEK-P 0 0 0 0 0 0 50 0.00E+00 2.06E+03 0 MEK-P-Raf* 0 0 0 1 0 0 51 0.00E+00 1.62E+05 0 MEK-PP 0 0 0 0 1 0 52 0.00E+00 1.82E+04 0 MEK-PP-phosphatase2 0 0 0 0 0 0 53 4.00E+04 4.00E+04 0 phosphatase2 0 0 0 0 0 0 54 0.00E+00 2.64E+04 0 MEK-P-phosphatase2 0 0 0 0 0 0 55 2.21E+07 2.21E+07 0 ERK 0 0 0 0 0 0 56 0.00E+00 1.48E+05 0 ERK-MEK-PP 0 0 0 0 0 0 57 0.00E+00 5.12E+06 0 ERK-P 0 0 0 0 0 0 58 0.00E+00 4.53E+05 0 ERK-P-MEK-PP 0 0 0 0 0 0 59 0.00E+00 1.14E+07 0 ERK-PP 0 0 0 0 0 1 60 1.00E+07 1.00E+07 0 phosphatase3 0 0 0 0 0 0 61 0.00E+00 9.81E+06 0 ERK-PP-phosphatase3 0 0 0 0 0 0 62 0.00E+00 8.67E+06 0 ERK-P-phosphatase3 0 0 0 0 0 0 63 0.00E+00 3.37E+01 0 (EGF-EGFRi*)2-GAP-SHC 2 0 0 0 0 0 64 0.00E+00 3.48E+02 0 (EGF-EGFRi*)2-GAP-SHC* 2 1 0 0 0 0 65 0.00E+00 3.63E+01 0 (EGF-EGFRi*)2-GAP-SHC*-Grb2 2 1 0 0 0 0 66 0.00E+00 1.05E+03 0 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos 2 1 0 0 0 0 67 0.00E+00 1.68E+02 0 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GDP 2 1 0 0 0 0 68 0.00E+00 8.77E+01 0 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GTP 2 1 0 0 0 0 69 0.00E+00 2.16E+03 0 Ras-GTPi 0 0 1 0 0 0 70 0.00E+00 8.45E+01 0 Raf-Ras-GTPi 0 0 1 0 0 0 71 0.00E+00 2.38E+04 0 Ras-GTPi* 0 0 0 0 0 0 72 0.00E+00 2.00E+01 0 Rafi* 0 0 0 1 0 0 73 0.00E+00 7.78E+01 0 Rafi*-phosphatase1 0 0 0 1 0 0 74 0.00E+00 1.88E+03 0 MEK-Rafi* 0 0 0 1 0 0 75 0.00E+00 8.76E+05 0 MEKi-P 0 0 0 0 0 0 76 0.00E+00 6.31E+01 0 MEK-P-Rafi* 0 0 0 1 0 0 77 0.00E+00 1.08E+04 0 MEKi-PP 0 0 0 0 1 0 78 0.00E+00 1.23E+03 0 MEKi-PP-phosphatase2 0 0 0 0 0 0 79 0.00E+00 5.44E+03 0 MEKi-P-phosphatase2 0 0 0 0 0 0 80 0.00E+00 3.84E+03 0 ERKi-MEKi-PP 0 0 0 0 0 0 81 0.00E+00 3.21E+05 0 ERKi-P 0 0 0 0 0 0 82 0.00E+00 5.80E+03 0 ERKi-P-MEKi-PP 0 0 0 0 0 0 83 0.00E+00 1.53E+05 0 ERKi-PP 0 0 0 0 0 1 84 0.00E+00 1.32E+05 0 ERKi-PP-phosphatase3 0 0 0 0 0 0 85 0.00E+00 1.81E+05 0 ERKi-P-phosphatase3 0 0 0 0 0 0 88 0.00E+00 2.73E+02 0 (EGF-EGFR*)2-GAP-Grb2-Sos-Prot 2 0 0 0 0 0 89 0.00E+00 1.04E+02 0 (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP-Prot 2 0 0 0 0 0 90 0.00E+00 9.13E+01 0 (EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP-Prot 2 0 0 0 0 0 91 0.00E+00 3.86E+01 0 (EGF-EGFR*)2-GAP-SHC*-Grb2-Prot 2 1 0 0 0 0 92 0.00E+00 1.55E+03 0 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Prot 2 1 0 0 0 0 93 0.00E+00 6.45E+02 0 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP-Prot 2 1 0 0 0 0 94 0.00E+00 4.62E+02 0 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP-Prot 2 1 0 0 0 0 95 0.00E+00 2.29E+02 0 (EGF-EGFR*)2-GAP-Grb2-Sos-ERK-PP 2 0 0 0 0 0 96 0.00E+00 2.75E+00 0 (EGF-EGFRi*)2-GAP-Grb2-Sos-ERKi-PP 2 0 0 0 0 0 97 0.00E+00 9.31E+02 0 (EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-ERK-PP 2 0 0 0 0 0 98 0.00E+00 1.10E+01 0 (EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-ERKi-PP 2 0 0 0 0 0 101 0.00E+00 1.05E+04 0 Sos-ERK-PP 0 0 0 0 0 0 102 0.00E+00 1.42E+02 0 Sos-ERKi-PP 0 0 0 0 0 0 103 0.00E+00 2.56E+03 0 Sosi 0 0 0 0 0 0 104 0.00E+00 1.00E+04 0 GAP-Ras-GTP 0 0 1 0 0 0 105 0.00E+00 1.00E+04 0 GAP-Ras-GTPi 0 0 1 0 0 0 106 0.00E+00 1.00E+04 0 GAP-Ras-GTP* 0 0 1 0 0 0 107 0.00E+00 1.00E+04 0 GAP-Ras-GTPi* 0 0 1 0 0 0 HornbergParamsProd.txt0000644000076500007650000001006310700512336015573 0ustar apgarapgar00000000000000Name Num Fwd Value Max Min Fixed k0 0 1 0.00E+00 0.00E+00 0.00E+00 1 kd0 0 0 0.00E+00 0.00E+00 0.00E+00 1 k1 1 1 3.00E+07 3.00E+08 3.00E+06 1 kd1 1 0 3.84E-03 3.84E-02 3.84E-04 1 k10b 10 1 5.43E-02 5.43E-01 5.43E-03 1 kd10 10 0 1.10E-02 1.10E-01 1.10E-03 1 k2 2 1 1.66E-05 1.66E-04 1.66E-06 1 kd2 2 0 1.00E-01 1.00E+00 1.00E-02 1 k3 3 1 1.00E+00 1.00E+01 1.00E-01 1 kd3 3 0 1.00E-02 1.00E-01 1.00E-03 1 k4 4 1 1.73E-07 1.73E-06 1.73E-08 1 kd4 4 0 1.66E-03 1.66E-02 1.66E-04 1 kd5 5 0 1.48E-02 1.48E-01 1.48E-03 1 k5 5 1 0.00E+00 0.00E+00 0.00E+00 1 k6 6 1 5.00E-04 5.00E-03 5.00E-05 1 kd6 6 0 5.00E-03 5.00E-02 5.00E-04 1 k8 8 1 1.66E-06 1.66E-05 1.66E-07 1 kd8 8 0 2.00E-01 2.00E+00 2.00E-02 1 k13 13 1 2.17E+00 2.17E+01 2.17E-01 1 kd13 13 0 0.00E+00 0.00E+00 0.00E+00 1 k15 15 1 1.00E+04 1.00E+05 1.00E+03 1 kd15 15 0 0.00E+00 0.00E+00 0.00E+00 1 k16 16 1 1.66E-05 1.66E-04 1.66E-06 1 kd16 16 0 0.00E+00 0.00E+00 0.00E+00 1 k17 17 1 1.66E-05 1.66E-04 1.66E-06 1 kd17 17 0 6.00E-02 6.00E-01 6.00E-03 1 k18 18 1 2.50E-05 2.50E-04 2.50E-06 1 kd18 18 0 1.30E+00 1.30E+01 1.30E-01 1 k19 19 1 1.66E-07 1.66E-06 1.66E-08 1 kd19 19 0 5.00E-01 5.00E+00 5.00E-02 1 k20 20 1 3.50E-06 3.50E-05 3.50E-07 1 kd20 20 0 4.00E-01 4.00E+00 4.00E-02 1 k21 21 1 3.66E-07 3.66E-06 3.66E-08 1 kd21 21 0 2.30E-02 2.30E-01 2.30E-03 1 k22 22 1 3.50E-05 3.50E-04 3.50E-06 1 kd22 22 0 1.00E-01 1.00E+00 1.00E-02 1 k23 23 1 6.00E+00 6.00E+01 6.00E-01 1 kd23 23 0 6.00E-02 6.00E-01 6.00E-03 1 kd24 24 0 5.50E-01 5.50E+00 5.50E-02 1 k25 25 1 1.66E-05 1.66E-04 1.66E-06 1 kd25 25 0 2.14E-02 2.14E-01 2.14E-03 1 k28 28 1 1.66E-06 1.66E-05 1.66E-07 1 kd28 28 0 5.30E-03 5.30E-02 5.30E-04 1 k29 29 1 1.17E-06 1.17E-05 1.17E-07 1 kd29 29 0 1.00E+00 1.00E+01 1.00E-01 1 kd32 32 0 1.00E-01 1.00E+00 1.00E-02 1 k32 32 1 4.00E-07 4.00E-06 4.00E-08 1 kd33 33 0 2.00E-01 2.00E+00 2.00E-02 1 k33 33 1 3.50E-05 3.50E-04 3.50E-06 1 kd34 34 0 3.00E-02 3.00E-01 3.00E-03 1 k34 34 1 7.50E-06 7.50E-05 7.50E-07 1 kd35 35 0 1.50E-03 1.50E-02 1.50E-04 1 k35 35 1 7.50E-06 7.50E-05 7.50E-07 1 k36 36 1 5.00E-03 5.00E-02 5.00E-04 1 kd36 36 0 0.00E+00 0.00E+00 0.00E+00 1 kd37 37 0 3.00E-01 3.00E+00 3.00E-02 1 k37 37 1 1.50E-06 1.50E-05 1.50E-07 1 k40 40 1 5.00E-05 5.00E-04 5.00E-06 1 kd40 40 0 6.40E-02 6.40E-01 6.40E-03 1 k41 41 1 5.00E-05 5.00E-04 5.00E-06 1 kd41 41 0 4.29E-02 4.29E-01 4.29E-03 1 k42 42 1 1.18E-04 1.18E-03 1.18E-05 1 kd42 42 0 2.00E-01 2.00E+00 2.00E-02 1 kd43 43 0 1.00E+00 1.00E+01 1.00E-01 1 k43 43 1 0.00E+00 0.00E+00 0.00E+00 1 kd44 44 0 1.83E-02 1.83E-01 1.83E-03 1 kd45 45 0 3.50E+00 3.50E+01 3.50E-01 1 k45 45 1 0.00E+00 0.00E+00 0.00E+00 1 kd47 47 0 2.90E+00 2.90E+01 2.90E-01 1 k47 47 1 0.00E+00 0.00E+00 0.00E+00 1 k48 48 1 2.38E-05 2.38E-04 2.38E-06 1 kd48 48 0 8.00E-01 8.00E+00 8.00E-02 1 kd49 49 0 5.80E-02 5.80E-01 5.80E-03 1 k49 49 1 0.00E+00 0.00E+00 0.00E+00 1 k50 50 1 4.50E-07 4.50E-06 4.50E-08 1 kd50 50 0 5.00E-01 5.00E+00 5.00E-02 1 kd52 52 0 3.30E-02 3.30E-01 3.30E-03 1 kd53 53 0 1.60E+01 1.60E+02 1.60E+00 1 k53 53 1 0.00E+00 0.00E+00 0.00E+00 1 kd55 55 0 5.70E+00 5.70E+01 5.70E-01 1 k55 55 1 0.00E+00 0.00E+00 0.00E+00 1 kd56 56 0 6.00E-01 6.00E+00 6.00E-02 1 k56 56 1 2.35E-05 2.35E-04 2.35E-06 1 kd57 57 0 2.46E-01 2.46E+00 2.46E-02 1 k57 57 1 0.00E+00 0.00E+00 0.00E+00 1 k58 58 1 8.33E-06 8.33E-05 8.33E-07 1 kd58 58 0 5.00E-01 5.00E+00 5.00E-02 1 k52 52 1 8.91E-05 8.91E-04 8.91E-06 1 k44 44 1 1.96E-05 1.96E-04 1.96E-06 1 k60 60 1 5.50E-03 5.50E-02 5.50E-04 1 kd60 60 0 0.00E+00 0.00E+00 0.00E+00 1 k61 61 1 6.70E-04 6.70E-03 6.70E-05 1 kd61 61 0 0.00E+00 0.00E+00 0.00E+00 1 kd63 63 0 2.75E-01 2.75E+00 2.75E-02 1 k63 63 1 0.00E+00 0.00E+00 0.00E+00 1 k126 126 1 1.66E-07 1.66E-06 1.66E-08 1 kd126 126 0 2.00E+00 2.00E+01 2.00E-01 1 kd127 127 0 1.00E-04 1.00E-03 1.00E-05 1 k127 127 1 0.00E+00 0.00E+00 0.00E+00 1 k200 200 0 2.17E+00 2.17E+01 2.17E-01 1 kd214 214 1 1.81E-04 1.81E-03 1.81E-05 1 kd222 222 1 1.97E-04 1.97E-03 1.97E-05 1 kd224 224 1 8.25E-05 8.25E-04 8.25E-06 1 kd226 226 1 3.01E-05 3.01E-04 3.01E-06 1 kd231 231 1 3.00E-05 2.15E-04 2.15E-06 1 kd230 230 1 5.43E-05 5.43E-04 5.43E-06 1 k300 300 1 1.00E-07 1.00E-07 1.00E-07 1HornbergRxn.txt0000644000076500007650000003652610700512525014306 0ustar apgarapgar00000000000000Num Fwd R1 R2 Rev P Step Include ProcessDescription RxnDescription 001 001 001 002 001 003 001 1 receptor_activation [EGFR]+[EGF] ? [EGF-EGFR] 002 002 003 003 002 004 001 1 receptor_activation [EGF-EGFR]+[EGF-EGFR] ? [(EGF-EGFR)2] 003 003 004 000 003 005 001 1 receptor_activation [(EGF-EGFR)2] ? [(EGF-EGFR*)2] 010 010 006 016 010 010 001 1 receptor_activation [EGFRi]+[EGFi] ? [EGF-EGFRi] 011 002 010 010 002 011 001 1 receptor_activation [EGF-EGFRi]+[EGF-EGFRi] ? [(EGF-EGFRi)2] 012 003 011 000 003 008 001 1 receptor_activation [(EGF-EGFRi)2] ? [(EGF-EGFRi*)2] 013 013 000 000 013 002 001 1 receptor_activation ? [EGFR] 008 008 005 014 008 015 002 1 recruitment [(EGF-EGFR*)2]+[GAP] ? [(EGF-EGFR*)2-GAP] 016 016 022 015 063 023 002 1 recruitment [(EGF-EGFR*)2-GAP]+[Grb2] ? [(EGF-EGFR*)2-GAP-Grb2] 017 017 024 023 017 025 002 1 recruitment [(EGF-EGFR*)2-GAP-Grb2]+[Sos] ? [(EGF-EGFR*)2-GAP-Grb2-Sos] 022 022 031 015 022 032 002 1 recruitment [(EGF-EGFR*)2-GAP]+[Shc] ? [(EGF-EGFR*)2-GAP-Shc] 023 023 032 000 023 033 002 1 recruitment [(EGF-EGFR*)2-GAP-Shc] ? [(EGF-EGFR*)2-GAP-Shc*] 024 016 022 033 024 034 002 1 recruitment [(EGF-EGFR*)2-GAP-Shc*]+[Grb2] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2] 025 025 024 034 025 035 002 1 recruitment [(EGF-EGFR*)2-GAP-Shc*-Grb2]+[Sos] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos] 032 032 015 038 032 035 002 1 recruitment [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos] ? [(EGF-EGFR*)2-GAP]+[Shc*-Grb2-Sos] 033 033 040 030 033 038 002 1 recruitment [Shc*-Grb2-Sos] ? [Grb2-Sos]+[Shc*] 034 034 015 030 034 025 002 1 recruitment [(EGF-EGFR*)2-GAP-Grb2-Sos] ? [(EGF-EGFR*)2-GAP]+[Grb2-Sos] 035 035 024 022 035 030 002 1 recruitment [Grb2-Sos] ? [Grb2] +[Sos] 036 036 040 000 036 031 002 1 recruitment [Shc*] ? [Shc] 037 037 015 040 037 033 002 1 recruitment [(EGF-EGFR*)2-GAP-Shc*] ? [(EGF-EGFR*)2-GAP]+[Shc*] 038 016 022 040 024 039 002 1 recruitment [Shc*]+[Grb2] ? [Shc*-Grb2] 039 037 015 039 037 034 002 1 recruitment [(EGF-EGFR*)2-GAP-Shc*-Grb2] ? [(EGF-EGFR*)2-GAP]+[Shc*-Grb2] 040 040 024 039 040 038 002 1 recruitment [Shc*-Grb2]+[Sos] ? [Shc*-Grb2-Sos] 041 041 030 033 041 035 002 1 recruitment [(EGF-EGFR*)2-GAP-Shc*] + [Grb2-Sos] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos] 063 016 017 022 063 018 002 1 recruitment [(EGF-EGFRi*)2-GAP]+[Grb2] ? [(EGF-EGFRi*)2-GAP-Grb2] 064 017 024 018 017 019 002 1 recruitment [(EGF-EGFRi*)2-GAP-Grb2]+[Sos] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos] 069 022 031 017 022 063 002 1 recruitment [(EGF-EGFRi*)2-GAP]+[Shc] ? [(EGF-EGFRi*)2-GAP-Shc] 070 023 063 000 023 064 002 1 recruitment [(EGF-EGFR*)2-GAP-Shc] ? [(EGF-EGFR*)2-GAP-Shc*] 071 016 022 064 024 065 002 1 recruitment [(EGF-EGFRi*)2-GAP-Shc*]+[Grb2] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2] 072 025 024 065 025 066 002 1 recruitment [(EGF-EGFRi*)2-GAP-Shc*-Grb2]+[Sos] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] 079 032 017 038 032 066 002 1 recruitment [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] ? [(EGF-EGFRi*)2-GAP]+[Shc-Grb2-Sos] 080 034 017 030 034 019 002 1 recruitment [(EGF-EGFRi*)2-GAP-Grb2-Sos] ? [(EGF-EGFRi*)2-GAP]+[Grb2-Sos] 081 037 017 040 037 064 002 1 recruitment [(EGF-EGFRi*)2-GAP-Shc*] ? [(EGF-EGFRi*)2-GAP]+[Shc*] 082 037 017 039 037 065 002 1 recruitment [(EGF-EGFRi*)2-GAP-Shc*-Grb2] ? [(EGF-EGFRi*)2-GAP]+[Shc*-Grb2] 083 041 030 064 041 066 002 1 recruitment [(EGF-EGFRi*)2-GAP-Shc*] + [Grb2-Sos] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] 018 018 026 025 018 027 003 1 Ras_activation [(EGF-EGFR*)2-GAP-Grb2-Sos]+[Ras-GDP] ? [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP] 019 019 028 025 019 027 003 1 Ras_activation [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP] ? [(EGF-EGFR*)2-GAP-Grb2-Sos]+[Ras-GTP] 026 018 026 035 018 036 003 1 Ras_activation [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos]+[Ras-GDP] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] 027 019 035 028 019 036 003 1 Ras_activation [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos] + [Ras-GTP] 065 018 026 019 018 020 003 1 Ras_activation [(EGF-EGFRi*)2-GAP-Grb2-Sos]+[Ras-GDP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP] 066 019 069 019 019 020 003 1 Ras_activation [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos]+[Ras-GTPi] 073 018 026 066 018 067 003 1 Ras_activation [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos]+[Ras-GDP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] 074 019 066 069 019 067 003 1 Ras_activation [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] + [Ras-GTPi] 028 028 028 041 028 042 004 1 Ras_activates_Raf [Raf]+[Ras-GTP] ? [Raf-Ras-GTP] 029 029 043 045 029 042 004 1 Ras_activates_Raf [Raf-Ras-GTP] ? [Raf*]+[Ras-GTP*] 075 028 069 041 028 070 004 1 Ras_activates_Raf [Raf]+[Ras-GTPi] ? [Raf-Ras-GTPi] 076 029 071 072 029 070 004 1 Ras_activates_Raf [Raf-Ras-GTPi] ? [Rafi*]+[Ras-GTPi*] 014 008 008 014 008 017 005 1 Ras_inactivation [(EGF-EGFRi*)2]+ [GAP] ? [(EGF-EGFRi*)2-GAP] 020 020 025 043 020 029 005 1 Ras_inactivation [Ras-GTP*]+[(EGF-EGFR*)2-GAP-Grb2-Sos] ? [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP] 021 021 025 026 021 029 005 1 Ras_inactivation [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP] ? [(EGF-EGFR*)2-GAP-Grb2-Sos]+[Ras-GDP] 030 020 035 043 020 037 005 1 Ras_inactivation [Ras-GTP*]+[(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] 031 021 035 026 021 037 005 1 Ras_inactivation [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos]+[Ras-GDP] 067 020 071 019 020 021 005 1 Ras_inactivation [Ras-GTPi*]+[(EGF-EGFRi*)2-GAP-Grb2-Sos] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTPi] 068 021 019 026 021 021 005 1 Ras_inactivation [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos]+[Ras-GDP] 077 020 071 066 020 068 005 1 Ras_inactivation [Ras-GTPi*]+[(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] 078 021 066 026 021 068 005 1 Ras_inactivation [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos]+[Ras-GDP] 044 044 047 045 052 048 006 1 Raf_phosphorylates_MEK [MEK] + [Raf*] ? [MEK-Raf*] 045 045 049 045 045 048 006 1 Raf_phosphorylates_MEK [MEK-Raf*] ? [MEK-P] +[Raf*] 046 044 049 045 052 050 006 1 Raf_phosphorylates_MEK [MEK-P]+[Raf*] ? [MEK-P-Raf*] 047 047 051 045 047 050 006 1 Raf_phosphorylates_MEK [MEK-P-Raf*] ? [MEK-PP] + [Raf*] 086 044 047 072 052 074 006 1 Raf_phosphorylates_MEK [MEK] + [Rafi*] ? [MEK-Rafi*] 087 045 075 072 045 074 006 1 Raf_phosphorylates_MEK [MEK-Rafi*] ? [MEKi-P] +[Rafi*] 088 044 072 075 052 076 006 1 Raf_phosphorylates_MEK [MEKi-P]+[Rafi*] ? [MEK-P-Rafi*] 089 047 072 077 047 076 006 1 Raf_phosphorylates_MEK [MEK-P-Rafi*] ? [MEKi-PP] + [Rafi*] 042 042 044 045 042 046 007 1 Raf_dephosphorylation [Raf*]+[Phosphatase1] ? [Raf*-Phosphatase1] 043 043 041 044 043 046 007 1 Raf_dephosphorylation [Raf*-Phosphatase1] ? [Raf]+[Phosphatase1] 084 042 044 072 042 073 007 1 Raf_dephosphorylation [Rafi*]+[Phosphatase1] ? [Rafi*-Phosphatase1] 085 043 041 044 043 073 007 1 Raf_dephosphorylation [Rafi*-Phosphatase1] ? [Raf]+[Phosphatase1] 048 048 051 053 048 052 008 1 MEK_dephosphorylation [MEK-PP]+[Phosphatase2] ? [MEK-PP-Phosphatase2] 049 049 049 053 049 052 008 1 MEK_dephosphorylation [MEK-PP-Phosphatase2] ? [MEK-P] + [Phosphatase2] 050 050 053 049 050 054 008 1 MEK_dephosphorylation [MEK-P]+[Phosphatase2] ? [MEK-P-Phosphatase2] 051 049 047 053 049 054 008 1 MEK_dephosphorylation [MEK-P-Phosphatase2] ? [MEK]+[Phosphatase2] 090 048 077 053 048 078 008 1 MEK_dephosphorylation [MEKi-PP]+[Phosphatase2] ? [MEKi-PP-Phosphatase2] 091 049 075 053 049 078 008 1 MEK_dephosphorylation [MEKi-PP-Phosphatase2] ? [MEKi-P] + [Phosphatase2] 092 050 053 075 050 079 008 1 MEK_dephosphorylation [MEKi-P]+[Phosphatase2] ? [MEKi-P-Phosphatase2] 093 049 047 053 049 079 008 1 MEK_dephosphorylation [MEKi-P-Phosphatase2] ? [MEK]+[Phosphatase2] 052 052 055 051 044 056 009 1 ERK_phosphorylation [ERK]+[MEK-PP] ? [ERK-MEK-PP] 053 053 051 057 053 056 009 1 ERK_phosphorylation [ERK-MEK-PP] ? [ERK-P]+[MEK-PP] 054 052 051 057 044 058 009 1 ERK_phosphorylation [ERK-P]+[MEK-PP] ? [ERK-P-MEK-PP] 055 055 059 051 055 058 009 1 ERK_phosphorylation [ERK-P-MEK-PP] ? [ERK-PP]+[MEK-PP] 094 052 055 077 044 080 009 1 ERK_phosphorylation [ERK]+[MEKi-PP] ? [ERK-MEKi-PP] 095 053 081 077 053 080 009 1 ERK_phosphorylation [ERK-MEKi-PP] ? [ERKi-P]+[MEKi-PP] 096 052 077 081 044 082 009 1 ERK_phosphorylation [ERKi-P]+[MEKi-PP] ? [ERKi-P-MEKi-PP] 097 055 083 077 055 082 009 1 ERK_phosphorylation [ERKi-P-MEKi-PP] ? [ERKi-PP]+[MEKi-PP] 056 056 059 060 056 061 010 1 ERK_dephosphorylation [ERK-PP]+[Phosphatase3] ? [ERK-PP-Phosphatase3] 057 057 057 060 057 061 010 1 ERK_dephosphorylation [ERK-PP-Phosphatase3] ? [ERK-P]+[Phosphatase3] 058 058 060 057 058 062 010 1 ERK_dephosphorylation [ERK-P] + [Phosphatase3] ? [ERK-P-Phosphatase3] 059 057 055 060 057 062 010 1 ERK_dephosphorylation [ERK-P-Phosphatase3] ? [ERK]+[Phosphatase3] 098 056 083 060 056 084 010 1 ERK_dephosphorylation [ERKi-PP]+[Phosphatase3] ? [ERKi-PP-Phosphatase3] 099 057 081 060 057 084 010 1 ERK_dephosphorylation [ERKi-PP-Phosphatase3] ? [ERKi-P]+[Phosphatase3] 100 058 060 081 058 085 010 1 ERK_dephosphorylation [ERKi-P] + [Phosphatase3] ? [ERKi-P-Phosphatase3] 101 057 055 060 057 085 010 1 ERK_dephosphorylation [ERKi-P-Phosphatase3] ? [ERK]+[Phosphatase3] 126 126 059 025 126 095 011 1 negative_feedback_loop [(EGF-EGFR*)2-GAP-Grb2-Sos]+[ERK-PP] ? [(EGF-EGFR*)2-GAP-Grb2-Sos-ERK-PP] 127 126 083 019 126 096 011 1 negative_feedback_loop [(EGF-EGFRi*)2-GAP-Grb2-Sos]+[ERKi-PP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos-ERKi-PP] 128 126 059 035 126 097 011 1 negative_feedback_loop [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos]+[ERK-PP] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-ERK-PP] 129 126 083 066 126 098 011 1 negative_feedback_loop [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos]+[ERKi-PP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-ERKi-PP] 130 126 059 024 126 101 011 1 negative_feedback_loop [Sos]+[ERK-PP] ? [Sos-ERK-PP] 131 126 083 024 126 102 011 1 negative_feedback_loop [Sos]+[ERKi-PP] ? [Sos-ERKi-PP] 143 127 059 099 127 095 011 1 negative_feedback_loop [(EGF-EGFR*)2-GAP-Grb2-Sos-ERK-PP] ? [(EGF-EGFR*)2-GAP-Grb2-Sos]deg+[ERK-PP] 144 127 059 099 127 097 011 1 negative_feedback_loop [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-ERK-PP] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos]deg+[ERK-PP] 145 127 059 103 127 101 011 1 negative_feedback_loop [Sos-ERK-PP] ? [Sosi]+[ERK-PP] 146 127 083 100 127 096 011 1 negative_feedback_loop [(EGF-EGFRi*)2-GAP-Grb2-Sos-ERKi-PP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos]deg+[ERKi-PP] 147 127 083 100 127 098 011 1 negative_feedback_loop [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-ERKi-PP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos]deg+[ERKi-PP] 148 127 083 103 127 102 011 1 negative_feedback_loop [Sos-ERK-PPi] ? [Sosi]+[ERK-PPi] 004 004 023 012 004 007 012 1 internalization [(EGF-EGFR*)2-GAP-Grb2]+[Prot] ? [(EGF-EGFR*)2-GAP-Grb2-Prot] 005 005 018 009 005 007 012 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Prot] ? [ (EGF-EGFRi*)2-GAP-Grb2]+[Proti] 006 006 002 000 006 006 012 1 internalization [EGFR] ? [EGFRi] 007 006 005 000 006 008 012 1 internalization [(EGF-EGFR*)2] ? [(EGF-EGFRi*)2] 009 006 023 000 006 018 012 1 internalization [(EGF-EGFR*)2-GAP] ? [(EGF-EGFRi*)2-GAP] 015 015 009 000 015 012 012 1 internalization [Proti] ? [Prot] 102 006 015 000 006 017 012 1 internalization [(EGF-EGFR*)2-GAP] ? [(EGF-EGFRi*)2-GAP] 103 006 032 000 006 063 012 1 internalization [(EGF-EGFR*)2-GAP-Shc] ? [(EGF-EGFRi*)2-GAP-Shc] 104 006 033 000 006 064 012 1 internalization [(EGF-EGFR*)2-GAP-Shc*] ? [(EGF-EGFRi*)2-GAP-Shc*] 105 006 025 000 006 019 012 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos] 106 004 025 012 004 088 012 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos]+[Prot] ?[(EGF-EGFR*)2-GAP-Grb2-Sos-Prot] 107 005 009 019 005 088 012 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Prot] ? [ (EGF-EGFRi*)2-GAP-Grb2-Sos]+[Proti] 108 006 027 000 006 020 012 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP] 109 004 027 012 004 089 012 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP]+[Prot] ?[(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP-Prot] 110 005 009 020 005 089 012 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP-Prot] ? [ (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP]+[Proti] 111 006 029 000 006 021 012 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP] 112 004 029 012 004 090 012 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP]+[Prot] ?[(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP-Prot] 113 005 009 021 005 090 012 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP-Prot] ? [ (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP]+[Proti] 114 006 034 000 006 065 012 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2] 115 004 034 012 004 091 012 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2]+[Prot] ?[(EGF-EGFR*)2-GAP-Shc*-Grb2-Prot] 116 005 009 065 005 091 012 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Prot] ? [ (EGF-EGFRi*)2-GAP-Shc*-Grb2]+[Proti] 117 006 035 000 006 066 012 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] 118 004 035 012 004 092 012 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos]+[Prot] ?[(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Prot] 119 005 009 066 005 092 012 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Prot] ? [ (EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos]+[Proti] 120 006 036 000 006 067 012 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] 121 004 036 012 004 093 012 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GDP]+[Prot] ?[(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GDP-Prot] 122 005 009 067 005 093 012 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GDP-Prot] ? [ (EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GDP]+[Proti] 123 006 037 000 006 068 012 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] 124 004 037 012 004 094 012 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GTP]+[Prot] ?[(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GTP-Prot] 125 005 068 009 005 094 012 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GTP-Prot] ? [ (EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GTP]+[Proti] 060 060 006 000 060 086 013 1 degradation [EGFRi] ? [EGFRideg] 061 061 016 000 061 013 013 1 degradation [EGFi]? [EGFideg] 062 060 008 000 060 087 013 1 degradation [(EGF-EGFRi*)2] ? [(EGF-EGFRi*)2deg] 132 060 017 000 060 087 013 1 degradation [(EGF-EGFRi*)2-GAP] ? [(EGF-EGFRi*)2deg] 133 060 018 000 060 087 013 1 degradation [(EGF-EGFRi*)2-GAP-Grb2] ? [(EGF-EGFRi*)2deg] 134 060 019 000 060 087 013 1 degradation [(EGF-EGFRi*)2-GAP-Grb2-Sos] ? [(EGF-EGFRi*)2deg] 135 060 020 000 060 087 013 1 degradation [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP] ? [(EGF-EGFRi*)2deg] 136 060 021 000 060 087 013 1 degradation [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP] ? [(EGF-EGFRi*)2deg] 137 060 063 000 060 087 013 1 degradation [(EGF-EGFRi*)2-GAP-Shc] ? [(EGF-EGFRi*)2deg] 138 060 064 000 060 087 013 1 degradation [(EGF-EGFRi*)2-GAP-Shc*] ? [(EGF-EGFRi*)2deg] 139 060 065 000 060 087 013 1 degradation [(EGF-EGFRi*)2-GAP-Shc*-Grb2] ? [(EGF-EGFRi*)2deg] 140 060 066 000 060 087 013 1 degradation [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] ? [(EGF-EGFRi*)2deg] 141 060 067 000 060 087 013 1 degradation [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] ? [(EGF-EGFRi*)2deg] 142 060 068 000 060 087 013 1 degradation [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] ? [(EGF-EGFRi*)2deg]HornbergRxnSynth.txt0000444000076500007650000003623110653731147015335 0ustar apgarapgar00000000000000Num Fwd R1 R2 Rev P Step Include ProcessDescription RxnDescription 200 214 14 0 200 0 13 1 degradation [GAP] Prod Deg 201 222 22 0 200 0 13 1 degradation [Grb2] Prod Deg 202 224 24 0 200 0 13 1 degradation [Sos] Prod Deg 203 226 26 0 200 0 13 1 degradation [Ras-GDP] Prod Deg 204 231 31 0 200 0 13 1 degradation [Shc] Prod Deg 205 230 30 0 200 0 13 1 degradation [Grb2-SOS] Prod Deg 60 60 6 0 60 0 13 1 degradation [EGFRi] ? [EGFRideg] 61 61 16 0 61 13 13 1 degradation [EGFi]? [EGFideg] 62 60 8 0 60 0 13 1 degradation [(EGF-EGFRi*)2] ? [(EGF-EGFRi*)2deg] 132 60 17 0 60 0 13 1 degradation [(EGF-EGFRi*)2-GAP] ? [(EGF-EGFRi*)2deg] 133 60 18 0 60 0 13 1 degradation [(EGF-EGFRi*)2-GAP-Grb2] ? [(EGF-EGFRi*)2deg] 134 60 19 0 60 0 13 1 degradation [(EGF-EGFRi*)2-GAP-Grb2-Sos] ? [(EGF-EGFRi*)2deg] 135 60 20 0 60 0 13 1 degradation [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP] ? [(EGF-EGFRi*)2deg] 136 60 21 0 60 0 13 1 degradation [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP] ? [(EGF-EGFRi*)2deg] 137 60 63 0 60 0 13 1 degradation [(EGF-EGFRi*)2-GAP-Shc] ? [(EGF-EGFRi*)2deg] 138 60 64 0 60 0 13 1 degradation [(EGF-EGFRi*)2-GAP-Shc*] ? [(EGF-EGFRi*)2deg] 139 60 65 0 60 0 13 1 degradation [(EGF-EGFRi*)2-GAP-Shc*-Grb2] ? [(EGF-EGFRi*)2deg] 140 60 66 0 60 0 13 1 degradation [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] ? [(EGF-EGFRi*)2deg] 141 60 67 0 60 0 13 1 degradation [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] ? [(EGF-EGFRi*)2deg] 142 60 68 0 60 0 13 1 degradation [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] ? [(EGF-EGFRi*)2deg] 56 56 59 60 56 61 10 1 ERK_dephosphorylation [ERK-PP]+[Phosphatase3] ? [ERK-PP-Phosphatase3] 57 57 57 60 57 61 10 1 ERK_dephosphorylation [ERK-PP-Phosphatase3] ? [ERK-P]+[Phosphatase3] 58 58 60 57 58 62 10 1 ERK_dephosphorylation [ERK-P] + [Phosphatase3] ? [ERK-P-Phosphatase3] 59 57 55 60 57 62 10 1 ERK_dephosphorylation [ERK-P-Phosphatase3] ? [ERK]+[Phosphatase3] 98 56 83 60 56 84 10 1 ERK_dephosphorylation [ERKi-PP]+[Phosphatase3] ? [ERKi-PP-Phosphatase3] 99 57 81 60 57 84 10 1 ERK_dephosphorylation [ERKi-PP-Phosphatase3] ? [ERKi-P]+[Phosphatase3] 100 58 60 81 58 85 10 1 ERK_dephosphorylation [ERKi-P] + [Phosphatase3] ? [ERKi-P-Phosphatase3] 101 57 55 60 57 85 10 1 ERK_dephosphorylation [ERKi-P-Phosphatase3] ? [ERK]+[Phosphatase3] 52 52 55 51 44 56 9 1 ERK_phosphorylation [ERK]+[MEK-PP] ? [ERK-MEK-PP] 53 53 51 57 53 56 9 1 ERK_phosphorylation [ERK-MEK-PP] ? [ERK-P]+[MEK-PP] 54 52 51 57 44 58 9 1 ERK_phosphorylation [ERK-P]+[MEK-PP] ? [ERK-P-MEK-PP] 55 55 59 51 55 58 9 1 ERK_phosphorylation [ERK-P-MEK-PP] ? [ERK-PP]+[MEK-PP] 94 52 55 77 44 80 9 1 ERK_phosphorylation [ERK]+[MEKi-PP] ? [ERK-MEKi-PP] 95 53 81 77 53 80 9 1 ERK_phosphorylation [ERK-MEKi-PP] ? [ERKi-P]+[MEKi-PP] 96 52 77 81 44 82 9 1 ERK_phosphorylation [ERKi-P]+[MEKi-PP] ? [ERKi-P-MEKi-PP] 97 55 83 77 55 82 9 1 ERK_phosphorylation [ERKi-P-MEKi-PP] ? [ERKi-PP]+[MEKi-PP] 4 4 23 12 4 7 12 1 internalization [(EGF-EGFR*)2-GAP-Grb2]+[Prot] ? [(EGF-EGFR*)2-GAP-Grb2-Prot] 5 5 18 9 5 7 12 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Prot] ? [ (EGF-EGFRi*)2-GAP-Grb2]+[Proti] 6 6 2 0 6 6 12 1 internalization [EGFR] ? [EGFRi] 7 6 5 0 6 8 12 1 internalization [(EGF-EGFR*)2] ? [(EGF-EGFRi*)2] 9 6 23 0 6 18 12 1 internalization [(EGF-EGFR*)2-GAP] ? [(EGF-EGFRi*)2-GAP] 15 15 9 0 15 12 12 1 internalization [Proti] ? [Prot] 102 6 15 0 6 17 12 1 internalization [(EGF-EGFR*)2-GAP] ? [(EGF-EGFRi*)2-GAP] 103 6 32 0 6 63 12 1 internalization [(EGF-EGFR*)2-GAP-Shc] ? [(EGF-EGFRi*)2-GAP-Shc] 104 6 33 0 6 64 12 1 internalization [(EGF-EGFR*)2-GAP-Shc*] ? [(EGF-EGFRi*)2-GAP-Shc*] 105 6 25 0 6 19 12 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos] 106 4 25 12 4 88 12 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos]+[Prot] ?[(EGF-EGFR*)2-GAP-Grb2-Sos-Prot] 107 5 9 19 5 88 12 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Prot] ? [ (EGF-EGFRi*)2-GAP-Grb2-Sos]+[Proti] 108 6 27 0 6 20 12 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP] 109 4 27 12 4 89 12 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP]+[Prot] ?[(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP-Prot] 110 5 9 20 5 89 12 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP-Prot] ? [ (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP]+[Proti] 111 6 29 0 6 21 12 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP] 112 4 29 12 4 90 12 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP]+[Prot] ?[(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP-Prot] 113 5 9 21 5 90 12 1 internalization [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP-Prot] ? [ (EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP]+[Proti] 114 6 34 0 6 65 12 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2] 115 4 34 12 4 91 12 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2]+[Prot] ?[(EGF-EGFR*)2-GAP-Shc*-Grb2-Prot] 116 5 9 65 5 91 12 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Prot] ? [ (EGF-EGFRi*)2-GAP-Shc*-Grb2]+[Proti] 117 6 35 0 6 66 12 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] 118 4 35 12 4 92 12 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos]+[Prot] ?[(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Prot] 119 5 9 66 5 92 12 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Prot] ? [ (EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos]+[Proti] 120 6 36 0 6 67 12 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] 121 4 36 12 4 93 12 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GDP]+[Prot] ?[(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GDP-Prot] 122 5 9 67 5 93 12 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GDP-Prot] ? [ (EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GDP]+[Proti] 123 6 37 0 6 68 12 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] 124 4 37 12 4 94 12 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GTP]+[Prot] ?[(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GTP-Prot] 125 5 68 9 5 94 12 1 internalization [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GTP-Prot] ? [ (EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GTP]+[Proti] 48 48 51 53 48 52 8 1 MEK_dephosphorylation [MEK-PP]+[Phosphatase2] ? [MEK-PP-Phosphatase2] 49 49 49 53 49 52 8 1 MEK_dephosphorylation [MEK-PP-Phosphatase2] ? [MEK-P] + [Phosphatase2] 50 50 53 49 50 54 8 1 MEK_dephosphorylation [MEK-P]+[Phosphatase2] ? [MEK-P-Phosphatase2] 51 49 47 53 49 54 8 1 MEK_dephosphorylation [MEK-P-Phosphatase2] ? [MEK]+[Phosphatase2] 90 48 77 53 48 78 8 1 MEK_dephosphorylation [MEKi-PP]+[Phosphatase2] ? [MEKi-PP-Phosphatase2] 91 49 75 53 49 78 8 1 MEK_dephosphorylation [MEKi-PP-Phosphatase2] ? [MEKi-P] + [Phosphatase2] 92 50 53 75 50 79 8 1 MEK_dephosphorylation [MEKi-P]+[Phosphatase2] ? [MEKi-P-Phosphatase2] 93 49 47 53 49 79 8 1 MEK_dephosphorylation [MEKi-P-Phosphatase2] ? [MEK]+[Phosphatase2] 126 126 59 25 126 95 11 1 negative_feedback_loop [(EGF-EGFR*)2-GAP-Grb2-Sos]+[ERK-PP] ? [(EGF-EGFR*)2-GAP-Grb2-Sos-ERK-PP] 127 126 83 19 126 96 11 1 negative_feedback_loop [(EGF-EGFRi*)2-GAP-Grb2-Sos]+[ERKi-PP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos-ERKi-PP] 128 126 59 35 126 97 11 1 negative_feedback_loop [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos]+[ERK-PP] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-ERK-PP] 129 126 83 66 126 98 11 1 negative_feedback_loop [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos]+[ERKi-PP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-ERKi-PP] 130 126 59 24 126 101 11 1 negative_feedback_loop [Sos]+[ERK-PP] ? [Sos-ERK-PP] 131 126 83 24 126 102 11 1 negative_feedback_loop [Sos]+[ERKi-PP] ? [Sos-ERKi-PP] 143 127 59 99 127 95 11 1 negative_feedback_loop [(EGF-EGFR*)2-GAP-Grb2-Sos-ERK-PP] ? [(EGF-EGFR*)2-GAP-Grb2-Sos]deg+[ERK-PP] 144 127 59 99 127 97 11 1 negative_feedback_loop [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-ERK-PP] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos]deg+[ERK-PP] 145 127 59 103 127 101 11 1 negative_feedback_loop [Sos-ERK-PP] ? [Sosi]+[ERK-PP] 146 127 83 100 127 96 11 1 negative_feedback_loop [(EGF-EGFRi*)2-GAP-Grb2-Sos-ERKi-PP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos]deg+[ERKi-PP] 147 127 83 100 127 98 11 1 negative_feedback_loop [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-ERKi-PP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos]deg+[ERKi-PP] 148 127 83 103 127 102 11 1 negative_feedback_loop [Sos-ERK-PPi] ? [Sosi]+[ERK-PPi] 42 42 44 45 42 46 7 1 Raf_dephosphorylation [Raf*]+[Phosphatase1] ? [Raf*-Phosphatase1] 43 43 41 44 43 46 7 1 Raf_dephosphorylation [Raf*-Phosphatase1] ? [Raf]+[Phosphatase1] 84 42 44 72 42 73 7 1 Raf_dephosphorylation [Rafi*]+[Phosphatase1] ? [Rafi*-Phosphatase1] 85 43 41 44 43 73 7 1 Raf_dephosphorylation [Rafi*-Phosphatase1] ? [Raf]+[Phosphatase1] 44 44 47 45 52 48 6 1 Raf_phosphorylates_MEK [MEK] + [Raf*] ? [MEK-Raf*] 45 45 49 45 45 48 6 1 Raf_phosphorylates_MEK [MEK-Raf*] ? [MEK-P] +[Raf*] 46 44 49 45 52 50 6 1 Raf_phosphorylates_MEK [MEK-P]+[Raf*] ? [MEK-P-Raf*] 47 47 51 45 47 50 6 1 Raf_phosphorylates_MEK [MEK-P-Raf*] ? [MEK-PP] + [Raf*] 86 44 47 72 52 74 6 1 Raf_phosphorylates_MEK [MEK] + [Rafi*] ? [MEK-Rafi*] 87 45 75 72 45 74 6 1 Raf_phosphorylates_MEK [MEK-Rafi*] ? [MEKi-P] +[Rafi*] 88 44 72 75 52 76 6 1 Raf_phosphorylates_MEK [MEKi-P]+[Rafi*] ? [MEK-P-Rafi*] 89 47 72 77 47 76 6 1 Raf_phosphorylates_MEK [MEK-P-Rafi*] ? [MEKi-PP] + [Rafi*] 28 28 28 41 28 42 4 1 Ras_activates_Raf [Raf]+[Ras-GTP] ? [Raf-Ras-GTP] 29 29 43 45 29 42 4 1 Ras_activates_Raf [Raf-Ras-GTP] ? [Raf*]+[Ras-GTP*] 75 28 69 41 28 70 4 1 Ras_activates_Raf [Raf]+[Ras-GTPi] ? [Raf-Ras-GTPi] 76 29 71 72 29 70 4 1 Ras_activates_Raf [Raf-Ras-GTPi] ? [Rafi*]+[Ras-GTPi*] 18 18 26 25 18 27 3 1 Ras_activation [(EGF-EGFR*)2-GAP-Grb2-Sos]+[Ras-GDP] ? [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP] 19 19 28 25 19 27 3 1 Ras_activation [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP] ? [(EGF-EGFR*)2-GAP-Grb2-Sos]+[Ras-GTP] 26 18 26 35 18 36 3 1 Ras_activation [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos]+[Ras-GDP] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] 27 19 35 28 19 36 3 1 Ras_activation [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos] + [Ras-GTP] 65 18 26 19 18 20 3 1 Ras_activation [(EGF-EGFRi*)2-GAP-Grb2-Sos]+[Ras-GDP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP] 66 19 69 19 19 20 3 1 Ras_activation [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos]+[Ras-GTPi] 73 18 26 66 18 67 3 1 Ras_activation [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos]+[Ras-GDP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] 74 19 66 69 19 67 3 1 Ras_activation [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GDP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] + [Ras-GTPi] 14 8 8 14 8 17 5 1 Ras_inactivation [(EGF-EGFRi*)2]+ [GAP] ? [(EGF-EGFRi*)2-GAP] 20 20 25 43 20 29 5 1 Ras_inactivation [Ras-GTP*]+[(EGF-EGFR*)2-GAP-Grb2-Sos] ? [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP] 21 21 25 26 21 29 5 1 Ras_inactivation [(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP] ? [(EGF-EGFR*)2-GAP-Grb2-Sos]+[Ras-GDP] 30 20 35 43 20 37 5 1 Ras_inactivation [Ras-GTP*]+[(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] 31 21 35 26 21 37 5 1 Ras_inactivation [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos]+[Ras-GDP] 67 20 71 19 20 21 5 1 Ras_inactivation [Ras-GTPi*]+[(EGF-EGFRi*)2-GAP-Grb2-Sos] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTPi] 68 21 19 26 21 21 5 1 Ras_inactivation [(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos]+[Ras-GDP] 77 20 71 66 20 68 5 1 Ras_inactivation [Ras-GTPi*]+[(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] 78 21 66 26 21 68 5 1 Ras_inactivation [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos-Ras-GTP] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos]+[Ras-GDP] 1 1 1 2 1 3 1 1 receptor_activation [EGFR]+[EGF] ? [EGF-EGFR] 2 2 3 3 2 4 1 1 receptor_activation [EGF-EGFR]+[EGF-EGFR] ? [(EGF-EGFR)2] 3 3 4 0 3 5 1 1 receptor_activation [(EGF-EGFR)2] ? [(EGF-EGFR*)2] 10 10 6 16 10 10 1 1 receptor_activation [EGFRi]+[EGFi] ? [EGF-EGFRi] 11 2 10 10 2 11 1 1 receptor_activation [EGF-EGFRi]+[EGF-EGFRi] ? [(EGF-EGFRi)2] 12 3 11 0 3 8 1 1 receptor_activation [(EGF-EGFRi)2] ? [(EGF-EGFRi*)2] 13 13 0 0 13 2 1 1 receptor_activation ? [EGFR] 8 8 5 14 8 15 2 1 recruitment [(EGF-EGFR*)2]+[GAP] ? [(EGF-EGFR*)2-GAP] 16 16 22 15 63 23 2 1 recruitment [(EGF-EGFR*)2-GAP]+[Grb2] ? [(EGF-EGFR*)2-GAP-Grb2] 17 17 24 23 17 25 2 1 recruitment [(EGF-EGFR*)2-GAP-Grb2]+[Sos] ? [(EGF-EGFR*)2-GAP-Grb2-Sos] 22 22 31 15 22 32 2 1 recruitment [(EGF-EGFR*)2-GAP]+[Shc] ? [(EGF-EGFR*)2-GAP-Shc] 23 23 32 0 23 33 2 1 recruitment [(EGF-EGFR*)2-GAP-Shc] ? [(EGF-EGFR*)2-GAP-Shc*] 24 16 22 33 24 34 2 1 recruitment [(EGF-EGFR*)2-GAP-Shc*]+[Grb2] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2] 25 25 24 34 25 35 2 1 recruitment [(EGF-EGFR*)2-GAP-Shc*-Grb2]+[Sos] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos] 32 32 15 38 32 35 2 1 recruitment [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos] ? [(EGF-EGFR*)2-GAP]+[Shc*-Grb2-Sos] 33 33 40 30 33 38 2 1 recruitment [Shc*-Grb2-Sos] ? [Grb2-Sos]+[Shc*] 34 34 15 30 34 25 2 1 recruitment [(EGF-EGFR*)2-GAP-Grb2-Sos] ? [(EGF-EGFR*)2-GAP]+[Grb2-Sos] 35 35 24 22 35 30 2 1 recruitment [Grb2-Sos] ? [Grb2] +[Sos] 36 36 40 0 36 31 2 1 recruitment [Shc*] ? [Shc] 37 37 15 40 37 33 2 1 recruitment [(EGF-EGFR*)2-GAP-Shc*] ? [(EGF-EGFR*)2-GAP]+[Shc*] 38 16 22 40 24 39 2 1 recruitment [Shc*]+[Grb2] ? [Shc*-Grb2] 39 37 15 39 37 34 2 1 recruitment [(EGF-EGFR*)2-GAP-Shc*-Grb2] ? [(EGF-EGFR*)2-GAP]+[Shc*-Grb2] 40 40 24 39 40 38 2 1 recruitment [Shc*-Grb2]+[Sos] ? [Shc*-Grb2-Sos] 41 41 30 33 41 35 2 1 recruitment [(EGF-EGFR*)2-GAP-Shc*] + [Grb2-Sos] ? [(EGF-EGFR*)2-GAP-Shc*-Grb2-Sos] 63 16 17 22 63 18 2 1 recruitment [(EGF-EGFRi*)2-GAP]+[Grb2] ? [(EGF-EGFRi*)2-GAP-Grb2] 64 17 24 18 17 19 2 1 recruitment [(EGF-EGFRi*)2-GAP-Grb2]+[Sos] ? [(EGF-EGFRi*)2-GAP-Grb2-Sos] 69 22 31 17 22 63 2 1 recruitment [(EGF-EGFRi*)2-GAP]+[Shc] ? [(EGF-EGFRi*)2-GAP-Shc] 70 23 63 0 23 64 2 1 recruitment [(EGF-EGFR*)2-GAP-Shc] ? [(EGF-EGFR*)2-GAP-Shc*] 71 16 22 64 24 65 2 1 recruitment [(EGF-EGFRi*)2-GAP-Shc*]+[Grb2] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2] 72 25 24 65 25 66 2 1 recruitment [(EGF-EGFRi*)2-GAP-Shc*-Grb2]+[Sos] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] 79 32 17 38 32 66 2 1 recruitment [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] ? [(EGF-EGFRi*)2-GAP]+[Shc-Grb2-Sos] 80 34 17 30 34 19 2 1 recruitment [(EGF-EGFRi*)2-GAP-Grb2-Sos] ? [(EGF-EGFRi*)2-GAP]+[Grb2-Sos] 81 37 17 40 37 64 2 1 recruitment [(EGF-EGFRi*)2-GAP-Shc*] ? [(EGF-EGFRi*)2-GAP]+[Shc*] 82 37 17 39 37 65 2 1 recruitment [(EGF-EGFRi*)2-GAP-Shc*-Grb2] ? [(EGF-EGFRi*)2-GAP]+[Shc*-Grb2] 83 41 30 64 41 66 2 1 recruitment [(EGF-EGFRi*)2-GAP-Shc*] + [Grb2-Sos] ? [(EGF-EGFRi*)2-GAP-Shc*-Grb2-Sos] 1000 300 14 28 20 104 5 1 Ras_inactivation [GAP-Ras-GTP] ? [GAP]+[Ras-GTP] 1001 0 14 26 21 104 5 1 Ras_inactivation [GAP-Ras-GTP] ? [GAP]+[Ras-GDP] 1002 300 14 69 20 105 5 1 Ras_inactivation [GAP-Ras-GTPi] ? [GAP]+[Ras-GTPi] 1003 0 14 26 21 105 5 1 Ras_inactivation [GAP-Ras-GTPi] ? [GAP]+[Ras-GDP] 1004 300 14 43 20 106 5 1 Ras_inactivation [GAP-Ras-GTP*] ? [GAP]+[Ras-GTP*] 1005 0 14 26 21 106 5 1 Ras_inactivation [GAP-Ras-GTP*] ? [GAP]+[Ras-GDP] 1004 300 14 71 20 107 5 1 Ras_inactivation [GAP-Ras-GTPi*] ? [GAP]+[Ras-GTPi*] 1005 0 14 26 21 107 5 1 Ras_inactivation [GAP-Ras-GTPi*] ? [GAP]+[Ras-GDP] 1006 300 103 26 0 24 5 1 SOSi Turnover [SOSi] ? [SOS]