206
MSRA
P - Translation
methionine metabolic process
TAS
response to oxidative stress
TAS
protein modification
TAS
protein-methionine-S-oxide reductase activity
TAS
575
MCM2
D - Genome Maintenance
nucleus
null
nucleoplasm
EXP
chromatin
TAS
DNA replication
TAS
cell cycle
null
DNA replication initiation
IEA
regulation of transcription
IEA
transcription
IEA
protein binding
IPI
zinc ion binding
IEA
DNA binding
null
ATP binding
IEA
221
BUB1B
D - Genome Maintenance
cytoplasm
IDA
outer kinetochore of condensed chromosome
IDA
microtubule organizing center
IEA
anaphase-promoting complex
TAS
kinetochore
null
spindle midzone
NAS
cytosol
EXP
mitotic checkpoint
null
cell cycle
NAS
mitosis
null
cell proliferation
null
phosphoinositide-mediated signaling
NAS
apoptosis
IEA
protein amino acid phosphorylation
IEA
negative regulation of ubiquitin ligase activity during mitotic cell cycle
EXP
spindle organization and biogenesis
NAS
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
EXP
cell division
IEA
protein binding
IPI
protein kinase activity
null
protein serine/threonine kinase activity
IEA
ATP binding
IEA
925
ATM
D - Genome Maintenance
cytoplasmic membrane-bound vesicle
IEA
nucleoplasm
EXP
mitotic spindle checkpoint
IMP
pre-B cell allelic exclusion
ISS
G2/M transition DNA damage checkpoint
IMP
DNA damage induced protein phosphorylation
IDA
senescence (sensu Magnoliophyta)
IEP
signal transduction
null
protein amino acid autophosphorylation
IDA
DNA repair
null
response to ionizing radiation
IDA
positive regulation of DNA damage response, signal transduction by p53 class mediator
IMP
cell cycle arrest
IMP
regulation of progression through cell cycle
TAS
meiotic recombination
TAS
protein N-terminus binding
IDA
protein serine/threonine kinase activity
IDA
DNA-dependent protein kinase activity
IDA
phosphatidylinositol 3-kinase activity
IMP
protein dimerization activity
IDA
protein complex binding
IDA
ATP binding
IEA
DNA binding
IEA
1380
MDM2
D - Genome Maintenance
endocytic vesicle membrane
EXP
protein complex
IDA
plasma membrane
EXP
nucleolus
IDA
nucleoplasm
IDA
insoluble fraction
IDA
cytosol
EXP
positive regulation of cell proliferation
TAS
protein ubiquitination
IDA
negative regulation of cell proliferation
null
regulation of protein catabolic process
IDA
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
IDA
negative regulation of transcription from RNA polymerase II promoter
IDA
establishment of protein localization
IDA
protein destabilization
IDA
protein complex assembly
IDA
protein ubiquitination during ubiquitin-dependent protein catabolic process
IDA
interspecies interaction between organisms
IEA
negative regulation of DNA damage response, signal transduction by p53 class mediator
IDA
regulation of progression through cell cycle
TAS
p53 binding
IPI
ubiquitin-protein ligase activity
IDA
negative regulator of basal transcription activity
IDA
zinc ion binding
IDA
enzyme binding
IPI
identical protein binding
IPI
295
GATA2
T - Transcription
nucleus
null
phagocytosis
IEA
positive regulation of phagocytosis
ISS
transcription from RNA polymerase II promoter
null
transcription
IEA
sequence-specific DNA binding
IEA
transcription factor activity
null
zinc ion binding
IEA
transcription factor binding
IPI
649
SMARCA4
D - Genome Maintenance
SWI/SNF complex
IDA
nucleoplasm
null
nucleus
TAS
positive regulation of transcription factor activity
IDA
regulation of transcription from RNA polymerase II promoter
null
chromatin remodeling
IDA
negative regulation of S phase of mitotic cell cycle
TAS
transcription
IEA
protein binding
IPI
p53 binding
IPI
protein N-terminus binding
IPI
transcription factor activity
null
transcriptional activator activity
IMP
transcription coactivator activity
null
helicase activity
null
ATP binding
IEA
DNA binding
IEA
identical protein binding
IPI
DNA-dependent ATPase activity
IGI
378
LCK
D - Genome Maintenance
Golgi apparatus
IDA
plasma membrane
NAS
lipid raft
IDA
pericentriolar material
IDA
cytosol
EXP
hemopoiesis
NAS
intracellular signaling cascade
null
release of sequestered calcium ion into cytosol
ISS
caspase activation
IDA
response to drug
IDA
zinc ion homeostasis
IEP
Ras protein signal transduction
null
induction of apoptosis
IMP
positive regulation of T cell receptor signaling pathway
NAS
regulation of lymphocyte activation
NAS
T cell differentiation
IMP
interspecies interaction between organisms
IEA
positive regulation of T cell activation
IDA
protein amino acid phosphorylation
TAS
regulation of progression through cell cycle
NAS
protein kinase binding
IPI
CD8 receptor binding
IPI
protein C-terminus binding
IPI
ATP binding
IEA
glycoprotein binding
IPI
CD4 receptor binding
IPI
ATPase binding
IPI
protein-tyrosine kinase activity
null
protein serine/threonine phosphatase activity
IDA
non-membrane spanning protein tyrosine kinase activity
IEA
SH2 domain binding
IPI
phosphoinositide 3-kinase binding
IPI
255
TCF12
T - Transcription
nucleus
IDA
immune response
TAS
muscle development
TAS
regulation of transcription from RNA polymerase II promoter
TAS
transcription
IEA
protein binding
IPI
transcription factor activity
IDA
RNA polymerase II transcription factor activity
TAS
316
TSC1
D - Genome Maintenance
membrane
IEA
cell cortex
IDA
lamellipodium
IDA
negative regulation of protein biosynthetic process
IMP
negative regulation of TOR signaling pathway
IMP
negative regulation of cell proliferation
IMP
regulation of stress fiber formation
IDA
Rho protein signal transduction
TAS
positive regulation of focal adhesion formation
IDA
rRNA export from nucleus
IMP
cell-matrix adhesion
IMP
regulation of phosphoprotein phosphatase activity
IMP
negative regulation of protein ubiquitination
IDA
cell adhesion
TAS
regulation of progression through cell cycle
NAS
protein N-terminus binding
IPI
chaperone binding
IPI
523
ARNTL
C - Cellular Fate and Organization
transcription factor complex
IPI
signal transduction
IEA
positive regulation of transcription from RNA polymerase II promoter
IGI
circadian rhythm
TAS
transcription
IEA
Hsp90 protein binding
IDA
aryl hydrocarbon receptor binding
IPI
signal transducer activity
IEA
220
ATF1
T - Transcription
regulation of transcription, DNA-dependent
IEA
transcription
IEA
sequence-specific DNA binding
IEA
protein binding
IPI
transcription factor activity
null
protein dimerization activity
IEA
206
TOP3B
D - Genome Maintenance
nucleus
null
DNA unwinding during replication
IEA
DNA topological change
IEA
chromosome organization and biogenesis (sensu Eukaryota)
TAS
protein binding
IPI
DNA topoisomerase activity
TAS
DNA topoisomerase type I activity
IEA
ATP binding
IEA
DNA binding
null
682
CDKN1A
D - Genome Maintenance
cyclin-dependent protein kinase holoenzyme complex
IDA
nucleus
null
nucleoplasm
EXP
cytosol
EXP
negative regulation of cell growth
IDA
negative regulation of cell proliferation
null
Ras protein signal transduction
IEP
regulation of cyclin-dependent protein kinase activity
null
positive regulation of fibroblast proliferation
IMP
senescence (sensu Magnoliophyta)
IDA
negative regulation of phosphorylation
IDA
G1/S transition of mitotic cell cycle
IDA
G2/M transition of mitotic cell cycle
IMP
cellular response to extracellular stimulus
IMP
cell cycle arrest
null
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
IDA
induction of apoptosis by intracellular signals
TAS
protein binding
IPI
cyclin-dependent protein kinase inhibitor activity
null
zinc ion binding
IEA
206
FCGR2B
C - Cellular Fate and Organization
plasma membrane
NAS
integral to membrane
IEA
signal transduction
null
immune response
null
interspecies interaction between organisms
IEA
protein binding
IPI
internalization receptor activity
null
IgG binding
IEA
receptor activity
IEA
318
GHR
C - Cellular Fate and Organization
cell surface
IDA
integral to plasma membrane
null
extracellular space
IDA
tyrosine phosphorylation of JAK2 protein
ISS
isoleucine metabolic process
ISS
taurine metabolic process
ISS
allantoin metabolic process
ISS
positive regulation of tyrosine phosphorylation of Stat5 protein
ISS
receptor internalization
IDA
activation of MAPK activity
ISS
citrate metabolic process
ISS
succinate metabolic process
ISS
2-oxoglutarate metabolic process
ISS
growth pattern
null
fatty acid metabolic process
ISS
multicellular organismal metabolic process
IMP
valine metabolic process
ISS
positive regulation of body size
IMP
response to estradiol stimulus
IDA
positive regulation of tyrosine phosphorylation of Stat3 protein
ISS
oxaloacetate metabolic process
ISS
response to cycloheximide
IDA
creatinine metabolic process
ISS
endocytosis
IEA
skeletal development
null
creatine metabolic process
ISS
insulin-like growth factor receptor signaling pathway
IMP
growth
TAS
protein binding
IPI
growth factor binding
IPI
protein kinase binding
ISS
growth hormone receptor activity
TAS
peptide hormone binding
IPI
protein homodimerization activity
IDA
2362
CTNNB1
D - Genome Maintenance
centrosome
IDA
plasma membrane
null
beta-catenin destruction complex
IDA
catenin complex
IDA
nucleus
null
cytoskeleton
null
lateral plasma membrane
IDA
positive regulation of transcription factor activity
TAS
regulation of centriole-centriole cohesion
IDA
cell-cell adhesion
IMP
positive regulation of apoptosis
IDA
negative regulation of cell proliferation
IDA
regulation of angiogenesis
TAS
epithelial to mesenchymal transition
TAS
positive regulation of transcription, DNA-dependent
NAS
androgen receptor signaling pathway
NAS
transcription
IEA
protein binding
IPI
cadherin binding
IPI
alpha-catenin binding
IPI
protein phosphatase binding
IPI
transcription coactivator activity
NAS
androgen receptor binding
NAS
signal transducer activity
NAS
kinase binding
IPI
protein C-terminus binding
IPI
320
SF3B1
T - Transcription
nuclear speck
IEA
spliceosome
NAS
nuclear mRNA splicing, via spliceosome
NAS
protein binding
IPI
pre-mRNA splicing factor activity
null
RNA splicing factor activity, transesterification mechanism
NAS
206
ADCY5
M - Other Metabolism
plasma membrane
EXP
integral to membrane
IEA
hormone-mediated signaling
EXP
cAMP biosynthetic process
IEA
G-protein signaling, adenylate cyclase activating pathway
EXP
G-protein signaling, adenylate cyclase inhibiting pathway
EXP
adenylate cyclase activity
IEA
magnesium ion binding
IEA
ATP binding
IEA
218
FANCD2
D - Genome Maintenance
nucleoplasm
EXP
DNA repair
IEA
protein binding
IPI
276
VHL
D - Genome Maintenance
mitochondrion
NAS
membrane
IEA
endoplasmic reticulum
NAS
nucleus
null
cytosol
null
protein ubiquitination
IMP
negative regulation of cell proliferation
null
positive regulation of cell differentiation
NAS
protein stabilization
NAS
response to stress
NAS
anti-apoptosis
NAS
negative regulation of transcription from RNA polymerase II promoter
null
cell morphogenesis
NAS
positive regulation of transcription
IMP
modification-dependent protein catabolic process
IEA
proteolysis
TAS
regulation of progression through cell cycle
null
transcription factor binding
null
305
MLH1
D - Genome Maintenance
nucleus
IC
mismatch repair
TAS
protein binding
IPI
ATP binding
IEA
206
ARHGAP26
C - Cellular Fate and Organization
cytoplasm
IEA
cytoskeleton
IEA
focal adhesion
IEA
signal transduction
IEA
actin cytoskeleton organization and biogenesis
NAS
filopodium formation
IEA
nervous system development
null
SH3 domain binding
IEA
Rho GTPase activator activity
NAS
cytoskeletal adaptor activity
IEA
206
PLAU
C - Cellular Fate and Organization
plasma membrane
EXP
extracellular region
IEA
signal transduction
null
chemotaxis
TAS
blood coagulation
IEA
proteolysis
null
fibrinolysis
IEA
serine-type endopeptidase activity
IEA
549
XPO1
D - Genome Maintenance
cytoplasm
TAS
Cajal body
IEA
ribonucleoprotein complex
IDA
annulate lamellae
IDA
nucleolus
IEA
kinetochore
IDA
nucleoplasm
TAS
nuclear envelope
TAS
cytosol
EXP
interspecies interaction between organisms
IEA
mRNA transport
IEA
protein binding
IPI
RNA binding
IEA
427
NUP98
D - Genome Maintenance
nuclear membrane
IEA
nuclear pore
IDA
Nup107-160 complex
IDA
nucleoplasm
null
DNA replication
IMP
protein import into nucleus, docking
NAS
interspecies interaction between organisms
IEA
nuclear pore organization and biogenesis
NAS
mRNA transport
IEA
nucleocytoplasmic transport
TAS
protein binding
IPI
transporter activity
TAS
structural constituent of nuclear pore
NAS
318
TERF2
D - Genome Maintenance
chromosome, telomeric region
TAS
Golgi apparatus
IDA
Mre11 complex
IDA
nucleoplasm
EXP
nuclear telomere cap complex
IDA
senescence (sensu Magnoliophyta)
NAS
age-dependent telomere shortening
NAS
cell cycle
IEA
negative regulation of telomere maintenance via semi-conservative replication
NAS
telomere maintenance via telomerase
TAS
telomeric loop formation
IDA
protection from non-homologous end joining at telomere
IMP
regulation of transcription
IEA
protein binding
IPI
double-stranded telomeric DNA binding
ISS
telomeric DNA binding
null
protein C-terminus binding
IPI
single-stranded telomeric DNA binding
IMP
protein homodimerization activity
IPI
943
APC
D - Genome Maintenance
centrosome
IDA
adherens junction
IEA
beta-catenin destruction complex
IDA
kinetochore
IDA
nucleus
IDA
tight junction
IDA
lateral plasma membrane
IDA
cytosol
EXP
mitotic spindle checkpoint
IMP
positive regulation of apoptosis
IMP
positive regulation of cell migration
IMP
regulation of attachment of spindle microtubules to kinetochore
NAS
cytokinesis after mitosis
IMP
negative regulation of cyclin-dependent protein kinase activity
IDA
response to DNA damage stimulus
IDA
signal transduction
null
protein complex assembly
null
negative regulation of microtubule depolymerization
IDA
positive regulation of pseudopodium formation
IMP
cell cycle arrest
IDA
cell adhesion
null
protein kinase regulator activity
IDA
microtubule binding
IDA
gamma-catenin binding
IPI
protein kinase binding
IPI
beta-catenin binding
TAS
635
PML
D - Genome Maintenance
nuclear membrane
IDA
cytoplasm
IDA
PML body
TAS
nucleolus
IDA
nucleoplasm
IDA
nucleus
null
insoluble fraction
IDA
nuclear matrix
IDA
response to hypoxia
IDA
negative regulation of cell growth
IDA
negative regulation of cell proliferation
IMP
DNA damage response, signal transduction resulting in induction of apoptosis
IDA
cell aging
IMP
protein stabilization
IDA
induction of apoptosis
IDA
protein targeting
IDA
transcription
IEA
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
ISS
protein complex assembly
IDA
DNA repair
IDA
PML body organization and biogenesis
IDA
positive regulation of histone deacetylation
IDA
maintenance of protein localization in nucleus
IDA
negative regulation of progression through mitotic cell cycle
IDA
interspecies interaction between organisms
IEA
positive regulation of antiviral response by host
IMP
negative regulation of angiogenesis
IMP
negative regulation of transcription
IDA
cell cycle arrest
IMP
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
ISS
transcriptional repressor activity
IDA
protein binding
IPI
transcription factor activity
null
protein heterodimerization activity
IDA
transcription coactivator activity
ISS
zinc ion binding
IDA
DNA binding
IEA
protein homodimerization activity
IPI
ubiquitin protein ligase binding
IPI
cobalt ion binding
IDA
713
CCND1
D - Genome Maintenance
intracellular
IDA
cyclin-dependent protein kinase holoenzyme complex
IDA
nucleoplasm
EXP
cytosol
EXP
G1/S transition of mitotic cell cycle
null
positive regulation of protein amino acid phosphorylation
IDA
positive regulation of cyclin-dependent protein kinase activity
IDA
G1 DNA damage checkpoint
IDA
cell division
IEA
protein binding
IPI
protein kinase binding
IPI
283
RARA
C - Cellular Fate and Organization
cell surface
IC
nucleus
IEA
regulation of transcription, DNA-dependent
IEA
positive regulation of interleukin-4 production
IDA
positive regulation of interleukin-5 production
IDA
negative regulation of tumor necrosis factor-alpha production
IDA
positive regulation of interleukin-13 production
IDA
transcription
IEA
retinoic acid receptor signaling pathway
IMP
signal transduction
NAS
response to estradiol stimulus
IDA
negative regulation of interferon-gamma production
IDA
positive regulation of T-helper 2 cell differentiation
IDA
estrogen receptor signaling pathway
IDA
protein binding
IPI
sequence-specific DNA binding
IEA
transcription factor activity
NAS
retinoic acid binding
IDA
transcription coactivator activity
null
steroid hormone receptor activity
IEA
zinc ion binding
IEA
retinoic acid receptor activity
TAS
443
CLTC
A - Transport and Sensing
melanosome
IEA
clathrin coat of coated pit
IEA
clathrin coat of trans-Golgi network vesicle
IEA
clathrin coat
NAS
receptor internalization
IMP
post-Golgi vesicle-mediated transport
EXP
intracellular protein transport
NAS
protein binding
IPI
structural molecule activity
null
206
BAP1
C - Cellular Fate and Organization
nucleus
null
ubiquitin-dependent protein catabolic process
IEA
negative regulation of cell proliferation
TAS
protein modification
NAS
protein binding
IPI
peptidase activity
NAS
cysteine-type peptidase activity
IEA
ubiquitin thiolesterase activity
IEA
478
CAV1
C - Cellular Fate and Organization
lipid particle
EXP
basolateral plasma membrane
IDA
perinuclear region
ISS
apical plasma membrane
IDA
plasma membrane
IDA
Golgi membrane
IDA
integral to plasma membrane
null
endoplasmic reticulum
IDA
caveola
NAS
lipid raft
IDA
caveolar membrane
IDA
response to estrogen stimulus
IDA
membrane depolarization
ISS
sequestering of lipid
ISS
T cell costimulation
IDA
regulation of smooth muscle contraction
ISS
cholesterol transport
TAS
regulation of peptidase activity
ISS
inactivation of MAPK activity
ISS
negative regulation of BMP signaling pathway
IDA
negative regulation of MAPKKK cascade
ISS
vesicle organization and biogenesis
IDA
positive regulation of vasoconstriction
ISS
negative regulation of nitric oxide biosynthetic process
ISS
negative regulation of epithelial cell differentiation
ISS
interspecies interaction between organisms
IEA
calcium ion transport
ISS
protein homooligomerization
ISS
maintenance of cellular protein localization
ISS
cellular response to starvation
IEP
cholesterol homeostasis
ISS
response to hypoxia
ISS
cytosolic calcium ion homeostasis
IDA
regulation of fatty acid metabolic process
ISS
response to calcium ion
ISS
positive regulation of metalloenzyme activity
ISS
regulation of blood coagulation
IMP
striated muscle development
ISS
negative regulation of endothelial cell proliferation
ISS
triacylglycerol metabolic process
ISS
vasculogenesis
ISS
nitric-oxide synthase binding
IPI
protease activator activity
ISS
protein binding
IPI
cholesterol binding
TAS
structural molecule activity
IDA
270
FAS
C - Cellular Fate and Organization
death-inducing signaling complex
IDA
soluble fraction
null
extracellular region
IEA
integral to membrane
IEA
cytosol
null
activation of pro-apoptotic gene products
EXP
induction of apoptosis by extracellular signals
EXP
signal transduction
null
immune response
IEA
protein complex assembly
null
regulation of apoptosis
NAS
anti-apoptosis
TAS
induction of apoptosis
null
receptor activity
null
kinase binding
IPI
identical protein binding
IPI
transmembrane receptor activity
IEA
1155
XRCC6
D - Genome Maintenance
transcription factor complex
IDA
membrane fraction
null
nucleus
null
DNA-dependent protein kinase complex
IEA
nuclear telomere cap complex
TAS
telomere maintenance
TAS
provirus integration
EXP
initiation of viral infection
EXP
double-strand break repair via nonhomologous end joining
TAS
positive regulation of transcription, DNA-dependent
IDA
DNA ligation
TAS
protein binding
IPI
double-stranded DNA binding
null
ATP-dependent DNA helicase activity
TAS
transcriptional activator activity
IMP
protein C-terminus binding
IPI
DNA binding
NAS
ATP binding
IEA
284
KDR
C - Cellular Fate and Organization
integral to plasma membrane
null
positive regulation of cell migration
IDA
regulation of cell shape
IDA
interspecies interaction between organisms
IEA
protein amino acid phosphorylation
IEA
angiogenesis
IEA
transmembrane receptor protein tyrosine kinase signaling pathway
null
positive regulation of positive chemotaxis
IDA
protein binding
IPI
growth factor binding
IPI
vascular endothelial growth factor receptor activity
TAS
ATP binding
IEA
220
XPC
D - Genome Maintenance
nucleoplasm
EXP
nucleotide-excision repair
null
nucleotide-excision repair, DNA damage removal
EXP
protein binding
IPI
damaged DNA binding
null
single-stranded DNA binding
null
600
MSH2
D - Genome Maintenance
MutSalpha complex
IDA
MutSbeta complex
IDA
nucleus
null
response to X-ray
ISS
isotype switching
ISS
postreplication repair
IDA
maintenance of DNA repeat elements
IMP
negative regulation of neuron apoptosis
ISS
response to UV-B
ISS
base-excision repair
IDA
B cell differentiation
ISS
positive regulation of helicase activity
IDA
response to magnesium ion
IDA
short patch mismatch repair system
IDA
mismatch repair
null
male gonad development
ISS
negative regulation of DNA recombination
IDA
guanine/thymine mispair binding
IMP
protein C-terminus binding
IPI
ATP binding
IEA
DNA binding
null
protein homodimerization activity
IDA
381
SMARCB1
D - Genome Maintenance
SWI/SNF complex
IDA
nucleolus
IDA
nucleoplasm
null
nucleus
IDA
nuclear chromosome
IEA
retroviral genome replication
IDA
positive regulation of transcription factor activity
IDA
cell cycle
IEA
regulation of transcription from RNA polymerase II promoter
null
interspecies interaction between organisms
IEA
DNA integration
TAS
chromatin remodeling
IEA
transcription
IEA
protein binding
IPI
p53 binding
IPI
753
CBL
C - Cellular Fate and Organization
plasma membrane
IDA
nucleus
IEA
cytosol
EXP
protein ubiquitination
TAS
epidermal growth factor receptor signaling pathway
TAS
modification-dependent protein catabolic process
IEA
positive regulation of receptor mediated endocytosis
TAS
cell surface receptor linked signal transduction
TAS
protein binding
IPI
SH3 domain binding
IPI
ubiquitin-protein ligase activity
TAS
transcription factor activity
null
calcium ion binding
IEA
zinc ion binding
IEA
signal transducer activity
IEA
359
CEBPA
C - Cellular Fate and Organization
nucleus
null
regulation of transcription, DNA-dependent
IEA
transcription from RNA polymerase II promoter
TAS
interspecies interaction between organisms
IEA
cytokine and chemokine mediated signaling pathway
NAS
myeloid cell differentiation
NAS
generation of precursor metabolites and energy
TAS
transcription
null
sequence-specific DNA binding
IEA
RNA polymerase II transcription factor activity, enhancer binding
NAS
protein dimerization activity
IEA
transcription factor binding
IPI
206
CDKN2C
D - Genome Maintenance
cytoplasm
null
nucleus
IDA
negative regulation of phosphorylation
IDA
negative regulation of cell growth
IDA
G1/S transition of mitotic cell cycle
IDA
negative regulation of cell proliferation
null
cell cycle arrest
null
induction of apoptosis
IDA
regulation of cyclin-dependent protein kinase activity
IDA
protein kinase binding
IPI
cyclin-dependent protein kinase inhibitor activity
TAS
247
CDKN2A
D - Genome Maintenance
cytoplasm
IDA
nucleus
IDA
negative regulation of cell growth
IDA
negative regulation of cell proliferation
null
negative regulation of cyclin-dependent protein kinase activity
IDA
inhibition of NF-kappaB transcription factor
IDA
Ras protein signal transduction
IEP
induction of apoptosis
IDA
regulation of cyclin-dependent protein kinase activity
null
negative regulation of phosphorylation
IDA
senescence (sensu Magnoliophyta)
IDA
G1/S transition of mitotic cell cycle
IDA
cell cycle checkpoint
TAS
cell cycle arrest
null
negative regulation of cell-matrix adhesion
IMP
protein binding
IPI
NF-kappaB binding
IDA
protein kinase binding
IPI
cyclin-dependent protein kinase inhibitor activity
null
206
CASP2
C - Cellular Fate and Organization
cytosol
EXP
protein maturation via proteolysis
IDA
induction of apoptosis by extracellular signals
EXP
apoptotic program
TAS
proteolysis
null
apoptosis
NAS
cysteine-type endopeptidase activity
IDA
protein domain specific binding
IPI
enzyme binding
null
caspase activity
NAS
identical protein binding
IPI
1406
IRS1
C - Cellular Fate and Organization
microsome
ISS
cytoplasm
null
insulin receptor complex
ISS
caveola
IDA
nucleus
ISS
insulin receptor signaling pathway
IPI
positive regulation of glycogen biosynthetic process
IMP
negative regulation of insulin receptor signaling pathway
ISS
positive regulation of insulin receptor signaling pathway
ISS
glucose homeostasis
TAS
phosphoinositide 3-kinase cascade
IDA
signal transduction
null
positive regulation of phosphoinositide 3-kinase activity
ISS
positive regulation of glucose import
IMP
positive regulation of fatty acid beta-oxidation
IMP
insulin-like growth factor receptor signaling pathway
IPI
negative regulation of insulin secretion
IDA
protein binding
null
insulin-like growth factor receptor binding
IPI
insulin receptor binding
IPI
protein kinase C binding
ISS
signal transducer activity
null
SH2 domain binding
ISS
transmembrane receptor protein tyrosine kinase docking protein activity
TAS
phosphoinositide 3-kinase binding
IPI
209
TFPT
C - Cellular Fate and Organization
nucleus
TAS
induction of apoptosis
TAS
protein binding
IPI
nuclear localization sequence binding
TAS
0
UCP2
A - Transport and Sensing
mitochondrial inner membrane
NAS
integral to membrane
IEA
transport
NAS
mitochondrial transport
IEA
proton transport
TAS
binding
IEA
217
HNF1A
T - Transcription
cytoplasm
IDA
nucleus
IDA
regulation of transcription from RNA polymerase II promoter
null
glucose homeostasis
IMP
positive regulation of transcription, DNA-dependent
IDA
insulin secretion
IMP
transcription
IEA
protein binding
IPI
transcription factor activity
IDA
protein heterodimerization activity
IDA
RNA polymerase II transcription factor activity
null
protein homodimerization activity
IPI
474
INSR
D - Genome Maintenance
microsome
IDA
plasma membrane
TAS
integral to plasma membrane
null
insulin receptor complex
IMP
caveola
IDA
endosome membrane
EXP
insulin receptor signaling pathway
IDA
positive regulation of protein kinase B signaling cascade
IMP
positive regulation of cell proliferation
IDA
protein heterotetramerization
IDA
generation of precursor metabolites and energy
null
positive regulation of nitric oxide biosynthetic process
IMP
activation of MAPK activity
IMP
protein amino acid autophosphorylation
IMP
positive regulation of glucose import
IDA
activation of protein kinase B
IDA
positive regulation of glycolysis
IMP
transformation of host cell by virus
IMP
positive regulation of cell migration
IMP
positive regulation of glycogen biosynthetic process
IDA
carbohydrate metabolic process
null
positive regulation of DNA replication
IMP
positive regulation of mitosis
IMP
multicellular organismal development
null
peptidyl-tyrosine phosphorylation
IDA
glucose homeostasis
IMP
regulation of embryonic development
IMP
signal transduction
null
heart morphogenesis
IMP
G-protein coupled receptor protein signaling pathway
IDA
positive regulation of developmental growth
IMP
positive regulation of protein amino acid phosphorylation
IDA
protein amino acid phosphorylation
null
positive regulation of MAPKKK cascade
IMP
manganese ion binding
IEA
insulin receptor activity
IDA
insulin-like growth factor receptor binding
IDA
insulin-like growth factor I binding
IPI
insulin-like growth factor II binding
IPI
PTB domain binding
IPI
insulin receptor substrate binding
IPI
GTP binding
IDA
ATP binding
IDA
receptor activity
null
transmembrane receptor protein tyrosine kinase signaling protein activity
TAS
transmembrane receptor protein tyrosine kinase activity
null
insulin binding
IDA
SH2 domain binding
IPI
receptor signaling protein tyrosine kinase activity
null
phosphoinositide 3-kinase binding
IPI
1808
EGFR
C - Cellular Fate and Organization
basolateral plasma membrane
IDA
cytoplasm
IDA
plasma membrane
null
nucleus
IDA
integral to membrane
IEA
extracellular space
NAS
endosome
IDA
positive regulation of epithelial cell proliferation
IDA
calcium-dependent phospholipase A2 activation
TAS
positive regulation of cell migration
IMP
cell proliferation
null
regulation of peptidyl-tyrosine phosphorylation
IMP
protein insertion into membrane
TAS
regulation of nitric-oxide synthase activity
IDA
response to stress
NAS
phospholipase C activation
TAS
positive regulation of nitric oxide biosynthetic process
IDA
cell-cell adhesion
IMP
G1/S-specific positive regulation of cyclin-dependent protein kinase activity
IDA
epidermal growth factor receptor signaling pathway
null
ossification
NAS
positive regulation of MAPK activity
IDA
cell surface receptor linked signal transduction
IDA
positive regulation of phosphorylation
IDA
epidermal growth factor receptor activity
IDA
double-stranded DNA binding
NAS
actin filament binding
IDA
protein heterodimerization activity
IDA
protein phosphatase binding
IPI
MAP/ERK kinase kinase activity
NAS
protein-tyrosine kinase activity
IMP
ATP binding
IEA
receptor signaling protein tyrosine kinase activity
IEA
transmembrane receptor activity
IDA
identical protein binding
IPI
228
NBN
D - Genome Maintenance
Mre11 complex
IDA
Golgi apparatus
IDA
nucleolus
IDA
nucleoplasm
EXP
nucleus
null
nuclear chromosome, telomeric region
IDA
nuclear inclusion body
IDA
mitotic G2 checkpoint
IDA
G1/S transition checkpoint
IDA
DNA damage response, signal transduction by p53 class mediator
TAS
double-strand break repair
null
regulation of DNA replication initiation
TAS
meiosis
IEA
telomere maintenance
IMP
cell cycle checkpoint
null
cell cycle arrest
TAS
DNA duplex unwinding
IMP
DNA damage checkpoint
IDA
positive regulation of protein amino acid autophosphorylation
IDA
damaged DNA binding
null
protein N-terminus binding
IPI
transcription factor binding
IPI
245
RUNX1
C - Cellular Fate and Organization
nucleus
TAS
hemopoiesis
ISS
regulation of transcription, DNA-dependent
null
positive regulation of transcription
IDA
positive regulation of transcription from RNA polymerase II promoter
IDA
positive regulation of granulocyte differentiation
IMP
negative regulation of granulocyte differentiation
IMP
myeloid cell differentiation
IDA
multicellular organismal development
null
positive regulation of angiogenesis
ISS
transcription
IEA
protein binding
IPI
chloride ion binding
IEA
transcription factor activity
TAS
protein heterodimerization activity
IDA
transcriptional activator activity
IDA
calcium ion binding
IDA
ATP binding
null
DNA binding
IDA
protein homodimerization activity
IDA
water binding
IDA
transcription factor binding
IDA
411
FGF23
C - Cellular Fate and Organization
extracellular space
NAS
negative regulation of hormone secretion
ISS
negative regulation of osteoblast differentiation
IDA
fibroblast growth factor receptor signaling pathway
EXP
vitamin D catabolic process
IDA
negative regulation of bone mineralization
IDA
cell differentiation
null
growth factor activity
IEA
1042
IGF1R
D - Genome Maintenance
microsome
IDA
integral to plasma membrane
IC
insulin receptor signaling pathway
null
positive regulation of cell proliferation
null
protein tetramerization
IDA
positive regulation of cell migration
IMP
phosphoinositide-mediated signaling
IDA
positive regulation of DNA replication
IMP
anti-apoptosis
null
phosphoinositide 3-kinase cascade
IC
signal transduction
null
immune response
IMP
protein amino acid autophosphorylation
IDA
insulin-like growth factor receptor signaling pathway
IDA
regulation of progression through cell cycle
null
protein binding
null
manganese ion binding
IEA
insulin receptor binding
IDA
insulin-like growth factor I binding
IPI
insulin receptor substrate binding
IPI
ATP binding
IEA
identical protein binding
IPI
insulin-like growth factor receptor activity
IDA
protein-tyrosine kinase activity
IDA
insulin binding
IPI
phosphoinositide 3-kinase binding
IPI
insulin-like growth factor binding
IDA
425
PPP2R1A
D - Genome Maintenance
mitochondrion
null
membrane
null
microtubule cytoskeleton
NAS
protein phosphatase type 2A complex
TAS
nucleus
null
soluble fraction
null
chromosome, pericentric region
IDA
cytosol
null
RNA splicing
NAS
negative regulation of tyrosine phosphorylation of Stat3 protein
NAS
negative regulation of cell growth
null
response to organic substance
NAS
regulation of Wnt receptor signaling pathway
NAS
ceramide metabolic process
NAS
induction of apoptosis
null
regulation of cell adhesion
NAS
inactivation of MAPK activity
null
chromosome segregation
IDA
protein amino acid dephosphorylation
TAS
protein complex assembly
TAS
second-messenger-mediated signaling
NAS
regulation of cell differentiation
NAS
regulation of transcription
null
regulation of growth
NAS
regulation of progression through cell cycle
null
regulation of DNA replication
NAS
protein binding
null
protein heterodimerization activity
null
protein phosphatase type 2A regulator activity
TAS
antigen binding
IPI
219
WAS
C - Cellular Fate and Organization
actin cytoskeleton
TAS
cytosol
EXP
immune response
IMP
protein complex assembly
null
epidermis development
TAS
blood coagulation
TAS
actin polymerization and/or depolymerization
TAS
defense response
TAS
small GTPase regulator activity
TAS
identical protein binding
IPI
232
PRDX1
C - Cellular Fate and Organization
mitochondrion
IDA
melanosome
IEA
nucleus
IDA
skeletal development
null
cell proliferation
TAS
cell redox homeostasis
IEA
hydrogen peroxide catabolic process
IDA
protein binding
IPI
thioredoxin peroxidase activity
IDA
217
JAK3
C - Cellular Fate and Organization
membrane
IEA
cytoskeleton
IEA
endomembrane system
IEA
protein amino acid phosphorylation
null
peptidyl-tyrosine phosphorylation
IEA
protein kinase cascade
IEA
Janus kinase activity
IEA
protein binding
IPI
protein-tyrosine kinase activity
null
non-membrane spanning protein tyrosine kinase activity
IEA
ATP binding
IEA
210
KL
C - Cellular Fate and Organization
integral to plasma membrane
TAS
membrane fraction
TAS
soluble fraction
TAS
integral to membrane
TAS
extracellular space
TAS
positive regulation of bone mineralization
IMP
fibroblast growth factor receptor signaling pathway
EXP
carbohydrate metabolic process
IEA
aging
IMP
beta-glucuronidase activity
IEA
hormone activity
IEA
cation binding
IEA
fibroblast growth factor binding
IPI
vitamin D binding
IEA
signal transducer activity
TAS
beta-glucosidase activity
TAS
hydrolase activity, hydrolyzing O-glycosyl compounds
null
306
IL2
C - Cellular Fate and Organization
extracellular space
null
positive regulation of cell proliferation
null
positive regulation of cell growth
TAS
positive regulation of B cell proliferation
IDA
cell-cell signaling
null
anti-apoptosis
TAS
positive regulation of activated T cell proliferation
IDA
immune response
null
natural killer cell activation
TAS
T cell differentiation
TAS
negative regulation of B cell apoptosis
IDA
cell adhesion
null
antimicrobial humoral response (sensu Vertebrata)
TAS
apoptosis inhibitor activity
null
kinase activator activity
TAS
interleukin-2 receptor binding
TAS
cytokine activity
IDA
growth factor activity
TAS
287
FOXO1
T - Transcription
cytoplasm
IDA
nucleoplasm
EXP
nucleus
IDA
cytosol
EXP
regulation of transcription from RNA polymerase II promoter
null
positive regulation of transcription from RNA polymerase II promoter
IDA
anti-apoptosis
IDA
transcription
IEA
sequence-specific DNA binding
IDA
protein binding
IPI
transcription factor activity
null
transcriptional activator activity
IDA
230
EPS15
C - Cellular Fate and Organization
coated pit
TAS
plasma membrane
IDA
early endosome membrane
IEA
cytosol
EXP
vesicle organization and biogenesis
TAS
epidermal growth factor receptor signaling pathway
TAS
cell proliferation
null
endocytic recycling
IC
protein transport
IEA
clathrin cage assembly
IDA
protein binding
IPI
SH3 domain binding
IEA
calcium ion binding
IEA
1226
RB1
D - Genome Maintenance
SWI/SNF complex
TAS
PML body
IDA
Rb-E2F complex
TAS
nucleus
null
chromatin
null
negative regulation of cell growth
TAS
G1/S transition checkpoint
TAS
regulation of lipid kinase activity
IDA
Ras protein signal transduction
IEP
negative regulation of transcription from RNA polymerase II promoter
null
negative regulation of transcription factor activity
TAS
negative regulation of S phase of mitotic cell cycle
TAS
transcription
IEA
G1/S-specific transcription in mitotic cell cycle
TAS
interspecies interaction between organisms
IEA
G1 phase
TAS
cell cycle checkpoint
null
myoblast differentiation
IMP
chromatin remodeling
TAS
cell cycle arrest
TAS
negative regulation of protein kinase activity
IPI
positive regulation of transcription, DNA-dependent
NAS
androgen receptor signaling pathway
NAS
M phase
NAS
phosphoprotein binding
IPI
transcriptional repressor activity
TAS
protein binding
IPI
transcription factor activity
null
transcription coactivator activity
NAS
androgen receptor binding
NAS
kinase binding
IDA
ubiquitin protein ligase binding
IPI
206
PCK1
D - Genome Maintenance
centrosome
IDA
nucleus
IDA
cytosol
EXP
glycerol biosynthetic process from pyruvate
ISS
gluconeogenesis
ISS
glucose homeostasis
ISS
carboxylic acid binding
IDA
manganese ion binding
IDA
magnesium ion binding
IDA
phosphoenolpyruvate carboxykinase (GTP) activity
TAS
GTP binding
IDA
297
DAXX
C - Cellular Fate and Organization
cytoplasm
TAS
PML body
TAS
nucleus
IDA
induction of apoptosis via death domain receptors
TAS
interspecies interaction between organisms
IEA
negative regulation of transcription
IDA
apoptosis
TAS
activation of JNK activity
TAS
negative regulation of transcription, DNA-dependent
IDA
androgen receptor signaling pathway
IDA
transcription
IEA
protein N-terminus binding
IPI
protein kinase binding
IPI
heat shock protein binding
TAS
androgen receptor binding
IPI
receptor signaling protein activity
TAS
protein homodimerization activity
IDA
identical protein binding
IPI
transcription factor binding
IDA
419
XRCC5
D - Genome Maintenance
nucleus
null
nucleoplasm
EXP
nuclear telomere cap complex
TAS
telomere maintenance
TAS
provirus integration
EXP
DNA recombination
TAS
initiation of viral infection
EXP
double-strand break repair via nonhomologous end joining
TAS
double-strand break repair
TAS
protein binding
IPI
double-stranded DNA binding
null
ATP-dependent DNA helicase activity
null
telomeric DNA binding
IDA
protein C-terminus binding
IPI
DNA binding
NAS
ATP binding
IEA
481
ERCC3
D - Genome Maintenance
nucleus
TAS
transcription factor TFIIH complex
IDA
hair cell differentiation
IMP
RNA elongation from RNA polymerase II promoter
EXP
transcription initiation from RNA polymerase II promoter
EXP
transcription from RNA polymerase II promoter
IMP
induction of apoptosis
IMP
protein localization
IMP
DNA repair
TAS
transcription-coupled nucleotide-excision repair
null
interspecies interaction between organisms
IEA
positive regulation of transcription from RNA polymerase II promoter
IDA
cell cycle checkpoint
IMP
nucleotide-excision repair, DNA duplex unwinding
IMP
nucleotide-excision repair, DNA damage removal
EXP
DNA topological change
IMP
response to oxidative stress
IMP
damaged DNA binding
null
protein N-terminus binding
IPI
ATP-dependent DNA helicase activity
IEA
RNA polymerase II transcription factor activity
null
3' to 5' DNA helicase activity
IDA
protein C-terminus binding
IPI
ATP binding
IEA
DNA helicase activity
null
transcription factor binding
IDA
DNA-dependent ATPase activity
IMP
1324
YWHAE
C - Cellular Fate and Organization
melanosome
IEA
cytosol
EXP
induction of apoptosis by extracellular signals
EXP
intracellular signaling cascade
null
interspecies interaction between organisms
IEA
apoptosis
EXP
protein binding
null
histone deacetylase binding
IPI
enzyme binding
IPI
phosphoserine binding
IPI
0
GHRHR
C - Cellular Fate and Organization
nuclear outer membrane
IDA
plasma membrane
null
cell surface
IDA
nuclear inner membrane
IDA
integral to membrane
null
secretory granule
IDA
nuclear matrix
IDA
adenylate cyclase activation
TAS
skeletal development
null
positive regulation of cell proliferation
IDA
response to estrogen stimulus
IDA
positive regulation of insulin-like growth factor receptor signaling pathway
NAS
positive regulation of cAMP biosynthetic process
IDA
response to glucocorticoid stimulus
IDA
G-protein signaling, adenylate cyclase activating pathway
IDA
positive regulation of body size
IMP
growth factor binding
IPI
G-protein coupled receptor activity
TAS
growth hormone-releasing hormone receptor activity
IMP
peptide hormone binding
IPI
206
EFEMP1
A - Transport and Sensing
extracellular matrix (sensu Metazoa)
TAS
visual perception
TAS
protein binding
IPI
calcium ion binding
IEA
237
PRKAR1A
C - Cellular Fate and Organization
protein complex
IDA
cAMP-dependent protein kinase complex
IEA
cytosol
EXP
intracellular signaling cascade
null
hormone-mediated signaling
EXP
regulation of transcription from RNA polymerase II promoter
null
regulation of protein amino acid phosphorylation
IEA
protein binding
IPI
cAMP binding
IEA
cAMP-dependent protein kinase regulator activity
TAS
0
SURF1
E - Energy Production
mitochondrial electron transport chain
TAS
integral to membrane
IEA
aerobic respiration
TAS
cytochrome c oxidase complex assembly
TAS
electron transport
TAS
cytochrome-c oxidase activity
TAS
551
BCR
C - Cellular Fate and Organization
intracellular
IEA
intracellular signaling cascade
IEA
signal transduction
null
regulation of Rho protein signal transduction
IEA
protein amino acid phosphorylation
null
protein serine/threonine kinase activity
null
Rho guanyl-nucleotide exchange factor activity
IEA
ATP binding
IEA
GTPase activator activity
null
747
ABL1
D - Genome Maintenance
perinuclear region
IDA
nuclear membrane
IEA
nucleolus
IDA
nucleus
NAS
cytoskeleton
IEA
cytosol
EXP
regulation of transcription, DNA-dependent
null
positive regulation of oxidoreductase activity
IDA
actin cytoskeleton organization and biogenesis
ISS
DNA damage response, signal transduction resulting in induction of apoptosis
null
S-phase-specific transcription in mitotic cell cycle
TAS
peptidyl-tyrosine phosphorylation
IDA
mismatch repair
null
cell adhesion
IEA
protein modification
NAS
regulation of progression through cell cycle
null
manganese ion binding
IDA
magnesium ion binding
IDA
protein-tyrosine kinase activity
null
protein C-terminus binding
IPI
ATP binding
IDA
non-membrane spanning protein tyrosine kinase activity
IEA
DNA binding
NAS
250
TAL1
C - Cellular Fate and Organization
nucleus
IDA
cell fate commitment
ISS
cell proliferation
null
positive regulation of erythrocyte differentiation
ISS
erythrocyte differentiation
ISS
transcription
IEA
transcription factor activity
IDA
histone deacetylase binding
IPI
DNA binding
null
206
GPX4
E - Energy Production
mitochondrion
null
multicellular organismal development
IEA
phospholipid metabolic process
TAS
electron transport
TAS
glutathione peroxidase activity
TAS
selenium binding
IEA
electron transporter activity
null
phospholipid-hydroperoxide glutathione peroxidase activity
IEA
34
DNMT3A
B - Transcriptional Control
cytoplasm
null
euchromatin
ISS
nucleus
ISS
nuclear matrix
ISS
DNA methylation
ISS
imprinting
ISS
protein binding
IPI
DNA (cytosine-5-)-methyltransferase activity
ISS
zinc ion binding
IEA
DNA binding
null
215
MYB
T - Transcription
nuclear matrix
null
regulation of transcription, DNA-dependent
null
transcription
IEA
protein binding
IPI
transcriptional activator activity
null
DNA binding
IEA
271
NOTCH1
T - Transcription
plasma membrane
IEA
nucleus
TAS
integral to membrane
null
negative regulation of BMP signaling pathway
TAS
immune response
null
negative regulation of osteoblast differentiation
TAS
Notch signaling pathway
TAS
regulation of transcription
TAS
negative regulation of myoblast differentiation
IMP
transcription
IEA
protein binding
IPI
calcium ion binding
IEA
receptor activity
IEA
216
PIM1
D - Genome Maintenance
cytoplasm
null
plasma membrane
IEA
nucleus
IEA
cell cycle
IEA
G1/S-specific positive regulation of cyclin-dependent protein kinase activity
IDA
negative regulation of apoptosis
IDA
protein amino acid autophosphorylation
IMP
cell proliferation
IDA
protein amino acid phosphorylation
null
multicellular organismal development
null
negative regulation of transcription factor activity
IDA
protein binding
IPI
manganese ion binding
IDA
protein serine/threonine kinase activity
null
ATP binding
IDA
transcription factor binding
IPI
423
ERG
C - Cellular Fate and Organization
cytoplasm
IEA
ribonucleoprotein complex
IDA
nucleus
null
signal transduction
null
regulation of transcription, DNA-dependent
IEA
cell proliferation
null
protein amino acid phosphorylation
null
multicellular organismal development
null
transcription
IEA
protein binding
IPI
sequence-specific DNA binding
IEA
transcription factor activity
IEA
signal transducer activity
null
DNA binding
null
211
CBLB
C - Cellular Fate and Organization
cytoplasm
IEA
nucleus
IEA
signal transduction
null
immune response
IEA
modification-dependent protein catabolic process
IEA
NLS-bearing substrate import into nucleus
TAS
cell surface receptor linked signal transduction
IEA
protein binding
null
ligase activity
IEA
calcium ion binding
IEA
zinc ion binding
null
signal transducer activity
IEA
527
NPM1
D - Genome Maintenance
centrosome
IDA
cytoplasm
IDA
nucleolus
IDA
spindle pole centrosome
IDA
nucleus
IDA
negative regulation of cell proliferation
IMP
ribosome assembly
TAS
centrosome cycle
IMP
cell aging
IMP
response to stress
IMP
nucleosome assembly
IDA
anti-apoptosis
TAS
protein oligomerization
IDA
intracellular protein transport
TAS
nucleocytoplasmic transport
TAS
signal transduction
TAS
activation of NF-kappaB transcription factor
IMP
interspecies interaction between organisms
IEA
histone binding
IDA
NF-kappaB binding
IDA
protein heterodimerization activity
IMP
RNA binding
TAS
transcription coactivator activity
IDA
ribosomal large subunit binding
IDA
unfolded protein binding
IDA
ribosomal small subunit binding
IDA
Tat protein binding
IDA
protein homodimerization activity
IDA
417
EZH2
D - Genome Maintenance
ESC/E(Z) complex
IDA
regulation of transcription, DNA-dependent
TAS
negative regulation of retinoic acid receptor signaling pathway
IMP
establishment and/or maintenance of chromatin architecture
TAS
chromatin modification
IEA
transcription
IEA
transcriptional repressor activity
IMP
protein binding
IPI
DNA binding
null
histone methyltransferase activity
IDA
histone-lysine N-methyltransferase activity
IEA
206
ARHGEF12
C - Cellular Fate and Organization
membrane
IEA
cytosol
EXP
intracellular signaling cascade
IEA
induction of apoptosis by extracellular signals
EXP
G-protein coupled receptor protein signaling pathway
IDA
regulation of Rho protein signal transduction
IEA
apoptosis
EXP
protein binding
IPI
G-protein-coupled receptor binding
IDA
Rho guanyl-nucleotide exchange factor activity
IEA
GTPase activator activity
IEA
206
AKT2
C - Cellular Fate and Organization
nucleus
IDA
cytosol
EXP
insulin receptor signaling pathway
IMP
positive regulation of glycogen biosynthetic process
IMP
positive regulation of glucose import
IMP
positive regulation of fatty acid beta-oxidation
IMP
protein amino acid phosphorylation
IEA
protein modification
null
protein binding
IPI
protein serine/threonine kinase activity
null
ATP binding
IEA
206
ALK
C - Cellular Fate and Organization
integral to plasma membrane
TAS
integral to membrane
null
protein amino acid autophosphorylation
IDA
brain development
TAS
protein amino acid N-linked glycosylation
IMP
transmembrane receptor protein tyrosine kinase signaling pathway
IEA
nervous system development
IMP
protein binding
IPI
transmembrane receptor protein tyrosine kinase activity
IDA
ATP binding
IEA
receptor signaling protein tyrosine kinase activity
TAS
390
CHEK2
D - Genome Maintenance
PML body
IDA
nucleus
null
senescence (sensu Magnoliophyta)
IDA
cell cycle
IEA
DNA damage response, signal transduction resulting in induction of apoptosis
IDA
protein amino acid phosphorylation
IEA
DNA damage checkpoint
null
response to DNA damage stimulus
null
protein binding
IPI
magnesium ion binding
IEA
protein serine/threonine kinase activity
null
ATP binding
IEA
275
PPARG
C - Cellular Fate and Organization
nucleus
IDA
cytosol
ISS
lipid metabolic process
TAS
low-density lipoprotein receptor biosynthetic process
IDA
regulation of transcription from RNA polymerase II promoter
null
caspase activation
IDA
response to nutrient
TAS
glucose homeostasis
IMP
placenta development
ISS
generation of precursor metabolites and energy
TAS
induction of apoptosis
IDA
transcription
IEA
signal transduction
null
positive regulation of transcription factor activity
IDA
lipoprotein transport
IDA
cell fate commitment
ISS
white fat cell differentiation
TAS
innate immune response
TAS
epithelial cell differentiation
ISS
blood pressure regulation
IMP
positive regulation of fat cell differentiation
ISS
monocyte differentiation
IDA
cell maturation
IDA
long-chain fatty acid transport
ISS
protein binding
IPI
specific transcriptional repressor activity
ISS
transcription factor activity
null
protein heterodimerization activity
TAS
arachidonic acid binding
ISS
transcriptional activator activity
ISS
steroid hormone receptor activity
IEA
prostaglandin receptor activity
TAS
retinoid X receptor binding
IDA
drug binding
IDA
zinc ion binding
IEA
ligand-dependent nuclear receptor activity
TAS
269
ERCC4
D - Genome Maintenance
nucleotide-excision repair complex
IDA
nucleoplasm
EXP
nuclear chromosome, telomeric region
IDA
nucleotide-excision repair, DNA incision, 3'-to lesion
IMP
nucleotide-excision repair, DNA incision, 5'-to lesion
IMP
double-strand break repair via homologous recombination
IMP
negative regulation of telomere maintenance
IMP
nucleotide-excision repair
IDA
nucleotide-excision repair, DNA damage removal
EXP
damaged DNA binding
IMP
protein N-terminus binding
IPI
magnesium ion binding
IEA
single-stranded DNA binding
IDA
endodeoxyribonuclease activity
TAS
protein C-terminus binding
IPI
376
ELL
T - Transcription
Cajal body
IEA
nuclear speck
IEA
transcription elongation factor complex
IEA
RNA elongation from RNA polymerase II promoter
TAS
regulation of transcription
IEA
protein binding
IPI
positive transcription elongation factor activity
TAS
RNA polymerase II transcription elongation factor activity
IEA
720
JAK2
D - Genome Maintenance
cytoskeleton
IEA
endomembrane system
IEA
intracellular signaling cascade
null
positive regulation of tyrosine phosphorylation of Stat3 protein
ISS
positive regulation of tyrosine phosphorylation of Stat5 protein
ISS
cell motility
null
mesoderm development
TAS
protein amino acid phosphorylation
null
JAK-STAT cascade
TAS
response to antibiotic
IDA
regulation of progression through cell cycle
null
growth hormone receptor binding
ISS
receptor binding
IPI
protein-tyrosine kinase activity
null
SH2 domain binding
null
ATP binding
IEA
non-membrane spanning protein tyrosine kinase activity
IEA
212
MLLT4
C - Cellular Fate and Organization
adherens junction
IEA
intercellular junction
TAS
cytosol
EXP
signal transduction
null
cell-cell signaling
TAS
cell adhesion
null
protein C-terminus binding
null
570
TXN
C - Cellular Fate and Organization
cytosol
EXP
signal transduction
null
cell proliferation
null
transport
IEA
cell-cell signaling
null
cell motility
null
cell redox homeostasis
IEA
protein binding
IPI
thiol-disulfide exchange intermediate activity
TAS
209
TERT
C - Cellular Fate and Organization
telomerase holoenzyme complex
IDA
chromosome, telomeric region
null
nucleoplasm
EXP
nuclear telomere cap complex
IC
senescence (sensu Magnoliophyta)
IMP
telomere maintenance
TAS
DNA strand elongation
IDA
telomere formation via telomerase
IDA
anti-apoptosis
IMP
telomere maintenance via telomerase
IMP
protein binding
IPI
telomeric template RNA reverse transcriptase activity
TAS
telomeric DNA binding
null
protein homodimerization activity
IDA
206
ZMPSTE24
F - Protein Fate
Golgi membrane
IEA
endoplasmic reticulum membrane
IEA
integral to membrane
IEA
proteolysis
null
metalloexopeptidase activity
TAS
zinc ion binding
IEA
1607
SHC1
D - Genome Maintenance
plasma membrane
null
mitochondrial matrix
IEA
cytosol
EXP
insulin receptor signaling pathway
ISS
activation of MAPK activity
null
positive regulation of cell proliferation
null
epidermal growth factor receptor signaling pathway
TAS
positive regulation of DNA replication
ISS
regulation of epidermal growth factor receptor activity
TAS
positive regulation of mitosis
NAS
Ras protein signal transduction
EXP
regulation of growth
IEA
protein binding
IPI
epidermal growth factor receptor binding
ISS
phospholipid binding
TAS
insulin-like growth factor receptor binding
IPI
insulin receptor binding
IPI
transmembrane receptor protein tyrosine kinase adaptor protein activity
TAS
602
HSP90AB1
M - Other Metabolism
melanosome
IEA
cytoplasm
null
response to unfolded protein
NAS
protein folding
IEA
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
IMP
positive regulation of nitric oxide biosynthetic process
ISS
TPR domain binding
ISS
heat shock protein activity
null
unfolded protein binding
IEA
nitric-oxide synthase regulator activity
ISS
ATP binding
IEA
226
MSH6
D - Genome Maintenance
MutSalpha complex
IDA
DNA damage response, signal transduction resulting in induction of apoptosis
ISS
isotype switching
ISS
somatic hypermutation of immunoglobulin genes
ISS
determination of adult life span
ISS
meiotic mismatch repair
ISS
base-excision repair
IDA
positive regulation of helicase activity
IDA
response to magnesium ion
IDA
short patch mismatch repair system
IDA
mismatch repair
null
response to UV
ISS
negative regulation of DNA recombination
IDA
protein binding
IPI
damaged DNA binding
null
dinucleotide insertion or deletion binding
IMP
purine-specific mismatch base pair DNA N-glycosylase activity
IMP
ATP binding
IEA
1103
AKT1
C - Cellular Fate and Organization
cytoplasm
ISS
plasma membrane
IDA
nucleoplasm
EXP
cytosol
EXP
insulin receptor signaling pathway
IMP
response to heat
TAS
positive regulation of cell growth
IDA
negative regulation of fatty acid beta-oxidation
IMP
activated T cell apoptosis
IMP
nitric oxide biosynthetic process
TAS
positive regulation of nitric oxide biosynthetic process
IMP
positive regulation of lipid biosynthetic process
IMP
protein amino acid autophosphorylation
TAS
peptidyl-serine phosphorylation
IDA
positive regulation of glucose import
IMP
protein import into nucleus, translocation
IMP
activation of pro-apoptotic gene products
EXP
positive regulation of glycogen biosynthetic process
IMP
glycogen biosynthetic process
IEA
anti-apoptosis
null
regulation of translation
IEA
signal transduction
null
G1/S-specific positive regulation of cyclin-dependent protein kinase activity
IDA
G-protein coupled receptor protein signaling pathway
null
positive regulation of nitric-oxide synthase activity
IMP
positive regulation of fat cell differentiation
IMP
insulin-like growth factor receptor signaling pathway
IMP
negative regulation of protein kinase activity
IMP
protein modification
null
protein serine/threonine kinase activity
null
phosphatidylinositol-3,4-bisphosphate binding
IDA
phosphatidylinositol-3,4,5-triphosphate binding
IDA
nitric-oxide synthase regulator activity
IMP
enzyme binding
ISS
ATP binding
IC
identical protein binding
IPI
431
CDK6
D - Genome Maintenance
cytoplasm
IDA
cyclin-dependent protein kinase holoenzyme complex
IDA
nucleus
IDA
ruffle
IDA
cell proliferation
null
negative regulation of epithelial cell proliferation
IMP
positive regulation of fibroblast proliferation
IMP
response to virus
IEP
negative regulation of progression through cell cycle
IDA
gliogenesis
IMP
negative regulation of osteoblast differentiation
IDA
regulation of erythrocyte differentiation
IMP
protein amino acid phosphorylation
IDA
G1 phase of mitotic cell cycle
TAS
regulation of progression through cell cycle
null
positive regulation of cell-matrix adhesion
IDA
cell division
IEA
protein binding
IPI
protein kinase activity
TAS
cyclin binding
IPI
ATP binding
IDA
cyclin-dependent protein kinase activity
IDA
411
RPN1
P - Translation
melanosome
IEA
rough endoplasmic reticulum membrane
ISS
endoplasmic reticulum lumen
null
integral to membrane
IEA
oligosaccharyl transferase complex
TAS
protein modification
null
protein amino acid N-linked glycosylation via asparagine
TAS
oligosaccharyl transferase activity
null
protein binding
IPI
dolichyl-diphosphooligosaccharide-protein glycotransferase activity
IEA
206
ELK4
T - Transcription
nucleus
IEA
regulation of transcription, DNA-dependent
IEA
sequence-specific DNA binding
IEA
protein binding
null
transcription cofactor activity
TAS
transcription factor activity
NAS
DNA binding
null
216
MSN
C - Cellular Fate and Organization
cytoplasm
IDA
apical plasma membrane
IEA
plasma membrane
null
nucleolus
IDA
microvillus membrane
IEA
filopodium
IDA
cytoskeleton
null
extrinsic to membrane
IEA
leukocyte adhesion
IEP
cell motility
TAS
membrane to membrane docking
IEP
leukocyte migration
IEP
receptor binding
IPI
structural constituent of cytoskeleton
TAS
cell adhesion molecule binding
IPI
212
SYK
C - Cellular Fate and Organization
cytoplasm
IEA
T cell receptor complex
IDA
protein complex assembly
null
integrin-mediated signaling pathway
NAS
cell proliferation
null
interspecies interaction between organisms
IEA
neutrophil chemotaxis
IDA
leukocyte adhesion
IDA
organ morphogenesis
TAS
protein amino acid phosphorylation
TAS
protein binding
IPI
integrin binding
IPI
protein-tyrosine kinase activity
TAS
non-membrane spanning protein tyrosine kinase activity
IEA
ATP binding
IEA
212
HLF
T - Transcription
nucleus
null
regulation of transcription, DNA-dependent
IEA
transcription from RNA polymerase II promoter
TAS
multicellular organismal development
TAS
rhythmic process
IEA
sequence-specific DNA binding
IEA
double-stranded DNA binding
TAS
transcription factor activity
IEA
protein dimerization activity
IEA
DNA binding
TAS
232
CCND3
D - Genome Maintenance
cytoplasm
IEA
cyclin-dependent protein kinase holoenzyme complex
IDA
nucleus
IEA
cell cycle
IEA
positive regulation of protein amino acid phosphorylation
IDA
positive regulation of cyclin-dependent protein kinase activity
IDA
regulation of progression through cell cycle
null
cell division
IEA
protein binding
IPI
protein kinase binding
IPI
206
HELLS
D - Genome Maintenance
centric heterochromatin
ISS
nucleus
IEA
centric heterochromatin formation
ISS
maintenance of DNA methylation
ISS
mitosis
IEA
methylation-dependent chromatin silencing
ISS
lymphocyte proliferation
ISS
multicellular organismal development
ISS
cell division
IEA
transcription
IEA
ATP-dependent helicase activity
null
hydrolase activity
null
helicase activity
IEA
ATP binding
IEA
DNA binding
null
211
HMGA1
C - Cellular Fate and Organization
transcription factor complex
TAS
chromatin
IEA
cytosol
EXP
regulation of transcription, DNA-dependent
null
protein complex assembly
TAS
positive regulation of transcription
IMP
provirus integration
EXP
interspecies interaction between organisms
IEA
loss of chromatin silencing
TAS
DNA unwinding during replication
NAS
nucleosome disassembly
TAS
initiation of viral infection
EXP
transmembrane receptor protein tyrosine kinase signaling pathway
NAS
transcription
IEA
retinoid X receptor binding
IDA
transcription factor activity
IMP
ligand-dependent nuclear receptor transcription coactivator activity
IMP
AT DNA binding
null
enzyme binding
IPI
peroxisome proliferator activated receptor binding
IDA
0
PAPPA
C - Cellular Fate and Organization
membrane
IEA
extracellular region
IDA
pregnancy
NAS
cell differentiation
IEA
zinc ion binding
null
metallopeptidase activity
IDA
206
ERCC5
D - Genome Maintenance
nucleoplasm
EXP
negative regulation of apoptosis
IMP
response to UV-C
IMP
UV protection
IGI
nucleotide-excision repair, DNA incision, 3'-to lesion
IDA
transcription-coupled nucleotide-excision repair
TAS
nucleotide-excision repair, DNA damage removal
EXP
protein N-terminus binding
IPI
double-stranded DNA binding
IDA
magnesium ion binding
IEA
single-stranded DNA binding
IDA
bubble DNA binding
IDA
endodeoxyribonuclease activity
null
protein homodimerization activity
IPI
209
SIRT6
B - Transcriptional Control
nuclear telomeric heterochromatin
IDA
nucleoplasm
IDA
nucleus
ISS
protein amino acid ADP-ribosylation
ISS
chromatin silencing
IEA
protein amino acid deacetylation
IEA
protein binding
IPI
NAD(P)+-protein-arginine ADP-ribosyltransferase activity
ISS
zinc ion binding
ISS
NAD-dependent histone deacetylase activity (H3-K9 specific)
IDA
NAD+ ADP-ribosyltransferase activity
TAS
232
IRF4
C - Cellular Fate and Organization
cytoplasm
IDA
nucleus
null
positive regulation of interleukin-2 biosynthetic process
IDA
T cell activation
NAS
positive regulation of transcription
IDA
positive regulation of interleukin-4 biosynthetic process
IDA
positive regulation of interleukin-13 biosynthetic process
IDA
regulation of T-helper cell differentiation
NAS
positive regulation of interleukin-10 biosynthetic process
IDA
transcription
IEA
transcription factor activity
NAS
RNA polymerase II transcription factor activity
null
transcriptional activator activity
IDA
transcription factor binding
NAS
351
PIK3CA
C - Cellular Fate and Organization
phosphoinositide phosphorylation
IEA
phosphoinositide-mediated signaling
IEA
protein binding
IPI
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
EXP
phosphatidylinositol 3-kinase activity
IDA
ATP binding
IEA
574
RAF1
C - Cellular Fate and Organization
plasma membrane
EXP
mitochondrial outer membrane
null
cytosol
EXP
signal transduction
null
negative regulation of cell proliferation
IDA
cell proliferation
null
apoptosis
null
protein amino acid phosphorylation
null
Ras protein signal transduction
EXP
protein binding
IPI
protein kinase activity
null
protein serine/threonine kinase activity
IEA
zinc ion binding
IEA
receptor signaling protein activity
IEA
ATP binding
IEA
206
FH
E - Energy Production
mitochondrion
null
cytoplasm
TAS
mitochondrial matrix
EXP
tricarboxylic acid cycle enzyme complex
IEA
tricarboxylic acid cycle
IEA
fumarate metabolic process
TAS
fumarate hydratase activity
TAS
249
BCL3
D - Genome Maintenance
protein complex
IDA
cytoplasm
IDA
nucleus
IDA
regulation of NF-kappaB import into nucleus
IEP
negative regulation of apoptosis
IDA
negative regulation of interleukin-8 biosynthetic process
IMP
cytoplasmic sequestering of NF-kappaB
TAS
I-kappaB kinase/NF-kappaB cascade
IDA
positive regulation of protein biosynthetic process
IMP
response to virus
IDA
transcription
IEA
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
IMP
response to UV-C
IDA
maintenance of protein localization in nucleus
NAS
regulation of DNA binding
IEP
negative regulation of transcription
IDA
regulation of progression through cell cycle
null
protein import into nucleus, translocation
IMP
protein binding
IPI
protein binding, bridging
TAS
transcription factor binding
IPI
304
FANCA
D - Genome Maintenance
cytoplasm
null
nucleus
null
protein complex assembly
null
DNA repair
null
protein binding
IPI
206
KLF6
C - Cellular Fate and Organization
nucleus
TAS
regulation of transcription, DNA-dependent
null
B cell differentiation
NAS
transcription
IEA
transcriptional activator activity
null
zinc ion binding
IEA
206
MET
C - Cellular Fate and Organization
basal plasma membrane
IDA
integral to plasma membrane
null
signal transduction
null
hepatocyte growth factor receptor signaling pathway
IEA
cell proliferation
null
protein amino acid phosphorylation
IEA
multicellular organismal development
IEA
cell surface receptor linked signal transduction
NAS
hepatocyte growth factor receptor activity
TAS
protein binding
IPI
protein-tyrosine kinase activity
NAS
ATP binding
IEA
477
FOXO3
C - Cellular Fate and Organization
cytoplasm
null
nucleus
null
cytosol
IEA
transcription from RNA polymerase II promoter
null
positive regulation of erythrocyte differentiation
IDA
positive regulation of transcription from RNA polymerase II promoter
IDA
apoptosis
IDA
induction of apoptosis
null
transcription
IEA
sequence-specific DNA binding
IDA
transcription factor activity
IDA
protein kinase binding
IPI
transcriptional activator activity
IDA
206
CCND2
D - Genome Maintenance
cyclin-dependent protein kinase holoenzyme complex
IDA
nucleus
IEA
cell cycle
IEA
positive regulation of protein amino acid phosphorylation
IDA
positive regulation of cyclin-dependent protein kinase activity
IDA
regulation of progression through cell cycle
NAS
cell division
IEA
protein binding
IPI
protein kinase binding
IPI
206
BUB3
D - Genome Maintenance
condensed chromosome kinetochore
IEA
kinetochore
null
nucleus
IDA
cytosol
EXP
mitosis
null
mitotic checkpoint
null
meiosis
IEA
cell proliferation
null
negative regulation of ubiquitin ligase activity during mitotic cell cycle
EXP
attachment of spindle microtubules to kinetochore
IDA
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
EXP
cell division
IEA
protein binding
IPI
2249
TP53
D - Genome Maintenance
mitochondrion
IDA
protein complex
IDA
cytoplasm
IDA
endoplasmic reticulum
IEA
PML body
IDA
nucleolus
IDA
nucleoplasm
IDA
nucleus
null
insoluble fraction
IDA
nuclear matrix
IDA
negative regulation of cell growth
IMP
ER overload response
IDA
cell proliferation
TAS
Ras protein signal transduction
IEP
cell differentiation
TAS
protein localization
IDA
interspecies interaction between organisms
IEA
cell cycle arrest
TAS
cellular response to glucose starvation
IDA
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
IMP
regulation of mitochondrial membrane permeability
TAS
regulation of transcription, DNA-dependent
IDA
caspase activation via cytochrome c
IDA
protein tetramerization
TAS
DNA damage response, signal transduction resulting in induction of apoptosis
null
cell aging
IMP
response to tumor cell
IEA
apoptosis
IDA
DNA recombination
null
negative regulation of helicase activity
TAS
response to DNA damage stimulus
IEP
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
IDA
DNA repair
null
protein complex assembly
IDA
base-excision repair
TAS
cell cycle checkpoint
null
nucleotide-excision repair
IMP
G1 DNA damage checkpoint
IMP
regulation of progression through cell cycle
TAS
induction of apoptosis by hormones
null
transcription factor activity
null
protein heterodimerization activity
IPI
copper ion binding
IDA
transcriptional activator activity
IMP
chaperone binding
IPI
ATP binding
IDA
nuclease activity
TAS
protein N-terminus binding
IPI
chromatin binding
IDA
zinc ion binding
TAS
enzyme binding
IPI
transcription factor binding
IPI
DNA strand annealing activity
IDA
371
LMNA
C - Cellular Fate and Organization
perinuclear region
IDA
cytoplasm
IDA
plasma membrane
IDA
lamin filament
TAS
muscle development
null
protein binding
null
structural molecule activity
null
206
AFF3
T - Transcription
nucleus
null
multicellular organismal development
null
regulation of transcription
IEA
transcription
IEA
DNA binding
IEA
285
REL
C - Cellular Fate and Organization
nucleus
IEA
positive regulation of I-kappaB kinase/NF-kappaB cascade
IEP
transcription
IEA
protein binding
IPI
transcription factor activity
NAS
signal transducer activity
null
206
TPR
D - Genome Maintenance
cytoplasm
null
nuclear membrane
IEA
nuclear pore
null
nucleoplasm
EXP
mitotic spindle checkpoint
IMP
seryl-tRNA aminoacylation
IEA
mRNA transport
IEA
protein import into nucleus
TAS
protein binding
IPI
serine-tRNA ligase activity
IEA
ATP binding
IEA
614
FGFR2
C - Cellular Fate and Organization
plasma membrane
EXP
cell surface
IEP
membrane
NAS
extracellular region
IEA
nucleus
IDA
integral to membrane
null
cell cortex
IDA
positive regulation of cell proliferation
IGI
fibroblast growth factor receptor signaling pathway
IGI
cell growth
NAS
protein amino acid phosphorylation
null
protein binding
IPI
fibroblast growth factor receptor activity
NAS
fibroblast growth factor binding
IPI
protein-tyrosine kinase activity
null
ATP binding
IEA
heparin binding
IEA
0
COQ7
N - Not Matched
mitochondrion
TAS
mitochondrial inner membrane
IEA
nucleus
IDA
ubiquinone biosynthetic process
TAS
protein metabolic process
IEA
iron ion binding
IEA
oxidoreductase activity
IEA
208
FOXM1
D - Genome Maintenance
nucleus
IEA
senescence (sensu Magnoliophyta)
IMP
positive regulation of cell proliferation
IMP
cell cycle
TAS
regulation of transcription, DNA-dependent
IEA
transcription from RNA polymerase II promoter
null
regulation of cell proliferation
NAS
regulation of Ras protein signal transduction
IMP
response to oxidative stress
null
regulation of cell growth
TAS
transcription
IEA
sequence-specific DNA binding
IEA
protein binding
IPI
transcription factor activity
null
RNA polymerase II transcription factor activity
null
351
BCL2
D - Genome Maintenance
nuclear membrane
IDA
endoplasmic reticulum membrane
IEA
mitochondrial outer membrane
IDA
integral to membrane
IEA
protein polyubiquitination
IDA
regulation of protein homodimerization
IDA
activation of pro-apoptotic gene products
EXP
regulation of protein heterodimerization
IDA
regulation of mitochondrial membrane permeability
ISS
pregnancy
NAS
negative regulation of cell proliferation
null
response to drug
IDA
regulation of mitochondrial membrane potential
ISS
response to toxin
IDA
anti-apoptosis
null
release of cytochrome c from mitochondria
NAS
neuron apoptosis
TAS
defense response to virus
IDA
negative regulation of neuron apoptosis
IDA
negative regulation of mitochondrial depolarization
TAS
B cell proliferation
IDA
humoral immune response
TAS
response to iron ion
IDA
regulation of progression through cell cycle
null
response to nicotine
IDA
protein binding
null
protein heterodimerization activity
IPI
BH3 domain binding
IPI
transcriptional activator activity
IDA
protease binding
IDA
protein homodimerization activity
IDA
identical protein binding
IPI
206
RET
C - Cellular Fate and Organization
integral to membrane
IEA
signal transduction
null
posterior midgut development
TAS
protein amino acid phosphorylation
null
homophilic cell adhesion
IEA
calcium ion binding
IEA
receptor activity
null
protein-tyrosine kinase activity
null
transmembrane receptor protein tyrosine kinase activity
IEA
ATP binding
IEA
206
NTRK3
C - Cellular Fate and Organization
integral to plasma membrane
null
transmembrane receptor protein tyrosine kinase signaling pathway
null
neurotrophin binding
TAS
transmembrane receptor protein tyrosine kinase activity
IEA
ATP binding
IEA
neurotrophin TRKC receptor activity
null
206
MPL
C - Cellular Fate and Organization
integral to plasma membrane
null
cell proliferation
null
cell surface receptor linked signal transduction
TAS
hematopoietin/interferon-class (D200-domain) cytokine receptor activity
IEA
transmembrane receptor activity
TAS
209
DDX10
M - Other Metabolism
ATP-dependent helicase activity
IEA
RNA helicase activity
TAS
RNA binding
IEA
ATP binding
IEA
293
BRCA2
D - Genome Maintenance
centrosome
IDA
nucleoplasm
EXP
nucleus
null
secretory granule
TAS
extracellular space
null
centrosome duplication
IDA
response to estrogen stimulus
IDA
mitotic checkpoint
NAS
regulation of transcription, DNA-dependent
IC
double-strand break repair via homologous recombination
null
establishment and/or maintenance of chromatin architecture
null
chromatin remodeling
null
nucleotide-excision repair
IMP
regulation of S phase of mitotic cell cycle
NAS
regulation of transcription
null
regulation of progression through cell cycle
null
protein binding
null
gamma-tubulin binding
IPI
single-stranded DNA binding
null
transcriptional activator activity
IDA
412
CEBPB
T - Transcription
nucleus
null
immune response
TAS
inflammatory response
TAS
transcription from RNA polymerase II promoter
null
acute-phase response
TAS
protein binding
IPI
transcription factor activity
NAS
RNA polymerase II transcription factor activity, enhancer binding
ISS
DNA binding
null
242
FLI1
T - Transcription
nucleus
IEA
hemostasis
TAS
organ morphogenesis
null
transcription
IEA
sequence-specific DNA binding
IEA
protein binding
IPI
transcription factor activity
null
1212
EP300
D - Genome Maintenance
cytoplasm
IDA
nucleus
IDA
response to hypoxia
IDA
apoptosis
IMP
homeostatic process
TAS
N-terminal peptidyl-lysine acetylation
IDA
nervous system development
TAS
transcription
IEA
signal transduction
null
positive regulation of transcription factor activity
IDA
cell cycle
IEA
positive regulation of transcription from RNA polymerase II promoter
IMP
interspecies interaction between organisms
IEA
regulation of transcription
IDA
transcription factor activity
null
transcription coactivator activity
IDA
zinc ion binding
IEA
protein C-terminus binding
TAS
histone acetyltransferase activity
IDA
transcription factor binding
IPI
248
WRN
D - Genome Maintenance
centrosome
IDA
nucleolus
IDA
nucleoplasm
IDA
nucleus
null
response to UV-C
IDA
positive regulation of hydrolase activity
IDA
telomere maintenance
IMP
base-excision repair
IDA
aging
TAS
DNA synthesis during DNA repair
IDA
regulation of apoptosis
IGI
collapsed replication fork processing
IDA
multicellular organismal aging
IMP
DNA recombination
IEA
response to oxidative stress
IDA
protein binding
IPI
ATP-dependent 3' to 5' DNA helicase activity
IEA
3'-5' exonuclease activity
TAS
bubble DNA binding
IDA
Y-form DNA binding
IDA
G-quadruplex DNA binding
IDA
protein complex binding
IDA
ATP binding
IEA
DNA binding
null
protein homodimerization activity
IDA
DNA helicase activity
TAS
Holliday junction helicase activity
IDA
1393
BRCA1
D - Genome Maintenance
transcription factor complex
null
ribonucleoprotein complex
IDA
ubiquitin ligase complex
NAS
nucleoplasm
EXP
nucleus
null
BRCA1-BARD1 complex
IDA
extracellular space
null
gamma-tubulin ring complex
NAS
response to estrogen stimulus
IDA
protein ubiquitination
NAS
G2/M transition DNA damage checkpoint
IMP
positive regulation of DNA repair
NAS
postreplication repair
IDA
chromosome segregation
IMP
double-strand break repair via homologous recombination
IDA
response to ionizing radiation
IMP
modification-dependent protein catabolic process
IEA
regulation of cell proliferation
TAS
positive regulation of protein ubiquitination
IDA
negative regulation of transcription
IDA
fatty acid biosynthetic process
IEA
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
TAS
regulation of transcription from RNA polymerase II promoter
null
DNA damage response, signal transduction resulting in induction of apoptosis
IDA
regulation of transcription from RNA polymerase III promoter
TAS
negative regulation of fatty acid biosynthetic process
IMP
apoptosis
TAS
regulation of apoptosis
null
negative regulation of centriole replication
NAS
cell cycle
IEA
long-chain fatty acid biosynthetic process
IDA
positive regulation of transcription, DNA-dependent
NAS
androgen receptor signaling pathway
NAS
protein binding
null
tubulin binding
NAS
ligase activity
IEA
RNA binding
IDA
transcriptional activator activity
null
transcription coactivator activity
null
zinc ion binding
null
androgen receptor binding
NAS
enzyme binding
IPI
DNA binding
null
identical protein binding
IPI
208
PTEN
C - Cellular Fate and Organization
cytoplasm
IDA
nucleus
IDA
cytosol
EXP
negative regulation of protein kinase B signaling cascade
IMP
negative regulation of cell migration
IMP
negative regulation of cell proliferation
IMP
cell proliferation
TAS
apoptosis
IEA
multicellular organismal development
null
induction of apoptosis
ISS
regulation of cyclin-dependent protein kinase activity
null
central nervous system development
ISS
negative regulation of focal adhesion formation
IMP
heart development
ISS
regulation of protein stability
IMP
protein amino acid dephosphorylation
IDA
cell migration
ISS
inositol phosphate dephosphorylation
IDA
phosphoinositide dephosphorylation
IDA
protein binding
IPI
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
IDA
magnesium ion binding
IEA
PDZ domain binding
IPI
lipid binding
IEA
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
IDA
phosphatidylinositol-3-phosphatase activity
IDA
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
IDA
inositol or phosphatidylinositol phosphatase activity
null
protein tyrosine/serine/threonine phosphatase activity
IEA
protein serine/threonine phosphatase activity
IDA
protein tyrosine phosphatase activity
IDA
411
BAX
C - Cellular Fate and Organization
mitochondrial permeability transition pore
IDA
endoplasmic reticulum membrane
IDA
mitochondrial outer membrane
EXP
cytosol
IDA
negative regulation of survival gene product activity
TAS
regulation of protein homodimerization
IDA
induction of apoptosis by extracellular signals
TAS
regulation of protein heterodimerization
IPI
B cell apoptosis
IDA
caspase activation via cytochrome c
IDA
induction of retinal programmed cell death
IMP
transformed cell apoptosis
IMP
regulation of mitochondrial membrane potential
IDA
response to toxin
IDA
release of cytochrome c from mitochondria
IDA
establishment and/or maintenance of transmembrane electrochemical gradient
IDA
mitochondrial fragmentation during apoptosis
IDA
germ cell development
TAS
cleavage of lamin
IMP
positive regulation of neuron apoptosis
IDA
mitochondrial fusion
IDA
apoptotic mitochondrial changes
null
DNA fragmentation during apoptosis
IMP
nuclear fragmentation during apoptosis
IMP
protein homooligomerization
IDA
induction of apoptosis by intracellular signals
IDA
protein binding
ISS
protein heterodimerization activity
IPI
BH3 domain binding
IPI
protein homodimerization activity
IDA
lipid binding
IDA
208
PRDM1
T - Transcription
nucleus
IEA
negative regulation of transcription from RNA polymerase II promoter
null
transcription
IEA
transcription factor activity
null
zinc ion binding
IEA
220
IRS2
C - Cellular Fate and Organization
plasma membrane
EXP
insulin receptor signaling pathway
ISS
signal transduction
null
positive regulation of glycogen biosynthetic process
IMP
positive regulation of B cell proliferation
ISS
positive regulation of glucose import
IMP
negative regulation of B cell apoptosis
ISS
positive regulation of fatty acid beta-oxidation
IMP
glucose metabolic process
TAS
positive regulation of insulin secretion
ISS
response to glucose stimulus
ISS
signal transducer activity
null
215
HRAS
D - Genome Maintenance
cytoplasm
null
Golgi membrane
IEA
plasma membrane
null
cytosol
EXP
positive regulation of cell proliferation
IDA
negative regulation of cell proliferation
IDA
G1/S transition checkpoint
IDA
positive regulation of DNA replication
IDA
Ras protein signal transduction
EXP
senescence (sensu Magnoliophyta)
IDA
chemotaxis
TAS
organ morphogenesis
TAS
cell cycle arrest
IDA
positive regulation of MAPKKK cascade
IDA
regulation of progression through cell cycle
NAS
cell surface receptor linked signal transduction
null
GTPase activity
IEA
GTP binding
IDA
protein C-terminus binding
IPI
277
JAK1
C - Cellular Fate and Organization
cytoplasm
IDA
membrane
IEA
nucleus
IDA
cytoskeleton
IEA
endomembrane system
IEA
intracellular signaling cascade
TAS
protein amino acid phosphorylation
null
response to antibiotic
IDA
Janus kinase activity
IEA
growth hormone receptor binding
ISS
protein-tyrosine kinase activity
TAS
ATP binding
IEA
non-membrane spanning protein tyrosine kinase activity
IEA
207
NTRK1
C - Cellular Fate and Organization
cytoplasm
ISS
integral to plasma membrane
null
endosome
EXP
adenylate cyclase activation
EXP
Ras protein signal transduction
EXP
transmembrane receptor protein tyrosine kinase signaling pathway
null
neurotrophin receptor activity
IEA
neurotrophin binding
TAS
transmembrane receptor protein tyrosine kinase activity
TAS
neurotrophin TRKA receptor activity
null
ATP binding
IEA
211
MDM4
C - Cellular Fate and Organization
nucleus
NAS
negative regulation of cell proliferation
null
protein complex assembly
IDA
negative regulation of protein catabolic process
IMP
cell proliferation
IEP
protein stabilization
IEP
apoptosis
IEP
negative regulation of transcription from RNA polymerase II promoter
IDA
G0 to G1 transition
IEP
protein binding
IPI
zinc ion binding
TAS
229
ERBB2
C - Cellular Fate and Organization
receptor complex
IDA
plasma membrane
NAS
integral to membrane
NAS
positive regulation of epithelial cell proliferation
IDA
cell proliferation
null
phosphoinositide-mediated signaling
NAS
regulation of angiogenesis
NAS
mammary gland development
TAS
phosphoinositide 3-kinase cascade
IDA
nervous system development
TAS
positive regulation of cell adhesion
IDA
heart development
TAS
protein amino acid autophosphorylation
IDA
positive regulation of MAPK activity
IDA
wound healing
IDA
protein amino acid phosphorylation
null
transmembrane receptor protein tyrosine kinase signaling pathway
IDA
enzyme linked receptor protein signaling pathway
null
epidermal growth factor receptor activity
NAS
protein heterodimerization activity
IDA
protein phosphatase binding
IPI
protein C-terminus binding
IPI
ATP binding
IEA
receptor signaling protein tyrosine kinase activity
TAS
ErbB-3 class receptor binding
null
identical protein binding
IPI
279
HIST1H4A
D - Genome Maintenance
nucleoplasm
EXP
nucleosome
TAS
negative regulation of megakaryocyte differentiation
IDA
phosphoinositide-mediated signaling
NAS
nucleosome assembly
IEA
establishment and/or maintenance of chromatin architecture
NAS
protein binding
IPI
DNA binding
TAS
206
POU1F1
C - Cellular Fate and Organization
nucleus
IEA
positive regulation of gene-specific transcription
IDA
negative regulation of cell proliferation
null
transcription from RNA polymerase II promoter
TAS
organ morphogenesis
null
sequence-specific DNA binding
IEA
transcription factor activity
IDA
206
IL6ST
C - Cellular Fate and Organization
plasma membrane
TAS
integral to plasma membrane
null
oncostatin-M receptor complex
IDA
extracellular region
IEA
interleukin-6 receptor complex
IDA
extracellular space
IDA
positive regulation of osteoblast differentiation
IMP
immune response
TAS
leukemia inhibitory factor signaling pathway
IGI
positive regulation of acute inflammatory response
IC
positive regulation of tyrosine phosphorylation of Stat3 protein
IMP
positive regulation of T cell proliferation
IMP
positive regulation of tyrosine phosphorylation of Stat1 protein
IMP
positive regulation of adaptive immune response
IC
positive regulation of anti-apoptosis
TAS
cell surface receptor linked signal transduction
TAS
protein binding
IPI
interleukin-6 receptor activity
TAS
oncostatin-M receptor activity
TAS
receptor activity
TAS
ciliary neurotrophic factor receptor activity
IDA
interleukin-27 receptor activity
IC
protein homodimerization activity
TAS
ciliary neurotrophic factor receptor binding
IPI
944
MYC
D - Genome Maintenance
nucleus
null
iron ion homeostasis
TAS
positive regulation of cell proliferation
IDA
ureteric bud branching
ISS
regulation of transcription from RNA polymerase II promoter
null
cell proliferation
null
regulation of telomere maintenance
IMP
cell cycle arrest
null
transcription
IEA
protein binding
IPI
transcription factor activity
null
207
BLM
D - Genome Maintenance
cytoplasm
IDA
PML body
IDA
nucleolus
IDA
lateral element
IDA
nuclear matrix
IDA
response to X-ray
IDA
replication fork protection
NAS
G2/M transition DNA damage checkpoint
NAS
DNA recombination
null
regulation of cyclin-dependent protein kinase activity
IMP
protein oligomerization
IDA
G2 phase of mitotic cell cycle
NAS
positive regulation of transcription
IDA
DNA repair
null
double-strand break repair via homologous recombination
NAS
collapsed replication fork processing
IDA
negative regulation of cell division
IMP
antimicrobial humoral response (sensu Vertebrata)
TAS
protein binding
IPI
p53 binding
IPI
ATP-dependent 3' to 5' DNA helicase activity
IEA
ATP-dependent DNA helicase activity
TAS
Holliday junction helicase activity
IDA
bubble DNA binding
IDA
helicase activity
TAS
G-quadruplex DNA binding
IDA
ATP binding
IDA
DNA strand annealing activity
IDA
0
ARHGAP1
C - Cellular Fate and Organization
cytoplasm
IEA
intracellular membrane-bound organelle
IDA
small GTPase mediated signal transduction
IDA
Rho protein signal transduction
TAS
protein binding
IPI
SH3 domain binding
IEA
SH3/SH2 adaptor activity
TAS
Rho GTPase activator activity
IDA
668
PIK3R1
C - Cellular Fate and Organization
phosphoinositide 3-kinase complex, class IA
ISS
1-phosphatidylinositol-4-phosphate kinase, class IA complex
ISS
insulin receptor signaling pathway
IPI
phosphoinositide phosphorylation
ISS
intracellular signaling cascade
null
positive regulation of glucose import
ISS
interspecies interaction between organisms
IEA
insulin-like growth factor receptor signaling pathway
IPI
phosphoinositide 3-kinase cascade
IDA
phosphatidylinositol binding
NAS
phosphoinositide 3-kinase regulator activity
ISS
insulin-like growth factor receptor binding
IPI
protein phosphatase binding
IPI
insulin receptor binding
IPI
phosphatidylinositol 3-kinase activity
null
insulin receptor substrate binding
ISS
insulin binding
IDA
ErbB-3 class receptor binding
IDA
206
POLG
D - Genome Maintenance
mitochondrion
TAS
mitochondrial nucleoid
IDA
gamma DNA polymerase complex
IEA
DNA-dependent DNA replication
TAS
base-excision repair, gap-filling
IDA
DNA metabolic process
TAS
protein binding
IPI
magnesium ion binding
IEA
DNA-directed DNA polymerase activity
IDA
gamma DNA-directed DNA polymerase activity
TAS
protease binding
IPI
DNA binding
IEA
delta DNA polymerase activity
TAS
206
RAE1
D - Genome Maintenance
nuclear outer membrane
TAS
cytoplasm
TAS
nuclear pore
TAS
nucleus
null
cytoskeleton
null
mitotic spindle assembly
IDA
mRNA export from nucleus
TAS
microtubule binding
ISS
RNA binding
null
231
RPL22
P - Translation
cytosolic large ribosomal subunit (sensu Eukaryota)
TAS
translation
null
translational elongation
EXP
structural constituent of ribosome
null
RNA binding
null
heparin binding
IEA
207
SFRS2
T - Transcription
nuclear speck
IDA
nucleus
IDA
mRNA processing
null
RNA splicing
TAS
protein binding
IPI
pre-mRNA splicing factor activity
null
nucleotide binding
IEA
transcription corepressor activity
NAS
RNA binding
IEA
258
CCNE1
D - Genome Maintenance
nucleoplasm
EXP
nucleus
null
cytosol
EXP
G1/S transition of mitotic cell cycle
NAS
positive regulation of transcription, DNA-dependent
NAS
androgen receptor signaling pathway
NAS
cell division
IEA
protein binding
IPI
transcription coactivator activity
NAS
androgen receptor binding
NAS
302
TOP1
D - Genome Maintenance
chromosome
IEA
nucleolus
IDA
nucleoplasm
IDA
nucleus
IDA
phosphorylation
NAS
interspecies interaction between organisms
IEA
response to drug
IEP
DNA unwinding during replication
IEA
programmed cell death
NAS
protein binding
IPI
DNA topoisomerase type I activity
TAS
chromatin binding
IDA
ATP binding
IEA
254
STK11
D - Genome Maintenance
cytoplasm
IDA
nucleus
IDA
negative regulation of cell proliferation
IMP
cell cycle arrest
IDA
protein amino acid phosphorylation
IDA
regulation of fatty acid oxidation
EXP
protein binding
IPI
manganese ion binding
IEA
magnesium ion binding
IDA
protein serine/threonine kinase activity
null
ATP binding
IDA
206
PER1
C - Cellular Fate and Organization
cytoplasm
IEA
nucleus
IEA
signal transduction
IEA
regulation of transcription, DNA-dependent
IEA
entrainment of circadian clock
TAS
circadian rhythm
TAS
negative regulation of transcription
ISS
transcription
IEA
protein binding
ISS
signal transducer activity
IEA
206
FBXO11
F - Protein Fate
cytoplasm
IDA
ubiquitin ligase complex
NAS
nucleus
IDA
ubiquitin-dependent protein catabolic process
NAS
protein ubiquitination
NAS
protein binding
IPI
ubiquitin-protein ligase activity
NAS
zinc ion binding
IEA
peptidyl-arginine C-methyltransferase activity
IDA
histone-arginine N-methyltransferase activity
IDA
206
PDGFRA
D - Genome Maintenance
integral to plasma membrane
null
vascular endothelial growth factor receptor signaling pathway
IEA
positive regulation of cell migration
IDA
protein amino acid autophosphorylation
IDA
cell proliferation
null
positive regulation of DNA replication
IDA
peptidyl-tyrosine phosphorylation
IDA
platelet-derived growth factor receptor signaling pathway
IDA
positive regulation of fibroblast proliferation
IDA
cell activation
TAS
cell surface receptor linked signal transduction
null
platelet-derived growth factor alpha-receptor activity
TAS
protein heterodimerization activity
IDA
platelet-derived growth factor binding
IPI
vascular endothelial growth factor receptor activity
IDA
platelet-derived growth factor receptor binding
IPI
ATP binding
IEA
protein homodimerization activity
IDA
626
STUB1
C - Cellular Fate and Organization
ubiquitin conjugating enzyme complex
TAS
cytoplasm
IDA
ubiquitin ligase complex
IEA
nuclear inclusion body
IDA
protein polyubiquitination
IDA
protein maturation
TAS
protein folding
TAS
positive regulation of protein ubiquitination
IDA
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
IDA
misfolded or incompletely synthesized protein catabolic process
IDA
proteasomal ubiquitin-dependent protein catabolic process
IDA
ubiquitin-dependent SMAD protein catabolic process
IDA
regulation of glucocorticoid metabolic process
IDA
misfolded protein binding
IDA
ubiquitin-protein ligase activity
TAS
TPR domain binding
IDA
Hsp90 protein binding
IDA
Hsp70 protein binding
IDA
SMAD binding
IDA
kinase binding
IPI
protein binding, bridging
TAS
protein homodimerization activity
ISS
219
NUP214
A - Transport and Sensing
nuclear pore
null
cytosol
EXP
protein export from nucleus
IMP
mRNA transport
IEA
protein binding
IPI
transporter activity
TAS
232
CDKN2A
D - Genome Maintenance
protein complex
IDA
nucleolus
IDA
nucleoplasm
IDA
somatic stem cell division
ISS
caspase activation
IMP
rRNA processing
IEA
protein stabilization
IDA
negative regulation of B cell proliferation
ISS
induction of apoptosis
IMP
protein destabilization
IDA
senescence (sensu Magnoliophyta)
IMP
cell cycle
NAS
apoptotic mitochondrial changes
IMP
DNA fragmentation during apoptosis
IMP
positive regulation of DNA damage response, signal transduction by p53 class mediator
IDA
negative regulation of ubiquitin ligase activity
ISS
cell cycle arrest
IMP
regulation of protein export from nucleus
IMP
protein binding
IPI
p53 binding
IPI
kinase activity
null
206
BRIP1
D - Genome Maintenance
cytoplasm
IDA
nucleus
NAS
DNA repair
null
regulation of transcription from RNA polymerase II promoter
IDA
DNA damage checkpoint
NAS
double-strand break repair
NAS
protein binding
IPI
ATP-dependent DNA helicase activity
NAS
ATP binding
IEA
DNA binding
NAS
216
TP63
T - Transcription
cytoplasm
IDA
nucleus
null
positive regulation of Notch signaling pathway
IDA
regulation of transcription, DNA-dependent
null
negative regulation of cell growth
IEA
Notch signaling pathway
IEA
protein homotetramerization
IPI
response to tumor cell
IEA
apoptosis
IDA
induction of apoptosis
TAS
positive regulation of transcription, DNA-dependent
IDA
negative regulation of transcription, DNA-dependent
IDA
transcription
IEA
transcriptional repressor activity
IDA
transcription factor activity
null
transcriptional activator activity
IDA
zinc ion binding
IEA
DNA binding
NAS
identical protein binding
IPI
216
NCOA2
T - Transcription
nucleus
null
regulation of transcription, DNA-dependent
null
transcription
IEA
protein binding
IPI
transcription coactivator activity
null
nuclear hormone receptor binding
IEA
206
NOS3
C - Cellular Fate and Organization
cytoplasm
null
Golgi membrane
EXP
caveola
IDA
cytoskeleton
IEA
cytosol
EXP
response to heat
NAS
cell motility
TAS
anti-apoptosis
ISS
positive regulation of angiogenesis
ISS
nitric oxide biosynthetic process
IDA
regulation of blood vessel size
NAS
endothelial cell migration
IMP
blood vessel remodeling
ISS
positive regulation of vasodilation
NAS
positive regulation of guanylate cyclase activity
IMP
mitochondrion organization and biogenesis
ISS
arginine catabolic process
IDA
NADP binding
NAS
protein binding
IPI
actin monomer binding
IPI
calmodulin binding
IEA
nitric-oxide synthase activity
TAS
FMN binding
NAS
FAD binding
NAS
calcium ion binding
IEA
zinc ion binding
IEA
cadmium ion binding
NAS
heme binding
IDA
206
PPM1D
D - Genome Maintenance
protein serine/threonine phosphatase complex
IEA
nucleus
null
response to radiation
TAS
protein amino acid dephosphorylation
null
negative regulation of cell proliferation
null
regulation of progression through cell cycle
null
protein binding
IPI
magnesium ion binding
IEA
manganese ion binding
IEA
protein phosphatase type 2C activity
TAS
protein serine/threonine phosphatase activity
TAS
0
NEIL1
D - Genome Maintenance
cytoplasm
IDA
nucleus
IDA
DNA repair
null
base-excision repair
IDA
nucleotide-excision repair
IEA
response to oxidative stress
IDA
negative regulation of nuclease activity
IDA
damaged DNA binding
IEA
DNA-(apurinic or apyrimidinic site) lyase activity
IEA
zinc ion binding
IEA
protein C-terminus binding
IPI
207
WT1
C - Cellular Fate and Organization
cytoplasm
IEA
nuclear speck
IDA
nucleoplasm
IDA
nucleus
null
negative regulation of protein biosynthetic process
IDA
negative regulation of apoptosis
IGI
negative regulation of cell growth
IDA
regulation of transcription, DNA-dependent
null
ureteric bud branching
IGI
negative regulation of cell proliferation
IDA
adrenal gland development
IMP
induction of apoptosis
IDA
negative regulation of transcription from RNA polymerase II promoter
IDA
glomerular basement membrane development
IMP
sex determination
IDA
transcription
IEA
positive regulation of gene-specific transcription
IDA
heart development
IMP
transcriptional repressor activity
IDA
specific transcriptional repressor activity
IDA
transcription factor activity
null
RNA binding
IEA
transcriptional activator activity
IDA
zinc ion binding
IDA
216
NFKB2
C - Cellular Fate and Organization
cytoplasm
IDA
nucleoplasm
EXP
nucleus
IDA
cytosol
EXP
signal transduction
IEA
regulation of transcription, DNA-dependent
IDA
transcription
IEA
protein binding
IPI
transcription factor activity
TAS
transcription coactivator activity
TAS
214
NONO
D - Genome Maintenance
paraspeckles
IDA
nucleus
null
nuclear matrix
IDA
mRNA processing
TAS
RNA splicing
null
DNA repair
IEA
DNA recombination
IEA
regulation of transcription
IEA
transcription
IEA
protein binding
IPI
pre-mRNA splicing factor activity
null
nucleotide binding
IEA
RNA binding
IEA
DNA binding
IEA
identical protein binding
IPI
206
KDSR
N - Not Matched
endoplasmic reticulum membrane
EXP
integral to membrane
IEA
extracellular space
null
3-keto-sphinganine metabolic process
IDA
3-dehydrosphinganine reductase activity
IDA
binding
IEA
214
PDGFRB
C - Cellular Fate and Organization
integral to plasma membrane
IEA
signal transduction
TAS
vascular endothelial growth factor receptor signaling pathway
IEA
positive regulation of cell proliferation
IDA
positive regulation of cell migration
IDA
protein amino acid autophosphorylation
IDA
peptidyl-tyrosine phosphorylation
IDA
platelet-derived growth factor receptor signaling pathway
IDA
protein binding
IPI
platelet-derived growth factor beta-receptor activity
IDA
platelet activating factor receptor activity
TAS
platelet-derived growth factor binding
IPI
vascular endothelial growth factor receptor activity
IEA
platelet-derived growth factor receptor binding
IPI
ATP binding
IEA
platelet-derived growth factor receptor activity
TAS
206
FGFR3
C - Cellular Fate and Organization
integral to plasma membrane
null
skeletal development
null
positive regulation of cell proliferation
IGI
MAPKKK cascade
TAS
fibroblast growth factor receptor signaling pathway
TAS
cell growth
null
protein amino acid phosphorylation
IEA
JAK-STAT cascade
TAS
fibroblast growth factor receptor activity
NAS
fibroblast growth factor binding
IPI
ATP binding
IEA
identical protein binding
IPI
279
ATR
D - Genome Maintenance
nucleoplasm
EXP
DNA replication
EXP
senescence (sensu Magnoliophyta)
IDA
cell cycle
null
DNA repair
TAS
positive regulation of DNA damage response, signal transduction by p53 class mediator
IMP
cell cycle checkpoint
TAS
multicellular organismal development
TAS
DNA damage checkpoint
IDA
negative regulation of DNA replication
IMP
protein binding
IPI
MutSalpha complex binding
IDA
protein kinase activity
TAS
manganese ion binding
IEA
MutLalpha complex binding
IDA
protein serine/threonine kinase activity
IDA
DNA binding
IEA
ATP binding
IEA
273
SOCS1
C - Cellular Fate and Organization
cytoplasm
null
negative regulation of tyrosine phosphorylation of Stat3 protein
ISS
modification-dependent protein catabolic process
IEA
negative regulation of insulin receptor signaling pathway
ISS
cytokine and chemokine mediated signaling pathway
ISS
regulation of protein amino acid phosphorylation
ISS
JAK-STAT cascade
null
regulation of growth
IEA
negative regulation of JAK-STAT cascade
NAS
protein kinase binding
null
insulin-like growth factor receptor binding
null
protein kinase inhibitor activity
TAS
229
DDX5
T - Transcription
nucleolus
IEA
spliceosome
IEA
nucleus
null
RNA splicing
IEA
mRNA processing
IEA
cell growth
null
ATP-dependent helicase activity
IEA
RNA helicase activity
NAS
RNA binding
IEA
ATP binding
IEA
424
CDH1
T - Transcription
apical junction complex
IDA
perinuclear region
IDA
Golgi apparatus
IDA
cell-cell adherens junction
IDA
catenin complex
IDA
integral to membrane
null
actin cytoskeleton
IDA
focal adhesion
IDA
lateral plasma membrane
IDA
homophilic cell adhesion
NAS
positive regulation of transcription factor import into nucleus
IDA
protein binding
IPI
calcium ion binding
IEA
transcriptional activator activity
IDA
cell adhesion molecule binding
NAS
206
PROP1
T - Transcription
central nervous system development
null
sequence-specific DNA binding
IEA
transcription factor activity
IEA
RNA polymerase II transcription factor activity
null
207
CREB1
C - Cellular Fate and Organization
nucleus
null
signal transduction
null
response to organic substance
IDA
interspecies interaction between organisms
IEA
protein amino acid phosphorylation
IDA
transcription, DNA-dependent
TAS
sequence-specific DNA binding
IEA
protein binding
IPI
transcription cofactor activity
null
transcription factor activity
null
protein dimerization activity
IEA
411
GNAS
M - Other Metabolism
plasma membrane
IEA
signal transducer activity
IEA
GTP binding
IEA
213
PMS2
D - Genome Maintenance
nucleus
null
mismatch repair
IDA
protein binding
IPI
endonuclease activity
IEA
single base insertion or deletion binding
IDA
ATP binding
IEA
DNA binding
null
212
PMS1
D - Genome Maintenance
nucleus
null
mismatch repair
null
mismatched DNA binding
IEA
DNA binding
null
ATP binding
IEA
737
CREBBP
C - Cellular Fate and Organization
nuclear body
IDA
cytoplasm
null
nucleus
null
signal transduction
NAS
response to hypoxia
TAS
regulation of transcription, DNA-dependent
null
positive regulation of transcription
IDA
protein complex assembly
TAS
histone acetylation
IDA
interspecies interaction between organisms
IEA
homeostatic process
NAS
N-terminal peptidyl-lysine acetylation
IDA
transcription
IEA
protein binding
IPI
p53 binding
IPI
MyoD binding
IDA
transcription factor activity
TAS
transcription coactivator activity
IDA
acetyltransferase activity
IDA
zinc ion binding
IEA
signal transducer activity
null
histone acetyltransferase activity
IDA
232
CDK4
D - Genome Maintenance
cyclin-dependent protein kinase holoenzyme complex
IDA
nucleus
IDA
cytosol
EXP
G1/S transition of mitotic cell cycle
null
cell proliferation
null
protein amino acid phosphorylation
IDA
positive regulation of fibroblast proliferation
IMP
regulation of progression through cell cycle
null
cell division
IEA
protein binding
IPI
ATP binding
IEA
cyclin-dependent protein kinase activity
TAS
218
NDRG1
N - Not Matched
cytoplasm
IDA
plasma membrane
IEA
nucleus
IEA
cytoskeleton
IDA
response to metal ion
TAS
protein binding
IPI
217
CYLD
D - Genome Maintenance
perinuclear region
IEA
ribosome
IEA
cytoskeleton
NAS
ubiquitin-dependent protein catabolic process
NAS
cell cycle
IEA
translation
IEA
structural constituent of ribosome
IEA
cysteine-type peptidase activity
IEA
ubiquitin thiolesterase activity
NAS
212
GH1
C - Cellular Fate and Organization
extracellular space
IDA
signal transduction
null
glucose transport
IDA
positive regulation of insulin-like growth factor receptor signaling pathway
IDA
positive regulation of MAPK activity
TAS
positive regulation of tyrosine phosphorylation of Stat3 protein
IDA
positive regulation of tyrosine phosphorylation of Stat5 protein
IDA
positive regulation of phosphoinositide 3-kinase cascade
IDA
positive regulation of body size
IDA
response to estradiol stimulus
IDA
JAK-STAT cascade
IDA
protein binding
IPI
prolactin receptor binding
IPI
hormone activity
TAS
growth hormone receptor binding
IPI
growth factor activity
IPI
411
CHIC2
N - Not Matched
plasma membrane
IEA
protein binding
IPI
206
ERCC2
D - Genome Maintenance
nucleus
null
transcription factor TFIIH complex
IDA
hair cell differentiation
IMP
UV protection
IGI
RNA elongation from RNA polymerase II promoter
EXP
transcription initiation from RNA polymerase II promoter
EXP
transcription from RNA polymerase II promoter
TAS
induction of apoptosis
IMP
transcription-coupled nucleotide-excision repair
IDA
positive regulation of transcription from RNA polymerase II promoter
IDA
interspecies interaction between organisms
IEA
cell cycle checkpoint
IMP
nucleotide-excision repair
null
nucleotide-excision repair, DNA damage removal
EXP
response to oxidative stress
IMP
protein binding
IPI
protein N-terminus binding
IPI
ATP-dependent DNA helicase activity
null
magnesium ion binding
IEA
iron-sulfur cluster binding
IEA
iron ion binding
IEA
5' to 3' DNA helicase activity
IDA
protein C-terminus binding
IPI
ATP binding
IEA
DNA binding
IEA
DNA-dependent ATPase activity
TAS
274
PTPN11
C - Cellular Fate and Organization
cytosol
EXP
signal transduction
null
protein amino acid dephosphorylation
IEA
protein binding
IPI
non-membrane spanning protein tyrosine phosphatase activity
TAS
206
SLC25A4
A - Transport and Sensing
mitochondrion
null
integral to plasma membrane
null
mitochondrial inner membrane
EXP
interspecies interaction between organisms
IEA
transport
TAS
generation of precursor metabolites and energy
TAS
mitochondrial genome maintenance
TAS
protein binding
IPI
adenine transporter activity
TAS
244
PAWR
C - Cellular Fate and Organization
cytoplasm
NAS
plasma membrane
IDA
nucleus
NAS
positive regulation of apoptosis
NAS
negative regulation of cell proliferation
TAS
apoptosis
TAS
negative regulation of transcription from RNA polymerase II promoter
TAS
transcription
IEA
leucine zipper domain binding
IPI
transcription corepressor activity
TAS
enzyme binding
IDA
209
XPA
D - Genome Maintenance
nucleoplasm
EXP
nucleus
null
DNA repair
TAS
nucleotide-excision repair, DNA damage removal
EXP
protein binding
null
damaged DNA binding
TAS
nucleotide binding
IEA
protein domain specific binding
IPI
zinc ion binding
IEA
protein homodimerization activity
IPI
248
FGFR1
C - Cellular Fate and Organization
integral to plasma membrane
null
membrane fraction
NAS
extracellular region
NAS
skeletal development
null
positive regulation of cell proliferation
IGI
MAPKKK cascade
null
fibroblast growth factor receptor signaling pathway
null
cell growth
NAS
protein amino acid phosphorylation
null
protein binding
IPI
fibroblast growth factor receptor activity
null
protein-tyrosine kinase activity
null
ATP binding
NAS
heparin binding
NAS
222
BIRC3
C - Cellular Fate and Organization
cytoplasm
IDA
nucleus
IDA
apoptosis
IEA
anti-apoptosis
null
cell surface receptor linked signal transduction
null
protein binding
null
ubiquitin-protein ligase activity
IDA
zinc ion binding
IEA
255
DDIT3
D - Genome Maintenance
nucleus
IEA
regulation of transcription, DNA-dependent
null
mRNA transcription from RNA polymerase II promoter
IDA
cell redox homeostasis
IDA
cell cycle arrest
IEA
regulation of transcription in response to stress
TAS
regulation of cell redox homeostasis
IDA
response to DNA damage stimulus
TAS
regulation of progression through cell cycle
NAS
sequence-specific DNA binding
IEA
transcription factor activity
NAS
transcription corepressor activity
null
protein dimerization activity
IEA
247
FUS
T - Transcription
nucleus
null
RNA splicing
EXP
cell death
IEA
protein binding
IPI
RNA binding
null
zinc ion binding
IEA
DNA binding
IEA
328
SMAD4
C - Cellular Fate and Organization
transcription factor complex
IPI
nucleus
null
activin responsive factor complex
IDA
cytosol
EXP
SMAD protein complex assembly
TAS
response to hypoxia
IMP
negative regulation of cell growth
IDA
palate development
ISS
transforming growth factor beta receptor signaling pathway
IDA
BMP signaling pathway
IDA
negative regulation of transcription, DNA-dependent
IDA
positive regulation of transforming growth factor beta receptor signaling pathway
IDA
transcription
IEA
protein binding
IPI
transcription cofactor activity
TAS
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
IDA
transcription factor activity
null
protein homodimerization activity
IPI
351
HSP90AA1
C - Cellular Fate and Organization
melanosome
IEA
cytoplasm
null
cytosol
NAS
response to unfolded protein
NAS
protein refolding
TAS
signal transduction
NAS
mitochondrial transport
TAS
positive regulation of nitric oxide biosynthetic process
ISS
TPR domain binding
IDA
heat shock protein activity
null
nucleotide binding
TAS
unfolded protein binding
IEA
nitric-oxide synthase regulator activity
ISS
ATP binding
TAS
protein homodimerization activity
TAS
239
SET
D - Genome Maintenance
perinuclear region
IDA
endoplasmic reticulum
IDA
nucleus
IDA
nucleoplasm
IEA
cytosol
IEA
DNA replication
TAS
nucleosome assembly
null
nucleosome disassembly
TAS
negative regulation of histone acetylation
TAS
nucleocytoplasmic transport
NAS
histone binding
TAS
protein phosphatase inhibitor activity
TAS
protein phosphatase type 2A regulator activity
TAS
376
JUN
C - Cellular Fate and Organization
nuclear chromosome
TAS
cytosol
EXP
SMAD protein nuclear translocation
IDA
transforming growth factor beta receptor signaling pathway
IDA
transcription
IEA
protein binding
IPI
transcription factor activity
null
RNA polymerase II transcription factor activity
null
protein dimerization activity
IEA
Rho GTPase activator activity
IDA
transcription factor binding
IPI
211
TCF7L2
D - Genome Maintenance
nucleus
NAS
positive regulation of protein kinase B signaling cascade
IMP
blood vessel development
IMP
regulation of transcription from RNA polymerase II promoter
TAS
regulation of Wnt receptor signaling pathway
NAS
regulation of hormone metabolic process
IDA
cell proliferation
IMP
establishment and/or maintenance of chromatin architecture
NAS
anti-apoptosis
IDA
glucose homeostasis
IDA
negative regulation of transcription factor activity
IDA
positive regulation of protein binding
IDA
transcription
IEA
response to glucose stimulus
ISS
positive regulation of protein export from nucleus
IMP
signal transduction
TAS
pancreas development
TAS
fat cell differentiation
IDA
positive regulation of insulin secretion
IDA
cell cycle arrest
IMP
regulation of progression through cell cycle
TAS
myoblast cell fate commitment
IDA
protein binding
IPI
sequence-specific DNA binding
IDA
specific transcriptional repressor activity
IDA
transcription factor activity
NAS
beta-catenin binding
IDA
protein kinase binding
IPI
gamma-catenin binding
IPI
RNA polymerase II transcription factor activity
IDA
nuclear hormone receptor binding
IPI
transcription factor binding
IPI
206
IGF1
D - Genome Maintenance
platelet alpha granule lumen
EXP
insulin-like growth factor binding protein complex
IC
positive regulation of cell proliferation
null
cell motility
null
positive regulation of tyrosine phosphorylation of Stat5 protein
IDA
positive regulation of Ras protein signal transduction
IDA
Ras protein signal transduction
null
positive regulation of fibroblast proliferation
IDA
positive regulation of gene-specific transcription
IDA
regulation of body size
IEP
myoblast differentiation
IDA
positive regulation of glycolysis
IDA
positive regulation of epithelial cell proliferation
IDA
phosphoinositide-mediated signaling
IDA
positive regulation of DNA replication
IDA
positive regulation of mitosis
IDA
anti-apoptosis
IDA
positive regulation of phosphoinositide 3-kinase cascade
IDA
positive regulation of smooth muscle cell proliferation
IDA
DNA replication
null
signal transduction
null
skeletal development
null
muscle development
TAS
glycolate metabolic process
TAS
positive regulation of insulin-like growth factor receptor signaling pathway
IDA
myoblast proliferation
IDA
hormone activity
null
insulin-like growth factor receptor binding
null
insulin receptor binding
IPI
growth factor activity
IEA
0
HTR1B
A - Transport and Sensing
integral to plasma membrane
TAS
G-protein signaling, coupled to cyclic nucleotide second messenger
TAS
synaptic transmission
TAS
protein binding
IPI
serotonin receptor activity
TAS
208
COL1A1
C - Cellular Fate and Organization
plasma membrane
EXP
collagen type I
IMP
skeletal development
null
blood vessel development
IMP
epidermis development
TAS
sensory perception of sound
IMP
collagen fibril organization
IMP
embryonic skeletal development
IMP
skin morphogenesis
IMP
visual perception
IMP
protein binding
IPI
platelet-derived growth factor binding
IDA
identical protein binding
IDA
97
JonesErbB1
MINT
81
BIND_Fly
BioGrid_Fly
FlyEmbryo
30
HPRD
BioGrid
MINT
30
INNATEDB
18
HPRD
1
BIND_Mouse
HPRD
63
HPRD
6
IntAct_Mouse
IntAct
32
BioGrid
410
BioGrid_Fly
4
HPRD
BioGrid
41
INNATEDB_Mouse
49
HPRD
IntAct
BIND
BioGrid
84
BioGrid
2
JonesErbB1
MINT
34
HPRD
72
BioGrid_Yeast
YeastLow
IntAct_Yeast
82
INNATEDB
Miller_WntLumier
164
HPRD
BIND
BioGrid
MINT
9
BioGrid_Yeast
YeastLow
5
HPRD
BioGrid_Mouse
BioGrid
37
INNATEDB
HPRD
BIND
47
Jorgensen_EphR
15
INNATEDB
206
HPRD
BioGrid
49
INNATEDB_Mouse
38
INNATEDB
BioGrid
4
JonesErbB1
HPRD
BioGrid
64
HPRD
BioGrid
39
HPRD
26
INNATEDB_Mouse
274
HPRD
50
IntAct
20
HPRD
28
IntAct_Worm
MINT_Worm
BIND_Worm
CORE_1
BioGrid_Worm
41
HPRD
24
HPRD
IntAct
BIND
BioGrid
38
HPRD
90
BioGrid
36
HPRD
BioGrid
43
HPRD
6
HPRD
BioGrid
51
Yu_GoldStd
BIND_Yeast
INTEROLOG
BioGrid_Yeast
MIPS
20
BEHRENDS_AUTOPHAGY_LOW
15
INNATEDB
143
INNATEDB
HPRD
5
HPRD
BioGrid
28
YeastHigh
BioGrid_Yeast
IntAct_Yeast
7
HPRD
IntAct
BIND
BioGrid
198
BIND
BioGrid
59
HPRD
IntAct
BIND
BioGrid
106
HPRD
21
BIND_Mouse
INNATEDB
HPRD
BioGrid
2
INNATEDB
HPRD
11
INNATEDB
BioGrid
44
BIND_Mouse
HPRD
60
HPRD
BioGrid
14
INNATEDB_Mouse
HPRD
126
HPRD
BIND
IntAct
BioGrid
MINT
16
IntAct
20
BIND
13
HPRD
BioGrid
BIND
4
HPRD
BioGrid
11
IntAct_Worm
MINT_Worm
BIND_Worm
TewariTGFb
BioGrid_Worm
36
INNATEDB_Mouse
INNATEDB
28
HPRD
IntAct
BioGrid
23
MINT_Yeast
BioGrid_Yeast
YeastLow
IntAct_Yeast
5
INNATEDB_Mouse
BioGrid_Rat
10
MINT_Mouse
MINT
63
HPRD
27
IntAct
30
HPRD
IntAct
BIND
BioGrid
MINT
12
BEHRENDS_AUTOPHAGY_LOW
34
HPRD
206
HPRD
IntAct
25
INNATEDB
INNATEDB_Mouse
HPRD
31
HPRD
BioGrid
73
HPRD
BIND
51
IntAct
2
BEHRENDS_AUTOPHAGY_LOW
4
IntAct
71
YeastLow
IntAct_Yeast
28
IntAct
39
INNATEDB
HPRD
MINT
155
BioGrid
5
HPRD
BioGrid
25
HPRD
MINT
6
HPRD
35
MINT_Mouse
BioGrid
IntAct
51
BEHRENDS_AUTOPHAGY_LOW
BioGrid
61
HPRD
56
HPRD
BIND
BioGrid
153
Jorgensen_EphR
14
BIND_Worm
INTEROLOG
76
MINT_Mouse
109
IntAct
BioGrid
BIND
68
HPRD
BioGrid
14
IntAct
77
HPRD
BioGrid
12
BioGrid
63
HPRD
IntAct
MINT
350
INNATEDB_Mouse
BIND_Mouse
HPRD
IntAct
BIND
BioGrid
Jorgensen_EphR
MINT
86
INNATEDB_Mouse
BioGrid
99
HPRD
82
INNATEDB
139
StelzlHigh
HPRD
IntAct
BioGrid
MINT
60
IntAct
5
HPRD
55
INNATEDB
44
INNATEDB
65
INNATEDB
29
HPRD
IntAct_Mouse
IntAct
BIND
BioGrid
MINT
56
HPRD
IntAct_Mouse
BioGrid
IntAct
3
HPRD
1
BioGrid
32
HPRD
BIND
BioGrid
82
Jorgensen_EphR
212
HPRD
21
BioGrid
24
HPRD
BioGrid
17
HPRD
BIND
BioGrid
95
HPRD
BIND
BioGrid
228
YeastLow
73
BioGrid
VidalHuman_non_core
7
INNATEDB
HPRD
BioGrid
21
BioGrid
26
INNATEDB
23
INNATEDB
HPRD
BioGrid
36
MINT_Rat
HPRD
BioGrid
5
IntAct
206
BioGrid_Mouse
81
HPRD
IntAct
29
IntAct
MINT
19
IntAct
28
INNATEDB
50
INNATEDB
65
INNATEDB
IntAct
BioGrid
MINT
11
Yu_GoldStd
YeastHigh
BIND_Worm
MINT_Yeast
Krogan_Core
INTEROLOG
BioGrid
BIND
BioGrid_Worm
MIPS
CE_DATA
IntAct_Worm
HPRD
MINT_Worm
BioGrid_Yeast
IntAct
IntAct_Yeast
282
HPRD
83
HPRD
15
BEHRENDS_AUTOPHAGY_LOW
25
HPRD
IntAct_Mouse
BioGrid
13
HPRD
BIND
IntAct
BioGrid
MINT
104
HPRD
18
HPRD
151
IntAct
59
HPRD
BioGrid
66
BioGrid
4
BEHRENDS_AUTOPHAGY_LOW
26
HPRD
15
Krogan_NonCore
81
HPRD
20
HPRD
32
HPRD
MINT
40
INNATEDB
8
HPRD
257
IntAct_Mouse
206
IntAct_Mouse
27
HPRD
BIND
BioGrid
47
HPRD
BioGrid
MINT
19
BioGrid
59
BioGrid
16
IntAct
38
MGI
HPRD
BioGrid
IntAct
26
IntAct
18
HPRD
BioGrid
4
HPRD
IntAct
BioGrid
MINT
46
IntAct
42
HPRD
IntAct_Mouse
BioGrid
IntAct
MINT
22
HPRD
40
HPRD
BioGrid
44
MGI
BIND_Mouse
HPRD
IntAct_Mouse
MINT_Mouse
IntAct
BIND
BioGrid
MINT
IntAct_Rat
90
BIND
67
HPRD
BioGrid_Mouse
MINT_Mouse
IntAct
BioGrid
MINT
21
HPRD
14
BIND
10
BEHRENDS_AUTOPHAGY_LOW
51
HPRD
9
BIND
11
HPRD
BIND
BioGrid
MINT
85
HPRD
21
HPRD
BioGrid
76
BioGrid_Yeast
30
BioGrid_Yeast
14
YeastMedium
62
HPRD
BioGrid
12
HPRD
IntAct
BioGrid
95
INNATEDB
2
HPRD
BIND
BioGrid
IntAct
25
BIND_Mouse
INNATEDB_Mouse
INNATEDB
HPRD
BioGrid
113
HPRD
IntAct
BioGrid
1
HPRD
BioGrid
47
IntAct
90
HPRD
BioGrid
89
HPRD
129
HPRD
BIND
BioGrid
33
INNATEDB
HPRD
BioGrid
23
BioGrid
IntAct
94
INNATEDB
39
BioGrid_Yeast
6
IntAct
23
HPRD
IntAct
BioGrid
31
HPRD
105
HPRD
IntAct
BioGrid
13
MINT
410
BioGrid
10
IntAct_Worm
MINT_Worm
BIND_Worm
CORE_1
BioGrid_Worm
90
HPRD
BIND
BioGrid
10
HPRD
BioGrid
29
HPRD
IntAct_Mouse
IntAct
BIND
BioGrid
MINT
68
HPRD
IntAct
BioGrid
31
BEHRENDS_AUTOPHAGY_LOW
33
HPRD
BIND
4
BioGrid
MINT
20
INNATEDB
JonesErbB1
HPRD
BIND
BioGrid
MINT
120
IntAct
135
BioGrid
67
HPRD
BioGrid
181
HPRD
BioGrid
MINT
33
BEHRENDS_AUTOPHAGY_LOW
35
JonesErbB1
MINT
206
IntAct
195
INNATEDB
3
HPRD
IntAct
BioGrid
20
HPRD
BioGrid
5
MGI
HPRD
9
IntAct
BIND
142
Blagoev
HPRD
BioGrid
IntAct
BIND
Moran_EGFR
I2D-c
MINT
151
INNATEDB_Mouse
INNATEDB
30
HPRD
BioGrid
9
HPRD
BioGrid
14
IntAct
BioGrid
11
IntAct
51
INNATEDB
HPRD
5
BIND_Fly
FlyEmbryo
IntAct_Fly
58
BioGrid
96
INNATEDB
39
HPRD
11
INNATEDB_Mouse
52
HPRD
BioGrid
33
BEHRENDS_AUTOPHAGY_LOW
18
BEHRENDS_AUTOPHAGY_LOW
9
HPRD
BioGrid
16
INNATEDB
37
MGI
HPRD
BioGrid_Mouse
BIND
IntAct
BioGrid
MINT
18
MINT
148
HPRD
BioGrid
72
HPRD
27
HPRD
98
BIND_Mouse
INNATEDB_Mouse
HPRD
BioGrid
201
MYTH_EGFR
BioGrid
29
INNATEDB
47
BioGrid
25
HPRD
115
HPRD
24
HPRD
MINT
17
HPRD
BioGrid
24
IntAct
BIND
MINT
48
HPRD
MINT
7
BEHRENDS_AUTOPHAGY_LOW
55
BIND_Mouse
HPRD
IntAct
9
BIND_Mouse
HPRD
BioGrid
186
HPRD
BIND
BioGrid
MINT
42
HPRD
BioGrid
MINT
28
HPRD
42
HPRD
14
HPRD
BIND
BioGrid
15
INNATEDB
49
HPRD
MINT
63
Blagoev
49
HPRD
JonesErbB1
BioGrid
40
HPRD
BioGrid
206
IntAct_Mouse
73
HPRD
6
HPRD
20
HPRD
81
IntAct_Mouse
11
INNATEDB
IntAct
21
IntAct
120
INNATEDB
HPRD
JonesErbB1
BioGrid
MINT
10
HPRD
21
HPRD
SOURAV_MAPK_LOW
167
HPRD
262
MYTH_EGFR
IntAct
199
INNATEDB
2
JonesErbB1
MINT
206
HPRD
BioGrid
19
HPRD
116
HPRD
BioGrid
60
IntAct
63
SOURAV_MAPK_HIGH
47
INNATEDB
5
HPRD
139
SOURAV_MAPK_LOW
56
INNATEDB
6
INNATEDB
HPRD
BioGrid
13
INNATEDB
HPRD
BioGrid
11
IntAct
31
BioGrid
7
HPRD
BioGrid
11
BioGrid
20
Blagoev
JonesErbB1
HPRD
BIND
Moran_EGFR
MINT
17
Yu_GoldStd
BIND_Yeast
BioGrid_Yeast
BioGrid
MIPS
177
INNATEDB
29
HPRD
IntAct_Mouse
BIND
IntAct
BioGrid
MINT
20
INNATEDB
89
INNATEDB_Mouse
Blagoev
JonesErbB1
HPRD
IntAct
BioGrid
BIND
MINT
5
INNATEDB_Mouse
HPRD
BioGrid
11
HPRD
BIND
IntAct
BioGrid
118
INNATEDB_Mouse
INNATEDB
BIND_Mouse
HPRD
IntAct_Mouse
BioGrid_Mouse
IntAct
BIND
BioGrid
MINT
63
HPRD
BioGrid
20
IntAct
BioGrid
18
IntAct_Mouse
IntAct
25
BioGrid
110
INNATEDB
60
HPRD
7
HPRD
BioGrid
2
BEHRENDS_AUTOPHAGY_LOW
40
HPRD
IntAct
BioGrid
MINT
IntAct_Rat
MINT_Fly
IntAct_Fly
119
INNATEDB_Mouse
HPRD
BioGrid
27
MINT
28
HPRD
BIND
BioGrid
89
HPRD
BioGrid
31
HPRD
85
HPRD
IntAct
BioGrid
MINT
92
INNATEDB
HPRD
70
INNATEDB
HPRD
BioGrid
22
BioGrid
95
HPRD
IntAct
BIND
MINT
2
HPRD
BIND
BioGrid
30
MINT_Mouse
108
HPRD
11
HPRD
BIND
BioGrid
344
INNATEDB_Mouse
IntAct_Mouse
85
INNATEDB
HPRD
BioGrid
66
IntAct
12
HPRD
79
IntAct
MINT
34
BEHRENDS_AUTOPHAGY_LOW
165
Jorgensen_EphR
SOURAV_MAPK_LOW
78
HPRD
VidalHuman_core
BioGrid
IntAct
MINT
52
HPRD
BIND
87
INNATEDB
HPRD
BIND
BioGrid
MINT
79
IntAct
7
HPRD
7
HPRD
BioGrid
25
HPRD
72
INNATEDB
9
HPRD
50
HPRD
25
BioGrid
169
BioGrid
119
INNATEDB
30
BioGrid
10
HPRD
BioGrid
49
INNATEDB_Mouse
124
HPRD
BioGrid
9
INNATEDB_Mouse
43
HPRD
BIND
BioGrid
87
HPRD
MINT
12
HPRD
BioGrid
206
BioGrid
18
BioGrid
50
BIND_Mouse
HPRD
BIND
130
HPRD
BioGrid
MINT
7
BEHRENDS_AUTOPHAGY_LOW
24
HPRD
BIND
BioGrid
IntAct
121
INNATEDB
41
HPRD
BioGrid
11
HPRD
24
HPRD
BioGrid
31
HPRD
BioGrid
19
JonesErbB1
MINT
28
HPRD
18
BEHRENDS_AUTOPHAGY_LOW
45
HPRD
IntAct
BioGrid
MINT
49
INNATEDB
HPRD
IntAct_Mouse
IntAct
BIND
BioGrid
SOURAV_MAPK_LOW
MINT
128
INNATEDB
BioGrid
BioGrid_Yeast
64
HPRD
BIND
BioGrid
MINT
93
MINT
81
MINT
96
BioGrid
197
BioGrid
34
YeastLow
44
INNATEDB
11
IntAct_Mouse
MINT_Mouse
39
HPRD
BioGrid
29
HPRD
IntAct_Mouse
IntAct
BioGrid
MINT
22
YeastLow
11
HPRD
46
HPRD
BioGrid
41
HPRD
BioGrid
26
HPRD
IntAct
36
HPRD
MINT
1
HPRD
BioGrid
6
BioGrid
4
BioGrid
206
YeastLow
26
IntAct
91
INNATEDB
HPRD
28
HPRD
BioGrid
16
INNATEDB_Mouse
INNATEDB
BIND_Mouse
HPRD
IntAct_Mouse
BioGrid
MINT
39
BioGrid_Fly
FlyEmbryo
72
INNATEDB_Mouse
4
INNATEDB
HPRD
BioGrid
192
HPRD
BioGrid
11
BioGrid
206
HPRD
4
BioGrid
72
MINT
15
HPRD
BIND
16
HPRD
51
HPRD
62
HPRD
BioGrid
84
HPRD
79
HPRD
BioGrid
50
HPRD
29
HPRD
BioGrid
63
IntAct
61
MINT_Rat
HPRD
BioGrid_Mouse
MINT_Mouse
IntAct
MINT
253
BioGrid_Yeast
29
BIND_Mouse
HPRD
BIND
BioGrid
135
IntAct
30
BioGrid
206
HPRD
VidalHuman_core
BioGrid
IntAct
MINT
52
IntAct
35
BioGrid
55
HPRD
7
INNATEDB
HPRD
MINT
27
IntAct
MINT
14
INNATEDB
15
HPRD
126
HPRD
IntAct
BioGrid
125
HPRD
BioGrid
5
HPRD
BioGrid
48
HPRD
MINT
90
INNATEDB_Mouse
INNATEDB
9
INNATEDB
BIND
18
HPRD
BIND
BioGrid
10
HPRD
BIND
62
HPRD
BIND
BioGrid
24
HPRD
MINT
36
INNATEDB
BIND_Mouse
INNATEDB_Mouse
HPRD
IntAct_Mouse
IntAct
BIND
BioGrid
MINT
124
HPRD
BioGrid
84
MGI
HPRD
BioGrid_Mouse
BioGrid
IntAct
BIND
MINT
41
HPRD
BioGrid_Yeast
BioGrid
83
MINT
14
ShawnLi
HPRD
IntAct
BioGrid
MINT
24
HPRD
45
HPRD
BIND
45
HPRD
108
HPRD
IntAct
BIND
BioGrid
10
BioGrid
63
HPRD
BioGrid
49
HPRD
41
HPRD
BioGrid_Mouse
36
BEHRENDS_AUTOPHAGY_LOW
59
Pawson4
HPRD
BioGrid
MINT
25
HPRD
BioGrid
49
HPRD
BioGrid
64
HPRD
BioGrid
77
HPRD
BioGrid
IntAct
BIND
35
HPRD
12
HPRD
IntAct
9
BIND_Mouse
HPRD
BioGrid
25
HPRD
IntAct
BIND
MINT
7
INNATEDB_Mouse
HPRD
176
INNATEDB_Mouse
INNATEDB
HPRD
103
HPRD
BioGrid
34
IntAct
83
INNATEDB_Mouse
HPRD
IntAct_Mouse
BioGrid
93
HPRD
29
HPRD
BioGrid
37
BioGrid
24
BioGrid
115
ShawnLi
IntAct
MINT
35
JonesErbB1
MINT
29
BioGrid
27
HPRD
BioGrid
24
IntAct
68
HPRD
12
HPRD
IntAct
BIND
BioGrid
49
HPRD
17
IntAct
MINT
32
INNATEDB
64
HPRD
BioGrid
MINT
4
HPRD
81
INNATEDB
19
IntAct
1
JonesErbB1
MINT
42
INNATEDB
81
HPRD
12
BioGrid
33
BEHRENDS_AUTOPHAGY_LOW
26
HPRD
72
HPRD
BioGrid
18
MINT_Mouse
BioGrid
24
BIND_Mouse
206
HPRD
IntAct
35
BioGrid
7
HPRD
24
IntAct
51
HPRD
BioGrid
93
IntAct
BioGrid
5
HPRD
34
INNATEDB
77
BioGrid
31
HPRD
92
HPRD
20
BioGrid
15
HPRD
BioGrid
35
YeastLow
6
HPRD
13
HPRD
BioGrid
MINT
15
INNATEDB_Mouse
INNATEDB
MINT_Rat
HPRD
BIND_Rat
BioGrid_Rat
MINT_Mouse
BioGrid
MINT
69
HPRD
BIND
BioGrid
11
HPRD
38
BioGrid
95
INNATEDB
158
HPRD
BioGrid
88
BioGrid
52
HPRD
BioGrid
16
HPRD
BioGrid
10
Krogan_NonCore
35
MINT
7
MGI
HPRD
27
INNATEDB_Mouse
HPRD
IntAct
44
HPRD
59
HPRD
BIND
BioGrid
129
HPRD
BIND
55
BioGrid
63
SOURAV_MAPK_HIGH
38
HPRD
BioGrid
18
IntAct
7
Jorgensen_EphR
12
HPRD
79
INNATEDB
Krogan_NonCore
10
BioGrid
178
INNATEDB
HPRD
BIND
BioGrid
134
HPRD
BioGrid
5
HPRD
BIND
BioGrid
23
INNATEDB_Mouse
INNATEDB
83
INNATEDB
19
HPRD
21
HPRD
BioGrid
83
HPRD
VidalHuman_core
BIND
BioGrid
IntAct
MINT
113
HPRD
BIND
80
BioGrid
36
INNATEDB_Mouse
19
HPRD
BioGrid
5
ShawnLi
HPRD
IntAct
BioGrid
MINT
172
HPRD
IntAct
26
HPRD
139
HPRD
21
HPRD
BioGrid
52
IntAct
42
HPRD
BioGrid
77
HPRD
IntAct
BIND
BioGrid
4
HPRD
IntAct
20
BEHRENDS_AUTOPHAGY_LOW
21
IntAct
MINT
64
SOURAV_MAPK_HIGH
171
IntAct
11
HPRD
BIND
BioGrid
21
IntAct
58
HPRD
20
INNATEDB
25
INNATEDB
19
BEHRENDS_AUTOPHAGY_LOW
3
BioGrid
YeastLow
19
YeastLow
22
MINT
25
HPRD
94
INNATEDB
HPRD
BIND
BioGrid
1
JonesErbB1
HPRD
BIND
BioGrid
MINT
87
BioGrid
92
BioGrid
206
BioGrid_Yeast
IntAct_Yeast
1
HPRD
MINT
128
HPRD
BioGrid
54
INNATEDB
HPRD
BioGrid
5
HPRD
32
HPRD
IntAct
1
BIND_Mouse
HPRD
BIND
BioGrid
23
HPRD
BioGrid
YeastLow
IntAct_Yeast
17
HPRD
BIND
BioGrid
MINT
13
HPRD
BioGrid
23
HPRD
31
HPRD
2
INNATEDB
HPRD
BIND
BioGrid
MINT
48
StelzlHigh
HPRD
IntAct
BioGrid
20
BEHRENDS_AUTOPHAGY_LOW
58
IntAct
19
HPRD
BIND
37
HPRD
28
IntAct
41
HPRD
BioGrid
45
Jorgensen_EphR
87
BioGrid_Mouse
BioGrid
43
IntAct
27
HPRD
12
IntAct
31
BioGrid
32
HPRD
BioGrid
106
HPRD
39
HPRD
BioGrid
80
IntAct
4
BEHRENDS_AUTOPHAGY_LOW
14
HPRD
BioGrid
87
HPRD
BioGrid
71
BioGrid
73
BioGrid
8
HPRD
83
BioGrid_Yeast
34
HPRD
BioGrid
7
IntAct
43
Jorgensen_EphR
14
HPRD
BioGrid
18
INNATEDB_Mouse
INNATEDB
HPRD
9
HPRD
BioGrid
40
HPRD
46
HPRD
BioGrid
38
HPRD
BIND
BioGrid
113
Blagoev
HPRD
BioGrid_Mouse
MINT_Mouse
IntAct
BioGrid
91
BioGrid_Mouse
MINT_Mouse
BioGrid
BIND
IntAct_Fly
INNATEDB
MGI
HPRD
BIND_Fly
IntAct
MINT
MINT_Fly
FlyHigh
23
BioGrid
30
HPRD
BIND
60
HPRD
BioGrid
IntAct
BIND
MINT
47
HPRD
131
Jorgensen_EphR
15
HPRD
BioGrid
MINT
39
BioGrid
18
HPRD
IntAct
14
BioGrid
45
IntAct_Worm
MINT_Worm
BIND_Worm
BioGrid_Worm
CE_DATA
44
BioGrid
15
HPRD
BioGrid
MINT
7
BioGrid
206
IntAct_Mouse
128
Krogan_NonCore
17
BioGrid
68
HPRD
BIND
104
SOURAV_MAPK_HIGH
13
MGI
INNATEDB
BIND_Mouse
INNATEDB_Mouse
HPRD
BioGrid
4
HPRD
BioGrid
21
YeastLow
7
HPRD
BioGrid
MINT
23
BIND
24
IntAct
MINT
27
HPRD
IntAct
50
Jorgensen_EphR
57
BioGrid
52
HPRD
62
IntAct
108
HPRD
12
HPRD
BioGrid
125
HPRD
BIND
BioGrid
MINT
42
HPRD
BioGrid
70
HPRD
BioGrid
MINT
63
HPRD
59
HPRD
20
BIND
6
BEHRENDS_AUTOPHAGY_LOW
74
HPRD
BioGrid
25
BioGrid
118
SOURAV_MAPK_LOW
159
HPRD
77
HPRD
MINT
114
INNATEDB
4
JonesErbB1
HPRD
IntAct
MINT
31
IntAct_Worm
HPRD
MINT_Worm
IntAct_Mouse
BIND_Worm
IntAct
BIND
BioGrid
MINT
IntAct_Rat
2
HPRD
19
Pawson4
JonesErbB1
HPRD
IntAct
BIND
BioGrid
MINT
10
INNATEDB_Mouse
INNATEDB
HPRD
BioGrid
IntAct
MINT
9
HPRD
BIND
BioGrid
94
INNATEDB
HPRD
IntAct_Mouse
BioGrid
14
HPRD
35
BioGrid
142
HPRD
BIND
59
Blagoev
HPRD
IntAct
BioGrid
7
BEHRENDS_AUTOPHAGY_LOW
23
HPRD
BioGrid
27
INNATEDB
23
HPRD
BioGrid
107
FlyLow
IntAct_Fly
MINT_Fly
35
IntAct
4
HPRD
IntAct_Mouse
BIND
BioGrid
33
IntAct
19
HPRD
IntAct
BioGrid
37
MYTH_EGFR
IntAct
26
HPRD
BIND
BioGrid
38
INNATEDB
HPRD
BioGrid
28
BioGrid
50
INNATEDB
HPRD
BioGrid
MINT
7
HPRD
BioGrid
67
MINT
27
IntAct
BioGrid
135
MINT_Rat
HPRD
BioGrid
IntAct
BIND
MINT
33
MINT
70
IntAct
115
HPRD
40
INNATEDB
HPRD
MINT_Mouse
38
BIND
IntAct
206
HPRD
72
INNATEDB
12
HPRD
BioGrid
10
IntAct
21
BioGrid
18
HPRD
BIND
BioGrid
17
HPRD
13
BioGrid
171
IntAct
2
INNATEDB_Mouse
HPRD
BioGrid
20
IntAct
BioGrid
59
HPRD
10
BioGrid
MIPS
28
INNATEDB_Mouse
HPRD
38
HPRD
IntAct
83
BioGrid_Yeast
5
BioGrid
17
BioGrid
29
BioGrid
7
HPRD
BioGrid
49
INNATEDB
HPRD
BioGrid
14
HPRD
BioGrid
67
BioGrid
41
HPRD
121
HPRD
67
HPRD
BioGrid
49
HPRD
BioGrid_Mouse
BioGrid
BIND
22
BEHRENDS_AUTOPHAGY_LOW
97
BioGrid
16
HPRD
BioGrid
80
HPRD
BioGrid
38
IntAct
228
BioGrid
21
HPRD
BioGrid
79
HPRD
BioGrid
164
HPRD
BioGrid
52
HPRD
BioGrid
35
IntAct
3
HPRD
16
IntAct
11
BEHRENDS_AUTOPHAGY_LOW
22
HPRD
BioGrid
9
ShawnLi
HPRD
BioGrid
IntAct
MINT
24
Krogan_NonCore
37
BioGrid
38
INNATEDB
HPRD
BIND
BioGrid
82
IntAct
51
HPRD
BioGrid
44
SOURAV_MAPK_LOW
15
HPRD
18
HPRD
40
HPRD
BioGrid
50
HPRD
28
BIND_Mouse
17
BIND_Yeast
BioGrid_Yeast
13
IntAct
66
INNATEDB
BIND
BioGrid
IntAct
11
IntAct
MINT
159
IntAct
107
BioGrid
108
IntAct
59
HPRD
BioGrid
105
HPRD
IntAct
64
IntAct
26
BEHRENDS_AUTOPHAGY_LOW
52
MINT
11
IntAct
44
HPRD
91
ShawnLi
IntAct
MINT
56
IntAct
18
HPRD
BIND
206
IntAct_Yeast
277
HPRD
BioGrid
48
BEHRENDS_AUTOPHAGY_LOW
18
HPRD
3
Yu_GoldStd
HPRD
BIND_Yeast
BioGrid_Yeast
25
BioGrid
23
IntAct
56
HPRD
158
BioGrid
83
HPRD
28
IntAct
71
INNATEDB
59
INNATEDB
32
IntAct
127
HPRD
BIND
BioGrid
MINT
37
HPRD
BioGrid
158
BioGrid
34
HPRD
BioGrid
7
HPRD
BioGrid
44
INNATEDB_Mouse
INNATEDB
29
MYTH_EGFR
BIND
30
INNATEDB
HPRD
BioGrid
16
HPRD
BioGrid
40
HPRD
96
HPRD
MINT_Mouse
IntAct
BioGrid
MINT
159
BioGrid
15
HPRD
31
HPRD
BIND
IntAct
79
HPRD
BioGrid
59
Jorgensen_EphR
90
HPRD
BioGrid
48
HPRD
26
INNATEDB
HPRD
BioGrid
48
INNATEDB
78
HPRD
BioGrid
62
MINT
129
INNATEDB
86
HPRD
BIND
BioGrid
MINT
23
IntAct_Worm
MINT_Worm
BIND_Worm
BioGrid_Worm
CE_DATA
54
HPRD
26
BioGrid
20
INTEROLOG
BioGrid_Yeast
MIPS
162
IntAct
12
HPRD
BIND
42
IntAct
27
HPRD
IntAct
BioGrid
MINT
240
INNATEDB
51
INNATEDB
37
HPRD
BioGrid
14
HPRD
BioGrid
BIND
MINT
39
HPRD
22
BEHRENDS_AUTOPHAGY_LOW
28
BioGrid
7
Jorgensen_EphR
34
IntAct
14
HPRD
50
BEHRENDS_AUTOPHAGY_LOW
31
BioGrid
IntAct
BIND
13
BioGrid
89
HPRD
BioGrid
6
HPRD
31
HPRD
BIND
75
HPRD
BioGrid
74
HPRD
BioGrid
5
HPRD
IntAct_Mouse
VidalHuman_core
IntAct
BIND
BioGrid
MINT
IntAct_Rat
11
HPRD
42
INNATEDB
HPRD
IntAct
BIND
BioGrid
MINT
48
BIND
28
BioGrid
IntAct
29
IntAct
46
HPRD
BioGrid
MINT
13
BioGrid
22
BIND_Mouse
INNATEDB
HPRD
BIND
BioGrid
MINT
11
HPRD
BEHRENDS_AUTOPHAGY_LOW
BIND
BioGrid
199
HPRD
BIND
16
BioGrid
BIND
35
HPRD
IntAct
3
HPRD
IntAct_Mouse
BioGrid
IntAct
BIND
IntAct_Rat
17
HPRD
MINT
9
MINT
16
Blagoev
HPRD
IntAct
BioGrid
MINT
55
INNATEDB
HPRD
BIND
BioGrid
38
BIND
112
MYTH_EGFR
BioGrid
18
INNATEDB
52
HPRD
4
BEHRENDS_AUTOPHAGY_LOW
7
HPRD
31
MGI
HPRD
49
HPRD
BioGrid
35
MINT_Mouse
16
JonesErbB1
98
MINT_Mouse
BioGrid
15
HPRD
BioGrid
35
IntAct
BioGrid
BIND
70
HPRD
58
HPRD
115
HPRD
BIND
IntAct
206
HPRD
BioGrid
MINT
145
HPRD
13
HPRD
IntAct
13
BioGrid
66
HPRD
8
BEHRENDS_AUTOPHAGY_LOW
65
HPRD
181
BioGrid
15
INNATEDB
BioGrid
MINT
14
HPRD
11
HPRD
4
BEHRENDS_AUTOPHAGY_LOW
107
HPRD
IntAct
BIND
MINT
6
HPRD
BioGrid
90
HPRD
BioGrid
22
BioGrid
45
IntAct
99
IntAct
77
BioGrid_Yeast
20
HPRD
MINT_Mouse
BioGrid
109
IntAct
13
HPRD
37
HPRD
84
HPRD
141
BioGrid
25
HPRD
BIND
8
HPRD
13
HPRD
IntAct
40
INNATEDB
BIND
180
BioGrid
47
BioGrid_Yeast
107
INNATEDB
MGI
HPRD
MINT
85
BIND_Fly
BioGrid_Fly
FlyEmbryo
IntAct_Fly
2
HPRD
BioGrid
8
BEHRENDS_AUTOPHAGY_LOW
60
INNATEDB_Mouse
INNATEDB
7
HPRD
74
BioGrid
34
BEHRENDS_AUTOPHAGY_LOW
108
HPRD
BIND
61
HPRD
18
IntAct
92
HPRD
30
HPRD
BIND
MINT
22
HPRD
BIND
BioGrid
80
BioGrid
96
HPRD
9
IntAct
MINT
98
INNATEDB
151
BioGrid
12
HPRD
10
IntAct
SOURAV_MAPK_HIGH
47
HPRD
IntAct
45
YeastLow
164
IntAct
74
MINT
43
IntAct
5
IntAct_Mouse
59
HPRD
IntAct
BioGrid
34
HPRD
BIND
BioGrid
99
MINT
52
HPRD
BioGrid
MINT
171
BioGrid_Fly
69
HPRD
IntAct_Mouse
46
HPRD
31
INNATEDB
17
HPRD
BIND
19
HPRD
59
HPRD
BIND
BioGrid
IntAct
167
MGI
18
BioGrid
90
SOURAV_MAPK_HIGH
32
HPRD
BioGrid
17
HPRD
BioGrid
77
HPRD
BIND
72
MGI
BIND_Mouse
HPRD
BIND_Rat
IntAct
BIND
BioGrid
MINT
59
HPRD
82
HPRD
BioGrid
5
HPRD
50
HPRD
26
HPRD
32
INNATEDB_Mouse
HPRD
21
INNATEDB
31
IntAct
63
HPRD
BioGrid
7
YeastLow
72
SOURAV_MAPK_LOW
10
HPRD
7
HPRD
IntAct
62
HPRD
BioGrid
155
Moran_EGFR
18
HPRD
60
HPRD
BioGrid
49
BEHRENDS_AUTOPHAGY_LOW
85
INNATEDB
38
HPRD
14
HPRD
BioGrid
8
MINT_Yeast
BioGrid_Yeast
YeastLow
IntAct_Yeast
5
INNATEDB_Mouse
133
INNATEDB_Mouse
INNATEDB
206
HPRD
IntAct
BioGrid
34
INNATEDB_Mouse
34
INNATEDB
65
HPRD
BioGrid
30
INNATEDB
9
HPRD
6
Yu_GoldStd
BIND_Yeast
MINT_Yeast
BioGrid
BIND
BioGrid_Worm
MIPS
IntAct_Worm
HPRD
MINT_Worm
Krogan_NonCore
BioGrid_Yeast
IntAct
BioGrid_Fly
YeastLow
MINT
IntAct_Yeast
30
BioGrid
13
HPRD
81
JonesErbB1
MINT
32
HPRD
BIND
BioGrid
39
HPRD
17
HPRD
BioGrid
BIND
450
HPRD
IntAct
BioGrid
46
INNATEDB
46
HPRD
IntAct
BIND
BioGrid
MINT
8
BIND_Fly
BioGrid_Fly
18
HPRD
BIND
11
BioGrid_Mouse
62
HPRD
BioGrid
78
HPRD
12
INNATEDB
10
MINT_Rat
HPRD
BIND_Rat
BIND
5
MINT_Yeast
BioGrid_Yeast
BioGrid
YeastLow
IntAct_Yeast
115
MINT
64
HPRD
BIND
BioGrid
IntAct
42
HPRD
40
HPRD
IntAct_Rat
8
HPRD
167
HPRD
BioGrid
BIND
281
HPRD
BioGrid
4
BioGrid
44
BioGrid
MINT
22
BEHRENDS_AUTOPHAGY_LOW
88
YeastMedium
20
HPRD
BioGrid
16
BIND
63
INNATEDB
37
IntAct
MINT
37
INNATEDB
9
HPRD
BioGrid
112
HPRD
IntAct
BioGrid
64
BioGrid
122
HPRD
17
HPRD
BioGrid
MINT
125
BioGrid
1
HPRD
BioGrid
27
HPRD
MINT
100
HPRD
34
FlyEmbryo
17
HPRD
BIND
BioGrid
32
INNATEDB
7
BEHRENDS_AUTOPHAGY_LOW
216
HPRD
BioGrid
34
BioGrid
MINT
206
HPRD
47
HPRD
32
HPRD
BioGrid
MINT
93
Jorgensen_EphR
28
BEHRENDS_AUTOPHAGY_LOW
9
HPRD
MINT_Mouse
IntAct
BIND
BioGrid
MINT
6
HPRD
BioGrid
12
BEHRENDS_AUTOPHAGY_LOW
IntAct
BioGrid
4
INNATEDB
98
BioGrid
37
HPRD
30
IntAct
BioGrid
126
IntAct
11
HPRD
16
HPRD
71
HPRD
BioGrid
69
HPRD
BioGrid
MINT
228
HPRD
61
INNATEDB
HPRD
BioGrid
42
MINT_Mouse
6
HPRD
BIND
2
INNATEDB_Mouse
INNATEDB
HPRD
BioGrid
17
ShawnLi
IntAct
MINT
166
IntAct_Mouse
10
IntAct
BioGrid
7
INNATEDB_Mouse
HPRD
BioGrid
410
HPRD
12
HPRD
19
HPRD
BioGrid
13
BEHRENDS_AUTOPHAGY_LOW
139
BioGrid
35
BioGrid
24
HPRD
16
INNATEDB
HPRD
BioGrid