Table S4. DNase-I hotspots in IMR90 (hg19) Chromsome Start End Id Density chr1 521497 521647 id-25569 8 chr1 565557 565707 id-27772 21.000000 chr1 565877 566027 id-27788 43.000000 chr1 566737 566887 id-27831 25.000000 chr1 567017 567167 id-27845 22.000000 chr1 567577 567727 id-27873 473.000000 chr1 567757 567907 id-27882 53.000000 chr1 568137 568287 id-27901 34.000000 chr1 568357 568507 id-27912 76.000000 chr1 569817 569967 id-27985 16303.000000 chr1 714057 714207 id-35197 168.000000 chr1 752637 752787 id-37126 83.000000 chr1 753417 753567 id-37165 24.000000 chr1 762817 762967 id-37635 18.000000 chr1 785857 786007 id-38787 9 chr1 786857 787007 id-38837 11.000000 chr1 826237 826387 id-40806 14.000000 chr1 840077 840227 id-41498 14 chr1 842197 842347 id-41604 13 chr1 856517 856667 id-42320 19.000000 chr1 859097 859247 id-42449 16.000000 chr1 875777 875927 id-43283 16.000000 chr1 877037 877187 id-43346 9 chr1 879817 879967 id-43485 29.000000 chr1 894597 894747 id-44224 24.000000 chr1 895817 895967 id-44285 11 chr1 902297 902447 id-44609 14.000000 chr1 935477 935627 id-46268 37.000000 chr1 936197 936347 id-46304 30.000000 chr1 940737 940887 id-46531 16.000000 chr1 948717 948867 id-46930 28.000000 chr1 954837 954987 id-47236 25.000000 chr1 956537 956687 id-47321 20.000000 chr1 968497 968647 id-47919 14.000000 chr1 976177 976327 id-48303 34.000000 chr1 994957 995107 id-49242 13.000000 chr1 999617 999767 id-49475 63.000000 chr1 1014937 1015087 id-50241 26.000000 chr1 1051597 1051747 id-52074 92.000000 chr1 1057597 1057747 id-52374 10 chr1 1068817 1068967 id-52935 9 chr1 1092897 1093047 id-54139 30.000000 chr1 1123457 1123607 id-55667 29.000000 chr1 1136797 1136947 id-56334 11 chr1 1143477 1143627 id-56668 46.000000 chr1 1158197 1158347 id-57404 13.000000 chr1 1166157 1166307 id-57802 31.000000 chr1 1167397 1167547 id-57864 85.000000 chr1 1199637 1199787 id-59476 9 chr1 1200317 1200467 id-59510 239.000000 chr1 1200837 1200987 id-59536 65.000000 chr1 1206337 1206487 id-59811 21.000000 chr1 1209197 1209347 id-59954 41.000000 chr1 1211297 1211447 id-60059 13.000000 chr1 1217577 1217727 id-60373 18.000000 chr1 1218377 1218527 id-60413 15.000000 chr1 1227277 1227427 id-60858 11 chr1 1240157 1240307 id-61502 40.000000 chr1 1241057 1241207 id-61547 22.000000 chr1 1243337 1243487 id-61661 32.000000 chr1 1243697 1243847 id-61679 56.000000 chr1 1253737 1253887 id-62181 106.000000 chr1 1259997 1260147 id-62494 25.000000 chr1 1280257 1280407 id-63507 12 chr1 1283397 1283547 id-63664 12 chr1 1285077 1285227 id-63748 10 chr1 1287577 1287727 id-63873 13.000000 chr1 1293957 1294107 id-64192 34.000000 chr1 1294737 1294887 id-64231 38.000000 chr1 1295237 1295387 id-64256 21.000000 chr1 1296057 1296207 id-64297 76.000000 chr1 1297477 1297627 id-64368 39.000000 chr1 1307657 1307807 id-64877 8 chr1 1310697 1310847 id-65029 224.000000 chr1 1334777 1334927 id-66233 154.000000 chr1 1337477 1337627 id-66368 18.000000 chr1 1342617 1342767 id-66625 34.000000 chr1 1358257 1358407 id-67407 12.000000 chr1 1365717 1365867 id-67780 16.000000 chr1 1369277 1369427 id-67958 8 chr1 1371017 1371167 id-68045 16.000000 chr1 1407017 1407167 id-69845 40.000000 chr1 1440377 1440527 id-71513 12 chr1 1447037 1447187 id-71846 27.000000 chr1 1447337 1447487 id-71861 105.000000 chr1 1475917 1476067 id-73290 20.000000 chr1 1477397 1477547 id-73364 7 chr1 1490317 1490467 id-74010 28.000000 chr1 1509257 1509407 id-74957 11 chr1 1510217 1510367 id-75005 50.000000 chr1 1535017 1535167 id-76245 9 chr1 1549657 1549807 id-76977 43.000000 chr1 1550697 1550847 id-77029 101.000000 chr1 1551097 1551247 id-77049 17.000000 chr1 1557737 1557887 id-77381 21.000000 chr1 1590577 1590727 id-79023 81.000000 chr1 1593957 1594107 id-79192 7 chr1 1617777 1617927 id-80383 88.000000 chr1 1623840 1623990 id-80686 16.000000 chr1 1624180 1624330 id-80703 44.000000 chr1 1624540 1624690 id-80721 14.000000 chr1 1655720 1655870 id-82280 50.000000 chr1 1672540 1672690 id-83121 80.000000 chr1 1677560 1677710 id-83372 19.000000 chr1 1709840 1709990 id-84986 11 chr1 1790200 1790350 id-89004 21.000000 chr1 1800280 1800430 id-89508 12 chr1 1822540 1822690 id-90621 49.000000 chr1 1837700 1837850 id-91379 30.000000 chr1 1840700 1840850 id-91529 43.000000 chr1 1850820 1850970 id-92035 54.000000 chr1 2005000 2005150 id-99744 12 chr1 2020000 2020150 id-100494 32.000000 chr1 2040140 2040290 id-101501 10 chr1 2063720 2063870 id-102680 39.000000 chr1 2064100 2064250 id-102699 42.000000 chr1 2064540 2064690 id-102721 159.000000 chr1 2064740 2064890 id-102731 178.000000 chr1 2067040 2067190 id-102846 69.000000 chr1 2071580 2071730 id-103073 44.000000 chr1 2101800 2101950 id-104584 14.000000 chr1 2105840 2105990 id-104786 11 chr1 2112040 2112190 id-105096 7 chr1 2121080 2121230 id-105548 104.000000 chr1 2121560 2121710 id-105572 14.000000 chr1 2123720 2123870 id-105680 15.000000 chr1 2126460 2126610 id-105817 19.000000 chr1 2126740 2126890 id-105831 27.000000 chr1 2130800 2130950 id-106034 56.000000 chr1 2136240 2136390 id-106306 22.000000 chr1 2136660 2136810 id-106327 62.000000 chr1 2139300 2139450 id-106459 11 chr1 2139740 2139890 id-106481 47.000000 chr1 2143980 2144130 id-106693 118.000000 chr1 2144340 2144490 id-106711 13.000000 chr1 2144580 2144730 id-106723 17.000000 chr1 2145620 2145770 id-106775 56.000000 chr1 2159240 2159390 id-107456 87.000000 chr1 2160600 2160750 id-107524 21.000000 chr1 2161980 2162130 id-107593 10 chr1 2163500 2163650 id-107669 30.000000 chr1 2166080 2166230 id-107798 33.000000 chr1 2177620 2177770 id-108375 19.000000 chr1 2177920 2178070 id-108390 24.000000 chr1 2187360 2187510 id-108862 16.000000 chr1 2187620 2187770 id-108875 16.000000 chr1 2201980 2202130 id-109593 9 chr1 2207400 2207550 id-109864 22.000000 chr1 2208760 2208910 id-109932 11 chr1 2210820 2210970 id-110035 100.000000 chr1 2222260 2222410 id-110607 127.000000 chr1 2225600 2225750 id-110774 10 chr1 2227820 2227970 id-110885 20.000000 chr1 2232480 2232630 id-111118 18.000000 chr1 2243020 2243170 id-111645 21.000000 chr1 2246380 2246530 id-111813 13.000000 chr1 2248160 2248310 id-111902 10 chr1 2253720 2253870 id-112180 37.000000 chr1 2262320 2262470 id-112610 34.000000 chr1 2313300 2313450 id-115159 17.000000 chr1 2323040 2323190 id-115646 129.000000 chr1 2336600 2336750 id-116324 8 chr1 2337540 2337690 id-116371 9 chr1 2344020 2344170 id-116695 53.000000 chr1 2383280 2383430 id-118658 61.000000 chr1 2391380 2391530 id-119063 23.000000 chr1 2440080 2440230 id-121498 10 chr1 2454720 2454870 id-122230 11 chr1 2457660 2457810 id-122377 50.000000 chr1 2457980 2458130 id-122393 33.000000 chr1 2466440 2466590 id-122816 17.000000 chr1 2477520 2477670 id-123370 25.000000 chr1 2478420 2478570 id-123415 18.000000 chr1 2479520 2479670 id-123470 11 chr1 2480180 2480330 id-123503 8 chr1 2487927 2488077 id-124318 8 chr1 2516960 2517110 id-125342 11 chr1 2517900 2518050 id-125389 146.000000 chr1 2574640 2574790 id-128226 42.000000 chr1 2584900 2585050 id-128739 8 chr1 2585600 2585750 id-128774 10 chr1 3223180 3223330 id-160653 21.000000 chr1 3229760 3229910 id-160982 135.000000 chr1 3230340 3230490 id-161011 26.000000 chr1 3231540 3231690 id-161071 17.000000 chr1 3236640 3236790 id-161326 10 chr1 3237220 3237370 id-161355 7 chr1 3286460 3286610 id-163817 20.000000 chr1 3369800 3369950 id-167984 10 chr1 3390240 3390390 id-169006 33.000000 chr1 3418780 3418930 id-170433 11 chr1 3420900 3421050 id-170539 30.000000 chr1 3459640 3459790 id-172476 16.000000 chr1 3459980 3460130 id-172493 56.000000 chr1 3462440 3462590 id-172616 13.000000 chr1 3464900 3465050 id-172739 15.000000 chr1 3504020 3504170 id-174695 8 chr1 3530100 3530250 id-175999 29.000000 chr1 3535620 3535770 id-176275 25.000000 chr1 3541320 3541470 id-176560 52.000000 chr1 3566620 3566770 id-177825 42.000000 chr1 3595960 3596110 id-179292 12 chr1 3663900 3664050 id-182689 17.000000 chr1 3689120 3689270 id-183950 26.000000 chr1 3692100 3692250 id-184099 13.000000 chr1 3713020 3713170 id-185145 32.000000 chr1 3773760 3773910 id-188182 21.000000 chr1 3774860 3775010 id-188237 13.000000 chr1 3817240 3817390 id-190356 129.000000 chr1 3817880 3818030 id-190388 102.000000 chr1 5727513 5727663 id-282506 12 chr1 5728433 5728583 id-282552 8 chr1 5730373 5730523 id-282649 12.000000 chr1 5732353 5732503 id-282748 14.000000 chr1 5976173 5976323 id-294939 13.000000 chr1 5998533 5998683 id-296057 23.000000 chr1 6035313 6035463 id-297896 14 chr1 6043513 6043663 id-298306 74.000000 chr1 6051413 6051563 id-298701 7 chr1 6052573 6052723 id-298759 226.000000 chr1 6076393 6076543 id-299950 15.000000 chr1 6113073 6113223 id-301784 22.000000 chr1 6243753 6243903 id-308318 7 chr1 6245353 6245503 id-308398 36.000000 chr1 6259713 6259863 id-309116 193.000000 chr1 6265253 6265403 id-309393 9 chr1 6268833 6268983 id-309572 12 chr1 6280473 6280623 id-310154 14.000000 chr1 6282733 6282883 id-310267 8 chr1 6294713 6294863 id-310866 14.000000 chr1 6296013 6296163 id-310931 44.000000 chr1 6305193 6305343 id-311390 28.000000 chr1 6320133 6320283 id-312137 15.000000 chr1 6327933 6328083 id-312527 8 chr1 6333493 6333643 id-312805 21.000000 chr1 6336593 6336743 id-312960 55.000000 chr1 6390013 6390163 id-315631 14.000000 chr1 6390573 6390723 id-315659 30.000000 chr1 6403633 6403783 id-316312 20.000000 chr1 6419053 6419203 id-317083 83.000000 chr1 6419793 6419943 id-317120 74.000000 chr1 6423233 6423383 id-317292 11.000000 chr1 6427953 6428103 id-317528 10 chr1 6445893 6446043 id-318425 13 chr1 6453473 6453623 id-318804 16.000000 chr1 6453813 6453963 id-318821 18.000000 chr1 6454053 6454203 id-318833 15.000000 chr1 6464793 6464943 id-319370 18.000000 chr1 6546633 6546783 id-323462 29.000000 chr1 6550033 6550183 id-323632 16.000000 chr1 6550593 6550743 id-323660 15.000000 chr1 6551713 6551863 id-323716 21.000000 chr1 6577613 6577763 id-325011 12 chr1 6580153 6580303 id-325138 28.000000 chr1 6583793 6583943 id-325320 11 chr1 6599093 6599243 id-326085 31.000000 chr1 6605013 6605163 id-326381 24.000000 chr1 6614513 6614663 id-326856 38.000000 chr1 6639913 6640063 id-328126 75.000000 chr1 6661273 6661423 id-329194 87.000000 chr1 6662553 6662703 id-329258 21.000000 chr1 6662933 6663083 id-329277 42.000000 chr1 6663533 6663683 id-329307 27.000000 chr1 6664373 6664523 id-329349 44.000000 chr1 6673573 6673723 id-329809 149.000000 chr1 6684873 6685023 id-330374 50.000000 chr1 6685933 6686083 id-330427 19.000000 chr1 6694713 6694863 id-330866 10 chr1 6696573 6696723 id-330959 9 chr1 6698413 6698563 id-331051 19.000000 chr1 6706653 6706803 id-331463 13 chr1 6734173 6734323 id-332839 9 chr1 6746313 6746463 id-333446 30.000000 chr1 6748173 6748323 id-333539 14.000000 chr1 6761833 6761983 id-334222 35.000000 chr1 6763153 6763303 id-334288 11 chr1 6780173 6780323 id-335139 32.000000 chr1 6784633 6784783 id-335362 69.000000 chr1 6785033 6785183 id-335382 27.000000 chr1 6787633 6787783 id-335512 16.000000 chr1 6794733 6794883 id-335867 8 chr1 6803993 6804143 id-336330 29.000000 chr1 6830933 6831083 id-337677 8 chr1 6844573 6844723 id-338359 76.000000 chr1 6845133 6845283 id-338387 296.000000 chr1 6854373 6854523 id-338849 28.000000 chr1 6855793 6855943 id-338920 92.000000 chr1 6859413 6859563 id-339101 7 chr1 6859893 6860043 id-339125 15.000000 chr1 6860913 6861063 id-339176 38.000000 chr1 6862193 6862343 id-339240 23.000000 chr1 6863513 6863663 id-339306 20.000000 chr1 6879793 6879943 id-340120 13 chr1 6920173 6920323 id-342139 135.000000 chr1 6930713 6930863 id-342666 16.000000 chr1 6932713 6932863 id-342766 12 chr1 6933733 6933883 id-342817 14.000000 chr1 6948453 6948603 id-343553 16.000000 chr1 6950073 6950223 id-343634 12 chr1 7020673 7020823 id-347164 7 chr1 7051453 7051603 id-348703 22.000000 chr1 7102873 7103023 id-351274 14.000000 chr1 7106513 7106663 id-351456 19.000000 chr1 7130553 7130703 id-352658 20.000000 chr1 7135473 7135623 id-352904 15.000000 chr1 7161393 7161543 id-354200 12.000000 chr1 7163733 7163883 id-354317 6 chr1 7177693 7177843 id-355015 71.000000 chr1 7178053 7178203 id-355033 63.000000 chr1 7249993 7250143 id-358630 13.000000 chr1 7268033 7268183 id-359532 23.000000 chr1 7278373 7278523 id-360049 21.000000 chr1 7280153 7280303 id-360138 13.000000 chr1 7283733 7283883 id-360317 106.000000 chr1 7289913 7290063 id-360626 23.000000 chr1 7313313 7313463 id-361796 23.000000 chr1 7315793 7315943 id-361920 46.000000 chr1 7323753 7323903 id-362318 13.000000 chr1 7324973 7325123 id-362379 8 chr1 7325873 7326023 id-362424 127.000000 chr1 7327693 7327843 id-362515 91.000000 chr1 7339553 7339703 id-363108 13.000000 chr1 7342013 7342163 id-363231 80.000000 chr1 7345173 7345323 id-363389 12 chr1 7351533 7351683 id-363707 20.000000 chr1 7358993 7359143 id-364080 32.000000 chr1 7359433 7359583 id-364102 261.000000 chr1 7360193 7360343 id-364140 108.000000 chr1 7361033 7361183 id-364182 136.000000 chr1 7373113 7373263 id-364786 13.000000 chr1 7375433 7375583 id-364902 10 chr1 7382553 7382703 id-365258 24.000000 chr1 7393733 7393883 id-365817 11 chr1 7394933 7395083 id-365877 19.000000 chr1 7399213 7399363 id-366091 11 chr1 7401713 7401863 id-366216 15.000000 chr1 7439593 7439743 id-368110 46.000000 chr1 7449053 7449203 id-368583 9 chr1 7449653 7449803 id-368613 8 chr1 7461993 7462143 id-369230 349.000000 chr1 7463433 7463583 id-369302 10 chr1 7484613 7484763 id-370361 7 chr1 7487253 7487403 id-370493 9 chr1 7497513 7497663 id-371006 14.000000 chr1 7531093 7531243 id-372685 236.000000 chr1 7531373 7531523 id-372699 45.000000 chr1 7531953 7532103 id-372728 47.000000 chr1 7539053 7539203 id-373083 256.000000 chr1 7551653 7551803 id-373713 58.000000 chr1 7569333 7569483 id-374597 10 chr1 7587273 7587423 id-375494 33.000000 chr1 7598193 7598343 id-376040 18.000000 chr1 7601853 7602003 id-376223 43.000000 chr1 7609493 7609643 id-376605 27.000000 chr1 7612673 7612823 id-376764 10 chr1 7637373 7637523 id-377999 9 chr1 7703653 7703803 id-381313 8 chr1 7705033 7705183 id-381382 11 chr1 7727753 7727903 id-382518 25.000000 chr1 7728633 7728783 id-382562 69.000000 chr1 7764593 7764743 id-384360 19.000000 chr1 7812993 7813143 id-386780 30.000000 chr1 7831253 7831403 id-387693 18.000000 chr1 7843513 7843663 id-388306 14.000000 chr1 7843993 7844143 id-388330 103.000000 chr1 7868393 7868543 id-389550 11.000000 chr1 7870573 7870723 id-389659 70.000000 chr1 7905973 7906123 id-391429 83.000000 chr1 7907813 7907963 id-391521 72.000000 chr1 7948793 7948943 id-393570 12 chr1 7954013 7954163 id-393831 36.000000 chr1 7957173 7957323 id-393989 21.000000 chr1 7959813 7959963 id-394121 10 chr1 7962893 7963043 id-394275 16.000000 chr1 7980753 7980903 id-395168 34.000000 chr1 8002413 8002563 id-396251 11 chr1 8009133 8009283 id-396587 53.000000 chr1 8014233 8014383 id-396842 8 chr1 8016813 8016963 id-396971 46.000000 chr1 8021593 8021743 id-397210 196.000000 chr1 8035433 8035583 id-397902 26.000000 chr1 8037333 8037483 id-397997 8 chr1 8042453 8042603 id-398253 66.000000 chr1 8048733 8048883 id-398567 21.000000 chr1 8052213 8052363 id-398741 12 chr1 8053093 8053243 id-398785 34.000000 chr1 8054293 8054443 id-398845 95.000000 chr1 8064993 8065143 id-399380 47.000000 chr1 8065333 8065483 id-399397 109.000000 chr1 8066433 8066583 id-399452 9 chr1 8075193 8075343 id-399890 44.000000 chr1 8080253 8080403 id-400143 11 chr1 8086413 8086563 id-400451 80.000000 chr1 8087573 8087723 id-400509 35.000000 chr1 8088113 8088263 id-400536 57.000000 chr1 8088473 8088623 id-400554 35.000000 chr1 8091373 8091523 id-400699 19.000000 chr1 8092493 8092643 id-400755 29.000000 chr1 8100793 8100943 id-401170 195.000000 chr1 8106133 8106283 id-401437 17.000000 chr1 8107953 8108103 id-401528 26.000000 chr1 8108313 8108463 id-401546 15.000000 chr1 8116193 8116343 id-401940 69.000000 chr1 8119253 8119403 id-402093 23.000000 chr1 8121433 8121583 id-402202 118.000000 chr1 8122193 8122343 id-402240 29.000000 chr1 8135653 8135803 id-402913 7 chr1 8137373 8137523 id-402999 62.000000 chr1 8138373 8138523 id-403049 23.000000 chr1 8143233 8143383 id-403292 33.000000 chr1 8144013 8144163 id-403331 52.000000 chr1 8150353 8150503 id-403648 144.000000 chr1 8151933 8152083 id-403727 7 chr1 8154653 8154803 id-403863 34.000000 chr1 8155113 8155263 id-403886 42.000000 chr1 8156693 8156843 id-403965 49.000000 chr1 8157613 8157763 id-404011 109.000000 chr1 8167273 8167423 id-404494 10 chr1 8168073 8168223 id-404534 10 chr1 8177113 8177263 id-404986 73.000000 chr1 8180813 8180963 id-405171 10 chr1 8181493 8181643 id-405205 90.000000 chr1 8182273 8182423 id-405244 23.000000 chr1 8182853 8183003 id-405273 45.000000 chr1 8187573 8187723 id-405509 18.000000 chr1 8193833 8193983 id-405822 88.000000 chr1 8194213 8194363 id-405841 31.000000 chr1 8197833 8197983 id-406022 125.000000 chr1 8203153 8203303 id-406288 16.000000 chr1 8214793 8214943 id-406870 17.000000 chr1 8229433 8229583 id-407602 19.000000 chr1 8229893 8230043 id-407625 47.000000 chr1 8231913 8232063 id-407726 21.000000 chr1 8242273 8242423 id-408244 14.000000 chr1 8250033 8250183 id-408632 11 chr1 8254733 8254883 id-408867 21.000000 chr1 8257873 8258023 id-409024 86.000000 chr1 8262313 8262463 id-409246 104.000000 chr1 8262693 8262843 id-409265 63.000000 chr1 8264693 8264843 id-409365 8 chr1 8272093 8272243 id-409735 174.000000 chr1 8275053 8275203 id-409883 11 chr1 8276273 8276423 id-409944 30.000000 chr1 8278793 8278943 id-410070 12.000000 chr1 8279793 8279943 id-410120 10 chr1 8280413 8280563 id-410151 14.000000 chr1 8285033 8285183 id-410382 44.000000 chr1 8289733 8289883 id-410617 14.000000 chr1 8290173 8290323 id-410639 72.000000 chr1 8295153 8295303 id-410888 8 chr1 8298273 8298423 id-411044 135.000000 chr1 8299113 8299263 id-411086 13 chr1 8319553 8319703 id-412108 25.000000 chr1 8323233 8323383 id-412292 15.000000 chr1 8344333 8344483 id-413347 23.000000 chr1 8363353 8363503 id-414298 64.000000 chr1 8374433 8374583 id-414852 27.000000 chr1 8378093 8378243 id-415035 10 chr1 8402533 8402683 id-416257 11 chr1 8403573 8403723 id-416309 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