TY - JOUR T1 - Reduction in Learning Rates Associated with Anterograde Interference Results from Interactions between Different Timescales in Motor Adaptation A1 - Sing, Gary C. A1 - Smith, Maurice A. Y1 - 2010/08/19 N2 - Author Summary The act of learning one task can not only have direct effects on the performance of other tasks, but it can also affect the ability to learn other tasks. One example of the latter is the phenomenon of anterograde interference in motor adaptation, in which the learning of one adaptation can substantially reduce the rate at which the opposite adaptation can be learned. Here we show that the amount of anterograde interference depends systematically on the strength of a particular component of the initial adaptation rather than on the total amount of adaptation that is achieved. This component of the motor memory evolves more slowly than the overall learning and acts in combination with a quickly evolving component of memory to produce the observed improvement in task performance. We proceed to show that a simple computational model of the interactions between these adaptive processes predicts greater than 90% of the variance in the observed interference patterns, suggesting that this quantitative model may enable the development of improved training and rehabilitation paradigms that mitigate unwanted interference. JF - PLOS Computational Biology JA - PLOS Computational Biology VL - 6 IS - 8 UR - https://doi.org/10.1371/journal.pcbi.1000893 SP - e1000893 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pcbi.1000893 ER -