TY - JOUR T1 - Dynamic Changes in Protein Functional Linkage Networks Revealed by Integration with Gene Expression Data A1 - Hegde, Shubhada R. A1 - Manimaran, Palanisamy A1 - Mande, Shekhar C. Y1 - 2008/11/28 N2 - Author Summary Many cellular processes and the response of cells to environmental cues are determined by the intricate proteināˆ¶protein interactions. These cellular protein interactions can be represented in the form of a graph, where the nodes represent the proteins and the edges signify the interactions between them. However, the available protein functional linkage maps do not incorporate the dynamics of gene expression and thus do not portray the dynamics of true proteināˆ¶protein interactions in vivo. We have used gene expression data as well as the available protein functional interaction information for Escherichia coli to build the protein interaction networks for expressed genes in a given condition. These networks, named conditional networks, capture the differences in the protein interaction networks and hence the cell physiology. Thus, by exploring the dynamics of protein interaction profiles, we hope to understand the response of cells to environmental changes. JF - PLOS Computational Biology JA - PLOS Computational Biology VL - 4 IS - 11 UR - https://doi.org/10.1371/journal.pcbi.1000237 SP - e1000237 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pcbi.1000237 ER -