TY - JOUR T1 - Quantitative Modeling of GRK-Mediated β2AR Regulation A1 - Vayttaden, Sharat J. A1 - Friedman, Jacqueline A1 - Tran, Tuan M. A1 - Rich, Thomas C. A1 - Dessauer, Carmen W. A1 - Clark, Richard B. Y1 - 2010/01/22 N2 - Author Summary The β2 adrenergic receptor (β2AR) is involved in regulating many cellular processes such as smooth muscle relaxation in the airways and the vasculature. Drugs that activate the β2AR are used in treating asthma and chronic obstructive pulmonary disorder (COPD), and prolonged use of these drugs leads to the loss of their effects. Thus, a dynamic model of how the β2AR responds to different drugs is fundamental to their rational use. In this study a consensus model of G protein coupled receptor kinase (GRK)-mediated receptor regulation was formulated based on quantitative measures of six processes involved in β2AR regulation. This model was then used to simulate the consequences of manipulating key rates associated with the GRK-mediated β2AR regulation, leading to predictions which will provide a useful framework for further tests and elaborations of the model in basic and clinical research. JF - PLOS Computational Biology JA - PLOS Computational Biology VL - 6 IS - 1 UR - https://doi.org/10.1371/journal.pcbi.1000647 SP - e1000647 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pcbi.1000647 ER -