TY - JOUR T1 - A Reaction-Diffusion Model of Human Brain Development A1 - Lefèvre, Julien A1 - Mangin, Jean-François Y1 - 2010/04/22 N2 - Author Summary The anatomical variability of the human brain folds remains an unclear and challenging issue. However it is clear that this variability is the product of the brain development. Several hypotheses coexist for explaining the rapid development of cortical sulci and it is of the highest interest that understanding their variability would improve the comparison of anatomical and functional data across cohorts of subjects. In this article we propose to extend a model of cortical folding based on interactions between growth factors that shape the cortical surface. First the originality of our approach lies in the fact that the surface on which these mechanisms take place is deformed iteratively and engenders geometric patterns that can be linked to cortical sulci. Secondly we show that some statistical properties of our model can reflect the reproducibility and the variability of sulcal structures. At the end we compare different patterns produced by the model to different pathologies of brain development. JF - PLOS Computational Biology JA - PLOS Computational Biology VL - 6 IS - 4 UR - https://doi.org/10.1371/journal.pcbi.1000749 SP - e1000749 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pcbi.1000749 ER -