TY - JOUR T1 - Promoter Complexity and Tissue-Specific Expression of Stress Response Components in Mytilus galloprovincialis, a Sessile Marine Invertebrate Species A1 - Pantzartzi, Chrysa A1 - Drosopoulou, Elena A1 - Yiangou, Minas A1 - Drozdov, Ignat A1 - Tsoka, Sophia A1 - Ouzounis, Christos A. A1 - Scouras, Zacharias G. Y1 - 2010/07/08 N2 - Author Summary Adaptation of sessile animals, such as molluscs, to stress is achieved by a number of molecular mechanisms, few of which are clearly understood. Insights from this research can provide clues about stress tolerance both for sessile and mobile organisms. The Mediterranean mussel, of the genus Mytilus, is a model organism for the study of stress at the molecular level, with sufficient gene structure and function data available. We have thus investigated a key stress response gene, Hsp90, and in particular its upstream region, using a combination of sequence and expression analysis approaches. We demonstrate that this region, responsible for the regulation of heat shock-associated gene expression, exhibits an unparalleled structural and functional complexity compared to other model organisms, as well as subtle gene expression patterns across multiple tissues. These results form the basis upon which the heat shock response can be used as a molecular biosensor for environmental monitoring in the future. JF - PLOS Computational Biology JA - PLOS Computational Biology VL - 6 IS - 7 UR - https://doi.org/10.1371/journal.pcbi.1000847 SP - e1000847 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pcbi.1000847 ER -