TY - JOUR T1 - The Human Functional Brain Network Demonstrates Structural and Dynamical Resilience to Targeted Attack A1 - Joyce, Karen E. A1 - Hayasaka, Satoru A1 - Laurienti, Paul J. Y1 - 2013/01/24 N2 - Author Summary Why can the brain endure numerous micro-strokes with seemingly no detrimental impact, until one cataclysmal stroke hinders the ability to perform essential functions such as speech and mobility? Perhaps various small regions or foci of the brain are highly important to information transfer, and the loss of such highly central foci would be severely injurious to brain function. Identification of such foci, via modeling of the functional brain using network theory, could lead to important advances with regard to brain disease and stroke. In this work, we utilized functional brain networks constructed from human volunteers to study how removing particular regions of the brain impacts brain network structure and information transfer properties. We sought to determine whether a particular measure of region importance may be able to identify highly critical regions, and whether targeting highly critical regions would have a more detrimental impact than removing regions at random. We found that, while in general targeted removal has a larger impact on network structure and dynamics, the human brain network is comparatively resilient against both targeted and random removal. JF - PLOS Computational Biology JA - PLOS Computational Biology VL - 9 IS - 1 UR - https://doi.org/10.1371/journal.pcbi.1002885 SP - e1002885 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pcbi.1002885 ER -