TY - JOUR T1 - Distinct Types of Disorder in the Human Proteome: Functional Implications for Alternative Splicing A1 - Colak, Recep A1 - Kim, TaeHyung A1 - Michaut, Magali A1 - Sun, Mark A1 - Irimia, Manuel A1 - Bellay, Jeremy A1 - Myers, Chad L. A1 - Blencowe, Benjamin J. A1 - Kim, Philip M. Y1 - 2013/04/25 N2 - Author Summary A protein's cellular and molecular function is typically determined by its folded structure. However, a large fraction of proteomes lack stably folded structure. These regions are referred to as intrinsically disordered. Protein disorder has largely been understudied, although it is emerging to have numerous important functions in a cell. Similarly, although alternative splicing (AS) is well established as an important regulatory layer of metazoan gene expression, its specific roles at the protein level are not well understood. Others and we recently have provided evidence that tissue-regulated AS likely plays a widespread role in the control of protein-protein interactions. In the present study, we investigate how two different classes of conserved protein disorder may contribute distinct functions in relation to roles of regulated alternative exons in the dynamic remodeling of interaction networks. We also investigate the distribution of cancer causing mutations in regulated and other alternatively spliced regions of proteins. JF - PLOS Computational Biology JA - PLOS Computational Biology VL - 9 IS - 4 UR - https://doi.org/10.1371/journal.pcbi.1003030 SP - e1003030 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pcbi.1003030 ER -