Targeted Molecular Dynamics Study of C-Loop Closure and Channel Gating in Nicotinic Receptors

• Xiaolin Cheng ,

  *To whom correspondence should be addressed. E-mail: xcheng@mccammon.ucsd.edu

  Affiliations Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America , NSF Center for Theoretical Biophysics, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

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• Hailong Wang,

  Affiliation Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

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• Barry Grant,

  Affiliation NSF Center for Theoretical Biophysics, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

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• Steven M Sine,

  Affiliation Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

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• J. Andrew McCammon

  Affiliations Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America , NSF Center for Theoretical Biophysics, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America , Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

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