The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics

• Haiyuan Yu ,

  Contributed equally to this work with: Haiyuan Yu, Philip M Kim

  Affiliations Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America , Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America , Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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• Philip M Kim ,

  Contributed equally to this work with: Haiyuan Yu, Philip M Kim

  Affiliation Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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• Emmett Sprecher,

  Affiliations Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America , Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

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• Valery Trifonov,

  Affiliation Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

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• Mark Gerstein

  *To whom correspondence should be addressed. E-mail: Mark.Gerstein@yale.edu

  Affiliations Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America , Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America , Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

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