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Modeling Mechanisms of In Vivo Variability in Methotrexate Accumulation and Folate Pathway Inhibition in Acute Lymphoblastic Leukemia Cells

  • John C. Panetta ,

    carl.panetta@stjude.org

    Affiliations Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

  • Alex Sparreboom,

    Affiliations Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

  • Ching-Hon Pui,

    Affiliations Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America, Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

  • Mary V. Relling,

    Affiliations Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

  • William E. Evans

    Affiliations Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

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