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Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays

  • Rameen Beroukhim ,

    Contributed equally to this work with: Rameen Beroukhim, Ming Lin

    Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

  • Ming Lin ,

    Contributed equally to this work with: Rameen Beroukhim, Ming Lin

    Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

  • Yuhyun Park,

    Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

  • Ke Hao,

    Affiliation Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

  • Xiaojun Zhao,

    Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

  • Levi A Garraway,

    Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

  • Edward A Fox,

    Affiliation Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

  • Ephraim P Hochberg,

    Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America , Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  • Ingo K Mellinghoff,

    Affiliation Departments of Medicine and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

  • Matthias D Hofer,

    Affiliations Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

  • Aurelien Descazeaud,

    Affiliations Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

  • Mark A Rubin,

    Affiliations Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

  • Matthew Meyerson,

    Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America , Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

  • Wing Hung Wong,

    Affiliation Department of Statistics, Stanford University, Stanford, California, United States of America

  • William R Sellers ,

    To whom correspondence should be addressed. E-mail: william.sellers@novartis.com (WRS); cli@hsph.harvard.edu (CL)

    ¤ Current address: Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

    Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America , Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America , Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

  •  [ ... ],
  • Cheng Li

    To whom correspondence should be addressed. E-mail: william.sellers@novartis.com (WRS); cli@hsph.harvard.edu (CL)

    Affiliations Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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