Positive and Negative Design in Stability and Thermal Adaptation of Natural Proteins

• Igor N Berezovsky,

  Affiliation Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America

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• Konstantin B Zeldovich,

  Affiliation Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America

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• Eugene I Shakhnovich

  *To whom correspondence should be addressed. E-mail: eugene@belok.harvard.edu

  Affiliation Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America

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