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Research Article

The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics

  • Haiyuan Yu equal contributor,

    equal contributor Contributed equally to this work with: Haiyuan Yu, Philip M Kim

    Affiliations: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Philip M Kim equal contributor,

    equal contributor Contributed equally to this work with: Haiyuan Yu, Philip M Kim

    Affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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  • Emmett Sprecher,

    Affiliations: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

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  • Valery Trifonov,

    Affiliation: Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

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  • Mark Gerstein mail

    To whom correspondence should be addressed. E-mail: Mark.Gerstein@yale.edu

    Affiliations: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

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  • Published: April 20, 2007
  • DOI: 10.1371/journal.pcbi.0030059

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