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Research Article

The Per2 Negative Feedback Loop Sets the Period in the Mammalian Circadian Clock Mechanism

  • A. Katharina Wilkins,

    Affiliations: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Paul I Barton,

    Affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Bruce Tidor mail

    To whom correspondence should be addressed. E-mail: tidor@mit.edu

    Affiliations: Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: December 14, 2007
  • DOI: 10.1371/journal.pcbi.0030242

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