Spatial Analysis of Expression Patterns Predicts Genetic Interactions at the Mid-Hindbrain Boundary

Dominik M. Wittmann; Florian Blöchl; Dietrich Trümbach; Wolfgang Wurst; Nilima Prakash; Fabian J. Theis

doi:10.1371/journal.pcbi.1000569

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Research Article

Spatial Analysis of Expression Patterns Predicts Genetic Interactions at the Mid-Hindbrain Boundary

Dominik M. Wittmann,

Affiliations Computational Modeling in Biology, Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Munich-Neuherberg, Germany, Zentrum Mathematik, Technische Universität München, Garching, Germany
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Florian Blöchl,

Affiliation Computational Modeling in Biology, Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Munich-Neuherberg, Germany
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Dietrich Trümbach,

Affiliations Molecular Neurogenetics, Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Technische Universität München, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich-Neuherberg, Germany, Max Planck Institute of Psychiatry, Munich, Germany
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Wolfgang Wurst,

Affiliations Molecular Neurogenetics, Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Technische Universität München, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich-Neuherberg, Germany, Max Planck Institute of Psychiatry, Munich, Germany
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Nilima Prakash,

Affiliation Molecular Neurogenetics, Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Technische Universität München, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich-Neuherberg, Germany
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Fabian J. Theis

* E-mail: fabian.theis@helmholtz-muenchen.de

Affiliations Computational Modeling in Biology, Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Munich-Neuherberg, Germany, Zentrum Mathematik, Technische Universität München, Garching, Germany, Max-Planck-Institute for Dynamics and Self-Organization, Göttingen, Germany
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Spatial Analysis of Expression Patterns Predicts Genetic Interactions at the Mid-Hindbrain Boundary

Dominik M. Wittmann,
Florian Blöchl,
Dietrich Trümbach,
Wolfgang Wurst,
Nilima Prakash,
Fabian J. Theis

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Published: November 20, 2009
https://doi.org/10.1371/journal.pcbi.1000569

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Gene expression
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Gene regulatory networks
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Hindbrain
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Midbrain
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Simulation and modeling
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Transcription factors
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Gene regulation
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