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Research Article

Identifying Drug Effects via Pathway Alterations using an Integer Linear Programming Optimization Formulation on Phosphoproteomic Data

  • Alexander Mitsos,

    Affiliation: Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Ioannis N. Melas,

    Affiliation: Department of Mechanical Engineering, National Technical University of Athens, Athens, Greece

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  • Paraskeuas Siminelakis,

    Affiliation: Department of Mechanical Engineering, National Technical University of Athens, Athens, Greece

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  • Aikaterini D. Chairakaki,

    Affiliation: Department of Mechanical Engineering, National Technical University of Athens, Athens, Greece

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  • Julio Saez-Rodriguez,

    Affiliations: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Leonidas G. Alexopoulos mail

    leo@mail.ntua.gr

    Affiliation: Department of Mechanical Engineering, National Technical University of Athens, Athens, Greece

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  • Published: December 04, 2009
  • DOI: 10.1371/journal.pcbi.1000591
  • Featured in PLOS Collections

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