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Research Article

Symmetric Allosteric Mechanism of Hexameric Escherichia coli Arginine Repressor Exploits Competition between L-Arginine Ligands and Resident Arginine Residues

  • Rebecca Strawn equal contributor,

    equal contributor Contributed equally to this work with: Rebecca Strawn, Milan Melichercik

    Affiliation: Chemistry Department, Princeton University, Princeton, New Jersey, United States of America

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  • Milan Melichercik equal contributor,

    equal contributor Contributed equally to this work with: Rebecca Strawn, Milan Melichercik

    Affiliation: Department of Structure and Function of Proteins, Institute of Systems Biology and Ecology, Academy of Sciences of the Czech Republic, and Institute of Physical Biology, University of South Bohemia, Nove Hrady, Czech Republic

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  • Michael Green,

    Affiliation: Biology Department, The College of New Jersey, Ewing, New Jersey, United States of America

    Current address: Mount Sinai School of Medicine, New York, New York, United States of America

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  • Thomas Stockner,

    Affiliation: Department of Medical Chemistry, Medical University of Vienna, Vienna, Austria

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  • Jannette Carey mail,

    jcarey@princeton.edu (JC); ettrich@nh.usbe.cas.cz (RE)

    Affiliation: Chemistry Department, Princeton University, Princeton, New Jersey, United States of America

    X
  • Rüdiger Ettrich mail

    jcarey@princeton.edu (JC); ettrich@nh.usbe.cas.cz (RE)

    Affiliation: Department of Structure and Function of Proteins, Institute of Systems Biology and Ecology, Academy of Sciences of the Czech Republic, and Institute of Physical Biology, University of South Bohemia, Nove Hrady, Czech Republic

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  • Published: June 03, 2010
  • DOI: 10.1371/journal.pcbi.1000801

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