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Research Article

Dynamically-Driven Inactivation of the Catalytic Machinery of the SARS 3C-Like Protease by the N214A Mutation on the Extra Domain

  • Jiahai Shi equal contributor,

    equal contributor Contributed equally to this work with: Jiahai Shi, Nanyu Han

    Affiliation: Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

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  • Nanyu Han equal contributor,

    equal contributor Contributed equally to this work with: Jiahai Shi, Nanyu Han

    Affiliation: School of Biological Sciences, Nanyang Technological University, Singapore

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  • Liangzhong Lim,

    Affiliation: Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

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  • Shixiong Lua,

    Affiliation: Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

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  • J. Sivaraman,

    Affiliation: Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

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  • Lushan Wang,

    Affiliation: State Key Laboratory of Microbial Technology, Shandong University, Jinan, China

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  • Yuguang Mu mail,

    bchsj@nus.edu.sg (JS); YGMu@ntu.edu.sg (YM)

    Affiliation: School of Biological Sciences, Nanyang Technological University, Singapore

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  • Jianxing Song mail

    bchsj@nus.edu.sg (JS); YGMu@ntu.edu.sg (YM)

    Affiliations: Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine and National University of Singapore, Singapore

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  • Published: February 24, 2011
  • DOI: 10.1371/journal.pcbi.1001084

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