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Research Article

Interrogation of the Protein-Protein Interactions between Human BRCA2 BRC Repeats and RAD51 Reveals Atomistic Determinants of Affinity

  • Daniel J. Cole,

    Affiliation: Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, Cambridge, United Kingdom

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  • Eeson Rajendra,

    Affiliation: MRC Cancer Cell Unit Hutchison/MRC Research Centre, Cambridge, United Kingdom

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  • Meredith Roberts-Thomson,

    Affiliation: Cambridge Molecular Therapeutics Programme, Hutchison/MRC Research Centre, Cambridge, United Kingdom

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  • Bryn Hardwick,

    Affiliations: MRC Cancer Cell Unit Hutchison/MRC Research Centre, Cambridge, United Kingdom, Cambridge Molecular Therapeutics Programme, Hutchison/MRC Research Centre, Cambridge, United Kingdom

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  • Grahame J. McKenzie,

    Affiliations: MRC Cancer Cell Unit Hutchison/MRC Research Centre, Cambridge, United Kingdom, Cambridge Molecular Therapeutics Programme, Hutchison/MRC Research Centre, Cambridge, United Kingdom

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  • Mike C. Payne,

    Affiliation: Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, Cambridge, United Kingdom

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  • Ashok R. Venkitaraman mail,

    arv@hutchison-mrc.cam.ac.uk(ARV); C.Skylaris@soton.ac.uk(CKS)

    Affiliations: MRC Cancer Cell Unit Hutchison/MRC Research Centre, Cambridge, United Kingdom, Cambridge Molecular Therapeutics Programme, Hutchison/MRC Research Centre, Cambridge, United Kingdom

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  • Chris-Kriton Skylaris mail

    arv@hutchison-mrc.cam.ac.uk(ARV); C.Skylaris@soton.ac.uk(CKS)

    Affiliation: School of Chemistry, University of Southampton, Highfield, Southampton, United Kingdom

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  • Published: July 14, 2011
  • DOI: 10.1371/journal.pcbi.1002096

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