A Mathematical Methodology for Determining the Temporal Order of Pathway Alterations Arising during Gliomagenesis

• Yu-Kang Cheng,

  Affiliations Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America, Cancer Biology and Genetics Program, Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medical College, New York, New York, United States of America

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• Rameen Beroukhim,

  Affiliation Departments of Cancer Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, and Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Ross L. Levine,

  Affiliation Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Ingo K. Mellinghoff,

  Affiliation Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Eric C. Holland,

  Affiliation Cancer Biology and Genetics Program, Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Franziska Michor

  * E-mail: michor@jimmy.harvard.edu

  Affiliation Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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