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Research Article

Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome

  • Sahar Abubucker,

    Affiliation: The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Nicola Segata,

    Affiliation: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Johannes Goll,

    Affiliation: J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Alyxandria M. Schubert,

    Affiliation: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Jacques Izard,

    Affiliations: Department of Molecular Genetics, Forsyth Institute, Cambridge, Massachusetts, United States of America, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America

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  • Brandi L. Cantarel,

    Affiliation: Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Beltran Rodriguez-Mueller,

    Affiliation: Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America

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  • Jeremy Zucker,

    Affiliation: The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Mathangi Thiagarajan,

    Affiliation: J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Bernard Henrissat,

    Affiliation: Architecture et Fonction des Macromolécules Biologiques, UMR 6098 CNRS, Université de la Méditerranée, Marseille, France

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  • Owen White,

    Affiliation: Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Scott T. Kelley,

    Affiliation: Biology Department, San Diego State University, San Diego, California, United States of America

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  • Barbara Methé,

    Affiliation: J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Patrick D. Schloss,

    Affiliation: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Dirk Gevers,

    Affiliation: The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Makedonka Mitreva,

    Affiliation: The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Curtis Huttenhower mail

    chuttenh@hsph.harvard.edu

    Affiliations: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Published: June 13, 2012
  • DOI: 10.1371/journal.pcbi.1002358
  • Featured in PLOS Collections

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