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Research Article

Testing Biochemistry Revisited: How In Vivo Metabolism Can Be Understood from In Vitro Enzyme Kinetics

  • Karen van Eunen,

    Affiliations: Department of Molecular Cell Physiology, VU University Amsterdam, Amsterdam, The Netherlands, Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands, Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • José A. L. Kiewiet,

    Affiliations: Department of Molecular Cell Physiology, VU University Amsterdam, Amsterdam, The Netherlands, Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands

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  • Hans V. Westerhoff,

    Affiliations: Department of Molecular Cell Physiology, VU University Amsterdam, Amsterdam, The Netherlands, Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands, Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary BioCentre, The University of Manchester, Manchester, United Kingdom, Synthetic Systems Biology, Netherlands Institute for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands

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  • Barbara M. Bakker mail

    b.m.bakker@med.umcg.nl

    Affiliations: Department of Molecular Cell Physiology, VU University Amsterdam, Amsterdam, The Netherlands, Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands, Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Published: April 26, 2012
  • DOI: 10.1371/journal.pcbi.1002483

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