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Research Article

Modeling HIV-1 Drug Resistance as Episodic Directional Selection

  • Ben Murrell,

    Affiliations: Biomedical Informatics Research Division, eHealth Research and Innovation Platform, Medical Research Council, Tygerberg, South Africa, Computer Science Division, Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa

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  • Tulio de Oliveira,

    Affiliations: Africa Centre for Health and Population Studies, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa, Research Department of Infection and Population Health, University College London, London, United Kingdom

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  • Chris Seebregts,

    Affiliations: Biomedical Informatics Research Division, eHealth Research and Innovation Platform, Medical Research Council, Tygerberg, South Africa, School of Computer Science, University of KwaZulu-Natal, Durban, South Africa

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  • Sergei L. Kosakovsky Pond,

    Affiliation: Department of Medicine, University of California San Diego, San Diego, California, United States of America

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  • Konrad Scheffler mail,

    kscheffler@ucsd.edu

    Affiliations: Computer Science Division, Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa, Department of Medicine, University of California San Diego, San Diego, California, United States of America

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  • on behalf of the Southern African Treatment and Resistance Network (SATuRN) Consortium
  • Published: May 10, 2012
  • DOI: 10.1371/journal.pcbi.1002507

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