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Research Article

Resolving the Ortholog Conjecture: Orthologs Tend to Be Weakly, but Significantly, More Similar in Function than Paralogs

  • Adrian M. Altenhoff,

    Affiliations: ETH Zurich, Department of Computer Science, Zürich, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Romain A. Studer,

    Affiliations: Swiss Institute of Bioinformatics, Lausanne, Switzerland, Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland, Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom

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  • Marc Robinson-Rechavi,

    Affiliations: Swiss Institute of Bioinformatics, Lausanne, Switzerland, Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland

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  • Christophe Dessimoz mail

    dessimoz@ebi.ac.uk

    Affiliations: ETH Zurich, Department of Computer Science, Zürich, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland, EMBL-European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom

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  • Published: May 17, 2012
  • DOI: 10.1371/journal.pcbi.1002514

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