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Resolving the Ortholog Conjecture: Orthologs Tend to Be Weakly, but Significantly, More Similar in Function than Paralogs

  • Adrian M. Altenhoff,

    Affiliations ETH Zurich, Department of Computer Science, Zürich, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

  • Romain A. Studer,

    Affiliations Swiss Institute of Bioinformatics, Lausanne, Switzerland, Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland, Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom

  • Marc Robinson-Rechavi,

    Affiliations Swiss Institute of Bioinformatics, Lausanne, Switzerland, Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland

  • Christophe Dessimoz

    dessimoz@ebi.ac.uk

    Affiliations ETH Zurich, Department of Computer Science, Zürich, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland, EMBL-European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom

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