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Research Article

Structural and Dynamic Requirements for Optimal Activity of the Essential Bacterial Enzyme Dihydrodipicolinate Synthase

  • C. F. Reboul,

    Affiliations: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia, ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Victoria, Australia

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  • B. T. Porebski,

    Affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

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  • M. D. W. Griffin,

    Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia

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  • R. C. J. Dobson,

    Affiliations: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia, Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia, Biomolecular Interaction Centre, and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand

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  • M. A. Perugini,

    Affiliations: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia, Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia

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  • J. A. Gerrard,

    Affiliation: Biomolecular Interaction Centre, and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand

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  • A. M. Buckle mail

    ashley.buckle@monash.edu

    Affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

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  • Published: June 07, 2012
  • DOI: 10.1371/journal.pcbi.1002537

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