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Research Article

Virtual Patients and Sensitivity Analysis of the Guyton Model of Blood Pressure Regulation: Towards Individualized Models of Whole-Body Physiology

  • Robert Moss,

    Affiliations: IR4M UMR8081 CNRS, Université Paris-Sud, Orsay, France, Institut Gustave Roussy, Villejuif, France, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia

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  • Thibault Grosse,

    Affiliations: IR4M UMR8081 CNRS, Université Paris-Sud, Orsay, France, Institut Gustave Roussy, Villejuif, France

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  • Ivanny Marchant,

    Affiliation: Escuela de Medicina, Departamento de Pre-clínicas, Universidad de Valparaíso, Valparaíso, Chile

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  • Nathalie Lassau,

    Affiliations: IR4M UMR8081 CNRS, Université Paris-Sud, Orsay, France, Institut Gustave Roussy, Villejuif, France

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  • François Gueyffier,

    Affiliations: IMTh – Institute for Theoretical Medicine, Lyon, France, Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France, INSERM, CIC 201, EPICIME, Lyon, France, Service de Pharmacologie Clinique, Hop L Pradel, Centre Hospitalier Universitaire Lyon, Lyon, France

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  • S. Randall Thomas mail

    srandall.thomas@gmail.com

    Affiliations: IR4M UMR8081 CNRS, Université Paris-Sud, Orsay, France, Institut Gustave Roussy, Villejuif, France

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  • Published: June 28, 2012
  • DOI: 10.1371/journal.pcbi.1002571

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