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Research Article

Prediction of Mutational Tolerance in HIV-1 Protease and Reverse Transcriptase Using Flexible Backbone Protein Design

  • Elisabeth Humphris-Narayanan equal contributor,

    equal contributor Contributed equally to this work with: Elisabeth Humphris-Narayanan, Eyal Akiva

    Affiliation: Graduate Group in Biophysics, University of California, San Francisco, San Francisco, California, United States of America

    Current address: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, United States of America

    X
  • Eyal Akiva equal contributor,

    equal contributor Contributed equally to this work with: Elisabeth Humphris-Narayanan, Eyal Akiva

    Affiliations: California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Rocco Varela,

    Affiliation: Graduate Program in Bioinformatics, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Shane Ó Conchúir,

    Affiliations: California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Tanja Kortemme mail

    kortemme@cgl.ucsf.edu

    Affiliations: Graduate Group in Biophysics, University of California, San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America, Graduate Program in Bioinformatics, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Published: August 23, 2012
  • DOI: 10.1371/journal.pcbi.1002639

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