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Research Article

Adding Protein Context to the Human Protein-Protein Interaction Network to Reveal Meaningful Interactions

  • Martin H. Schaefer,

    Affiliation: Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Tiago J. S. Lopes,

    Affiliation: JST ERATO KAWAOKA Infection-induced Host Responses Project, Tokyo, Japan

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  • Nancy Mah,

    Affiliation: Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Jason E. Shoemaker,

    Affiliation: JST ERATO KAWAOKA Infection-induced Host Responses Project, Tokyo, Japan

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  • Yukiko Matsuoka,

    Affiliations: JST ERATO KAWAOKA Infection-induced Host Responses Project, Tokyo, Japan, The Systems Biology Institute, Tokyo, Japan

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  • Jean-Fred Fontaine,

    Affiliation: Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Caroline Louis-Jeune,

    Affiliation: Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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  • Amie J. Eisfeld,

    Affiliation: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Gabriele Neumann,

    Affiliation: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Carol Perez-Iratxeta,

    Affiliation: Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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  • Yoshihiro Kawaoka,

    Affiliations: JST ERATO KAWAOKA Infection-induced Host Responses Project, Tokyo, Japan, Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, Tokyo, Japan

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  • Hiroaki Kitano,

    Affiliations: JST ERATO KAWAOKA Infection-induced Host Responses Project, Tokyo, Japan, Sony Computer Science Laboratories, Inc., Tokyo, Japan, Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa, Japan, Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan

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  • Miguel A. Andrade-Navarro mail

    miguel.andrade@mdc-berlin.de

    Affiliation: Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Published: January 03, 2013
  • DOI: 10.1371/journal.pcbi.1002860

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