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Research Article

Synthetic Lethality between Gene Defects Affecting a Single Non-essential Molecular Pathway with Reversible Steps

  • Andrei Zinovyev equal contributor mail,

    equal contributor Contributed equally to this work with: Andrei Zinovyev, Inna Kuperstein

    Andrei.Zinovyev@curie.fr (AZ); wdheyer@ucdavis.edu (WDH)

    Affiliations: Institut Curie, Paris, France, INSERM, U900, Paris, France, Mines ParisTech, Fontainebleau, France

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  • Inna Kuperstein equal contributor,

    equal contributor Contributed equally to this work with: Andrei Zinovyev, Inna Kuperstein

    Affiliations: Institut Curie, Paris, France, INSERM, U900, Paris, France, Mines ParisTech, Fontainebleau, France

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  • Emmanuel Barillot,

    Affiliations: Institut Curie, Paris, France, INSERM, U900, Paris, France, Mines ParisTech, Fontainebleau, France

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  • Wolf-Dietrich Heyer mail

    Andrei.Zinovyev@curie.fr (AZ); wdheyer@ucdavis.edu (WDH)

    Affiliation: Departments of Microbiology & Molecular Genetics and of Molecular & Cellular Biology, University of California, Davis, Davis, California, United States of America

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  • Published: April 04, 2013
  • DOI: 10.1371/journal.pcbi.1003016

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