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Biochemical Competition Makes Fatty-Acid β-Oxidation Vulnerable to Substrate Overload

  • Karen van Eunen,

    Affiliations Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands

  • Sereh M. J. Simons,

    Affiliation Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

  • Albert Gerding,

    Affiliations Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Department of Laboratory Medicine, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

  • Aycha Bleeker,

    Affiliation Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

  • Gijs den Besten,

    Affiliations Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands

  • Catharina M. L. Touw,

    Affiliation Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

  • Sander M. Houten,

    Affiliation Laboratory Genetic Metabolic Diseases, Departments of Clinical Chemistry and Pediatrics, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  • Bert K. Groen,

    Affiliations Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands

  • Klaas Krab,

    Affiliation Department of Molecular Cell Physiology, Netherlands Institute for Systems Biology, VU University Amsterdam, Amsterdam, The Netherlands

  • Dirk-Jan Reijngoud,

    Affiliations Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands, Department of Laboratory Medicine, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

  • Barbara M. Bakker

    b.m.bakker01@umcg.nl

    Affiliations Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands

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